scholarly journals TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

Diabetes ◽  
2009 ◽  
Vol 59 (2) ◽  
pp. 479-485 ◽  
Author(s):  
D. T. Villareal ◽  
H. Robertson ◽  
G. I. Bell ◽  
B. W. Patterson ◽  
H. Tran ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tcf7l2 Variant

The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 340-OR
Author(s):  
ALFONSO GALDERISI ◽  
BRIDGET PIERPONT ◽  
DAVID D'ALESSIO ◽  
NICOLA SANTORO ◽  
SONIA CAPRIO
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Incretin Effect ◽  
Onset Type ◽  
Tcf7l2 Variant

1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1721-P
Author(s):  
DAVID S. MATHIESEN ◽  
ASGER B. LUND ◽  
KATRINE BAGGE HANSEN ◽  
ANDERS JUNKER ◽  
THOMAS IDORN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Incretin Effect ◽  
Normal Glucose ◽  
Tcf7l2 Variant

scholarly journals The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Shuxia Wang ◽  
Kangxing Song ◽  
Roshni Srivastava ◽  
Mohsen Fathzadeh ◽  
Na Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Plasma Lipids ◽  
Meta Analysis ◽  
Plasma Lipid ◽  
Recessive Model ◽  
Plasma Triglyceride ◽  
Recessive Homozygote ◽  
Tcf7l2 Variant

Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.Results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00),P= 0.048,Pheterogeneity= 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02),P= 0.01,Pheterogeneity= 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.Conclusions. Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

scholarly journals Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

Diabetologia ◽  
2013 ◽  
Vol 56 (11) ◽  
pp. 2414-2423 ◽  
Author(s):  
Fabrice Bonnet ◽  
◽  
Ronan Roussel ◽  
Andrea Natali ◽  
Stéphane Cauchi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Parental History ◽  
Incident Hypertension ◽  
History Of ◽  
Tcf7l2 Variant
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