scholarly journals Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

Diabetes ◽  
2011 ◽  
Vol 60 (4) ◽  
pp. 1304-1313 ◽  
Author(s):  
Q. Zhong ◽  
R. A. Kowluru
Keyword(s):  
Superoxide Dismutase ◽  
Diabetic Retinopathy ◽  
Epigenetic Changes ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

2020 ◽  
Vol 13 (1) ◽  
pp. 76-83
Author(s):  
Aline Maria Brito Lucas ◽  
Joana Varlla de Lacerda Alexandre ◽  
Maria Thalyne Silva Araújo ◽  
Cicera Edna Barbosa David ◽  
Yuana Ivia Ponte Viana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Cardiac Hypertrophy ◽  
Superoxide Dismutase Activity ◽  
Heart Weight ◽  
Pharmacological Intervention ◽  
Wall Thickening ◽  
H2o2 Production ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

Background: Cardiac hypertrophy involves marked wall thickening or chamber enlargement. If sustained, this condition will lead to dysfunctional mitochondria and oxidative stress. Mitochondria have ATP-sensitive K+ channels (mitoKATP) in the inner membrane that modulate the redox status of the cell. Objective: We investigated the in vivo effects of mitoKATP opening on oxidative stress in isoproterenol- induced cardiac hypertrophy. Methods: Cardiac hypertrophy was induced in Swiss mice treated intraperitoneally with isoproterenol (ISO - 30 mg/kg/day) for 8 days. From day 4, diazoxide (DZX - 5 mg/kg/day) was used in order to open mitoKATP (a clinically relevant therapy scheme) and 5-hydroxydecanoate (5HD - 5 mg/kg/day) or glibenclamide (GLI - 3 mg/kg/day) were used as mitoKATP blockers. Results: Isoproterenol-treated mice had elevated heart weight/tibia length ratios (HW/TL). Additionally, hypertrophic hearts had elevated levels of carbonylated proteins and Thiobarbituric Acid Reactive Substances (TBARS), markers of protein and lipid oxidation. In contrast, mitoKATP opening with DZX avoided ISO effects on gross hypertrophic markers (HW/TL), carbonylated proteins and TBARS, in a manner reversed by 5HD and GLI. Moreover, DZX improved mitochondrial superoxide dismutase activity. This effect was also blocked by 5HD and GLI. Additionally, ex vivo treatment of isoproterenol- induced hypertrophic cardiac tissue with DZX decreased H2O2 production in a manner sensitive to 5HD, indicating that this drug also acutely avoids oxidative stress. Conclusion: Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy. This pharmacological intervention could be a potential therapeutic strategy to prevent oxidative stress associated with cardiac hypertrophy.

Immunoreactivity and activity of mitochondrial superoxide dismutase following training and exercise

1994 ◽  
Vol 1 (3) ◽  
pp. 165-168 ◽  
Author(s):  
Chandan K. Sen ◽  
Tomomi Ookawara ◽  
Keiichiro Suzuki ◽  
Naoyuki Taniguchi ◽  
Osmo Hänninen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

scholarly journals Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions

2016 ◽  
Vol 4 ◽  
pp. 239-246 ◽  
Author(s):  
Adam Piecuch ◽  
Marlena Brzozowa-Zasada ◽  
Bartosz Dziewit ◽  
Oliwia Segiet ◽  
Józef Kurek ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mitochondrial Superoxide ◽  
Immunohistochemical Assessment ◽  
Malignant Lesions ◽  
Mitochondrial Superoxide Dismutase
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