scholarly journals Lipoprotein Particle Size and Concentration by Nuclear Magnetic Resonance and Incident Type 2 Diabetes in Women

Diabetes ◽  
2010 ◽  
Vol 59 (5) ◽  
pp. 1153-1160 ◽  
Author(s):  
S. Mora ◽  
J. D. Otvos ◽  
R. S. Rosenson ◽  
A. Pradhan ◽  
J. E. Buring ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nuclear Magnetic Resonance ◽  
Particle Size ◽  
Magnetic Resonance ◽  
Incident Type ◽  
Lipoprotein Particle ◽  
Incident Type 2 Diabetes ◽  
Lipoprotein Particle Size ◽  
Nuclear Magnetic

Effect of improving glycemic control on low-density lipoprotein particle size in type 2 diabetes

Metabolism ◽  
2003 ◽  
Vol 52 (12) ◽  
pp. 1576-1578 ◽  
Author(s):  
Ana Marı́a Wägner ◽  
Oscar Jorba ◽  
Mercedes Rigla ◽  
Rosa Bonet ◽  
Alberto de Leiva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Particle Size ◽  
Glycemic Control ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Particle ◽  
Lipoprotein Particle Size

scholarly journals Lower Plasma Magnesium, Measured by Nuclear Magnetic Resonance Spectroscopy, is Associated with Increased Risk of Developing Type 2 Diabetes Mellitus in Women: Results from a Dutch Prospective Cohort Study

2019 ◽  
Vol 8 (2) ◽  
pp. 169 ◽  
Author(s):  
Joëlle C. Schutten ◽  
António W. Gomes-Neto ◽  
Gerjan Navis ◽  
Ron T. Gansevoort ◽  
Robin P.F. Dullaart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Nuclear Magnetic Resonance ◽  
Type 2 Diabetes Mellitus ◽  
Magnetic Resonance ◽  
Inverse Association ◽  
Increased Risk ◽  
Study Results ◽  
Nuclear Magnetic

Background: Low circulating magnesium (Mg) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM). We aimed to study the performance of a nuclear magnetic resonance (NMR)-based assay that quantifies ionized Mg in EDTA plasma samples and prospectively investigate the association of Mg with the risk of T2DM. Methods: The analytic performance of an NMR-based assay for measuring plasma Mg was evaluated. We studied 5747 subjects free of T2DM at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) study. Results: Passing–Bablok regression analysis, comparing NMR-measured ionized Mg with total Mg measured by the Roche colorimetric assay, produced a correlation of r = 0.90, with a slope of 1.08 (95% CI: 1.00–1.13) and an intercept of 0.02 (95% CI: −0.02–0.08). During a median follow-up period of 11.2 (IQR: 7.7–12.0) years, 289 (5.0%) participants developed T2DM. The association of NMR-measured ionized Mg with T2DM risk was modified by sex (Pinteraction = 0.007). In women, we found an inverse association between Mg and the risk of developing T2DM, independent of adjustment for potential confounders (HR: 1.80; 95% CI: 1.20–2.70). In men, we found no association between Mg and the risk of developing T2DM (HR: 0.90; 95%: 0.67–1.21). Conclusion: Lower NMR-measured plasma ionized Mg was independently associated with a higher risk of developing T2DM in women, but not in men.

The effect of acute endurance exercise on lipoproteins: a comparison of the nuclear magnetic resonance technique with the conventional lipid profile in healthy men

2014 ◽  
Vol 39 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Hanaa Adnan Shaheen ◽  
Patricia T. Alpert ◽  
James Navalta ◽  
Richard D. Tandy ◽  
Jack C. Young ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Nuclear Magnetic Resonance ◽  
Particle Size ◽  
Magnetic Resonance ◽  
Lipid Profile ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Healthy Men ◽  
Lipoprotein Particle ◽  
Lipoprotein Particle Size

Nuclear magnetic resonance (NMR) of lipoprotein particle size and number may provide greater sensitivity to detecting cardiovascular disease risk compared with the conventional lipid profile in some individuals. The salubrious effect of cardiovascular exercise on blood lipids using the conventional profile is well documented; however, NMR analysis is lacking. The purpose of this study was to examine the effect of a 60-min bout of dynamic exercise on lipoprotein particle size and number as measured by NMR and compare it with the conventional blood lipid profile. Eight active, healthy men (26 ± 5.17 years) ran for 60 min at 70% maximal oxygen uptake on a motor-driven treadmill. Fasting blood samples were drawn at pre-exercise and 5–10 min and 24 h postexercise. The conventional lipid profile showed a significant change in triglycerides (p = 0.019) immediately after exercise with an increase of 22% and a nonsignificant decrease of 13% from baseline after 24 h. The NMR profile showed a significant change in the large high-density lipoprotein particle concentration (p = 0.046) with an increase of 5.8% immediately after exercise, and a decrease of 6.7% at 24 h after exercise. None of the NMR profile changes were significantly different from the baseline value. These data suggest that sensitivity differences between techniques depend on the variable considered; however, they do not warrant concomitant analysis in future studies using this population. Finally, no appreciable favorable or adverse effect was observed in the overall cardiovascular disease risk profile in active, normolipidemic males.

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