scholarly journals Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk

Diabetes ◽  
2009 ◽  
Vol 59 (3) ◽  
pp. 741-746 ◽  
Author(s):  
K. A. Fawcett ◽  
E. Wheeler ◽  
A. P. Morris ◽  
S. L. Ricketts ◽  
G. Hallmans ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Frequency ◽  
Diabetes Risk

scholarly journals A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 841 ◽  
Author(s):  
Britt Burton-Freeman ◽  
Michał Brzeziński ◽  
Eunyoung Park ◽  
Amandeep Sandhu ◽  
Di Xiao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Reduction ◽  
Critical Role ◽  
Glucose Absorption ◽  
Diabetes Risk ◽  
Fiber Plant

Type 2 diabetes mellitus (T2DM) is the most common form of DM and its prevalence is increasing worldwide. Because it is a progressive disease, prevention, early detection and disease course modification are possible. Diet plays a critical role in reducing T2DM risk. Therapeutic dietary approaches routinely recommend diets high in plant foods (i.e., vegetables, fruits, whole-grains). In addition to essential micronutrients and fiber, plant-based diets contain a wide-variety of polyphenols, specifically flavonoid compounds. Evidence suggests that flavonoids may confer specific benefits for T2DM risk reduction through pathways influencing glucose absorption and insulin sensitivity and/or secretion. The present review assesses the relationship between dietary flavonoids and diabetes risk reduction reviewing current epidemiology and clinical research. Collectively, the research indicates that certain flavonoids, explicitly anthocyanins and flavan-3-ols and foods rich in these compounds, may have an important role in dietary algorithms aimed to address diabetes risk factors and the development of T2DM.

scholarly journals Diabetes inHFEHemochromatosis

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
James C. Barton ◽  
Ronald T. Acton
Keyword(s):  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Iron Homeostasis ◽  
Reference Range ◽  
Clinical Manifestations ◽  
Diabetes Type 2 ◽  
Diabetes Risk ◽  
European Descent

Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes inHFEhemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk inHFEhemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons withHFEhemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and withoutHFEhemochromatosis is similar. Routine iron phenotyping orHFEgenotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes inHFEhemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and withoutHFEhemochromatosis.

scholarly journals Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

Diabetes ◽  
2011 ◽  
Vol 61 (2) ◽  
pp. 524-530 ◽  
Author(s):  
M. Marquez ◽  
M. Huyvaert ◽  
J. R. B. Perry ◽  
R. D. Pearson ◽  
M. Falchi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Frequency ◽  
Diabetes Risk

scholarly journals Comment on: Marquez et al. Low-Frequency Variants inHMGA1Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530

Diabetes ◽  
2012 ◽  
Vol 61 (5) ◽  
pp. e3-e3 ◽  
Author(s):  
Antonio Brunetti ◽  
Eusebio Chiefari ◽  
Clive R. Pullinger ◽  
Sinan Tanyolac ◽  
Daniela Foti ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Frequency ◽  
Diabetes Risk

scholarly journals Dietary inflammatory index and type 2 diabetes risk in a prospective cohort of 70,991 women followed for 20 years: the mediating role of BMI

Diabetologia ◽  
2019 ◽  
Vol 62 (12) ◽  
pp. 2222-2232 ◽  
Author(s):  
Nasser Laouali ◽  
Francesca Romana Mancini ◽  
Mariem Hajji-Louati ◽  
Douae El Fatouhi ◽  
Beverley Balkau ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Cohort ◽  
Diabetes Risk ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Mediating Role

Patients’ intentions to inform relatives about Type 2 diabetes risk: the role of worry in the process of family risk disclosure

2012 ◽  
Vol 29 (12) ◽  
pp. e461-e467 ◽  
Author(s):  
S. C. M. van Esch ◽  
M. D. Nijkamp ◽  
M. C. Cornel ◽  
F. J. Snoek
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Risk Disclosure ◽  
Family Risk

Obesity and Type 2 Diabetes Risk in Midadult Life: The Role of Childhood Adversity

PEDIATRICS ◽  
2008 ◽  
Vol 121 (5) ◽  
pp. e1240-e1249 ◽  
Author(s):  
C. Thomas ◽  
E. Hypponen ◽  
C. Power
Keyword(s):  
Type 2 Diabetes ◽  
Childhood Adversity ◽  
Diabetes Risk
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