scholarly journals Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes-Mediated Mammary Tumor Progression

Diabetes ◽  
2009 ◽  
Vol 59 (3) ◽  
pp. 686-693 ◽  
Author(s):  
Y. Fierz ◽  
R. Novosyadlyy ◽  
A. Vijayakumar ◽  
S. Yakar ◽  
D. LeRoith
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Progression ◽  
Mammary Tumor ◽  
Mammary Tumor Progression

P35 Reduced serum IGF-1 levels do not affect insulin-mediated mammary tumor progression in type 2 diabetes

2010 ◽  
Vol 20 ◽  
pp. S52
Author(s):  
Y.C. Fierz ◽  
R. Novosyadlyy ◽  
A. Vijayakumar ◽  
S. Yakar ◽  
D. LeRoith
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Progression ◽  
Mammary Tumor ◽  
Mammary Tumor Progression

scholarly journals Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

2010 ◽  
Vol 17 (4) ◽  
pp. 941-951 ◽  
Author(s):  
Yvonne Fierz ◽  
Ruslan Novosyadlyy ◽  
Archana Vijayakumar ◽  
Shoshana Yakar ◽  
Derek LeRoith
Keyword(s):  
Breast Cancer ◽  
Type 2 Diabetes ◽  
Tumor Growth ◽  
Tumor Progression ◽  
Mammary Tumor ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Mtor Inhibition ◽  
Mammary Tumor Progression

Type 2 diabetes increases breast cancer risk and mortality, and hyperinsulinemia is a major mediator of this effect. The mammalian target of rapamycin (mTOR) is activated by insulin and is a key regulator of mammary tumor progression. Pharmacological mTOR inhibition suppresses tumor growth in numerous mammary tumor models in the non-diabetic setting. However, the role of the mTOR pathway in type 2 diabetes-induced tumor growth remains elusive. Herein, we investigated whether the mTOR pathway is implicated in insulin-induced mammary tumor progression in a transgenic mouse model of type 2 diabetes (MKR mice) and evaluated the impact of mTOR inhibition on the diabetic state. Mammary tumor progression was studied in the double transgenic MMTV-Polyoma Virus middle T antigen (PyVmT)/MKR mice and by orthotopic inoculation of PyVmT- and Neu/ErbB2-driven mammary tumor cells (Met-1 and MCNeuA cells respectively). mTOR inhibition by rapamycin markedly suppressed tumor growth in both wild-type and MKR mice. In diabetic animals, however, the promoting action of insulin on tumor growth was completely blunted by rapamycin, despite a worsening of the carbohydrate and lipid metabolism. Taken together, pharmacological mTOR blockade is sufficient to abrogate mammary tumor progression in the setting of hyperinsulinemia, and thus mTOR inhibitors may be an attractive therapeutic modality for breast cancer patients with type 2 diabetes. Careful monitoring of the metabolic state, however, is important as dose adaptations of glucose- and/or lipid-lowering therapy might be necessary.

scholarly journals Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

2009 ◽  
Vol 69 (12) ◽  
pp. 5030-5038 ◽  
Author(s):  
Georgia Agiostratidou ◽  
Maomi Li ◽  
Kimita Suyama ◽  
Ines Badano ◽  
Rinat Keren ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Mammary Tumor ◽  
Mammary Tumor Progression

scholarly journals Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

Oncogene ◽  
2016 ◽  
Vol 36 (10) ◽  
pp. 1394-1403 ◽  
Author(s):  
Z Zelenko ◽  
E J Gallagher ◽  
A Tobin-Hess ◽  
V Belardi ◽  
R Rostoker ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Progression ◽  
Mammary Tumor ◽  
Pulmonary Metastases ◽  
Diabetic Mouse ◽  
Vimentin Expression ◽  
Mammary Tumor Progression

Abstract 1352: Macrophage specific regulation reveals both pro- and anti-tumor effects of NF-kappaB during mammary tumor progression

2010 ◽  
Author(s):  
Linda Connelly ◽  
Whitney Barham ◽  
Hala M. Onishko ◽  
T Zabuawala ◽  
Michael C. Ostrowski ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Mammary Tumor ◽  
Specific Regulation ◽  
Nf Kappab ◽  
Mammary Tumor Progression

Abstract 5095: Hic-5 modulation of the stromal matrix is required for mammary tumor progression

2016 ◽  
Author(s):  
Gregory J. Goreczny ◽  
Jessica Ouderkirk ◽  
Eric Olson ◽  
Mira Krendel ◽  
Christopher Turner
Keyword(s):  
Tumor Progression ◽  
Mammary Tumor ◽  
Stromal Matrix ◽  
Mammary Tumor Progression
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