scholarly journals Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine

Diabetes ◽  
2010 ◽  
Vol 59 (8) ◽  
pp. 1879-1889 ◽  
Author(s):  
Huiling Wang ◽  
Dajun Liu ◽  
Peirang Cao ◽  
Stewart Lecker ◽  
Zhaoyong Hu
Keyword(s):  
Protein Synthesis ◽  
Energy Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

scholarly journals Comparison of protein synthesis and degradation in incubated and perfused muscle

1983 ◽  
Vol 212 (3) ◽  
pp. 649-653 ◽  
Author(s):  
A S Clark ◽  
W E Mitch
Keyword(s):  
Protein Synthesis ◽  
Protein Degradation ◽  
Insulin Treatment ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Muscle Protein Degradation ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

Rates of muscle protein synthesis and degradation measured in the perfused hindquarter were compared with those in incubated epitrochlearis muscles. With fed or starved mature rats, results without insulin treatment were identical. With insulin treatment, protein synthesis in perfused hindquarters was greater, though protein degradation was the same. Thus rates of muscle protein degradation estimated by these two methods in vitro correspond closely.

scholarly journals Skeletal muscle protein synthesis and degradation in patients with chronic renal failure

1994 ◽  
Vol 45 (5) ◽  
pp. 1432-1439 ◽  
Author(s):  
Giacomo Garibotto ◽  
Rodolfo Russo ◽  
Antonella Sofia ◽  
Maria Rita Sala ◽  
Cristina Robaudo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Protein Synthesis ◽  
Chronic Renal Failure ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Skeletal Muscle Protein ◽  
Skeletal Muscle Protein Synthesis ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

scholarly journals Circadian regulation of muscle growth independent of locomotor activity

2019 ◽  
Author(s):  
Jeffrey J. Kelu ◽  
Tapan G. Pipalia ◽  
Simon M. Hughes
Keyword(s):  
Protein Synthesis ◽  
Muscle Protein ◽  
Contractile Activity ◽  
Muscle Protein Synthesis ◽  
Muscle Growth ◽  
Circadian Variation ◽  
Similar Extent ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation ◽  
Proteasomal Inhibitor

AbstractMuscle tissue shows circadian variation, but whether and how the intracellular circadian clock per se regulates muscle growth remains unclear. By measuring muscle growth over 12 h periods, here we show that muscle grows more during the day than at night. Inhibition of muscle contraction reduces growth to a similar extent in day and night, but does not ablate the circadian variation in growth. Muscle protein synthesis is higher during the day compared to night, whereas markers of protein degradation are higher at night. Mechanistically, the TORC1 inhibitor rapamycin inhibits the extra daytime growth, but no effect on muscle growth at night was detected. Conversely, the proteasomal inhibitor MG132 increases muscle growth at night, but has no effect during the day, irrespective of activity. Ablation of contractile activity rapidly reduces muscle protein synthesis both during the day and at night and leads to a gradual increase in Murf gene expression without ablating circadian variation in growth. Removal of circadian input by exposure to either permanent light or permanent darkness reduces muscle growth. We conclude that circadian variation in muscle growth is independent of the presence of, or changes in, physical activity and affects both protein synthesis and degradation in distinct circadian phases.

scholarly journals The influence of dietary leucine above recommendations and fixed ratios to isoleucine and valine on muscle protein synthesis and degradation pathways in broilers

2019 ◽  
Vol 98 (12) ◽  
pp. 6772-6786 ◽  
Author(s):  
Johanna O. Zeitz ◽  
Stella-Christin Käding ◽  
Ines R. Niewalda ◽  
Erika Most ◽  
Juliano C. de Paula Dorigam ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Degradation Pathways ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation
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