scholarly journals Haptoglobin Genotype and Renal Function Decline in Type 1 Diabetes

Diabetes ◽  
2009 ◽  
Vol 58 (12) ◽  
pp. 2904-2909 ◽  
Author(s):  
Tina Costacou ◽  
Robert E. Ferrell ◽  
Demetrius Ellis ◽  
Trevor J. Orchard
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Renal Function Decline ◽  
Haptoglobin Genotype

scholarly journals Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Maria Beatriz Monteiro ◽  
Tatiana S. Pelaes ◽  
Daniele P. Santos-Bezerra ◽  
Karina Thieme ◽  
Antonio M. Lerario ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Longitudinal Data ◽  
Urinary Sediment ◽  
Renal Function Decline

scholarly journals Urinary Peptidome May Predict Renal Function Decline in Type 1 Diabetes and Microalbuminuria

2009 ◽  
Vol 20 (9) ◽  
pp. 2065-2074 ◽  
Author(s):  
Michael L. Merchant ◽  
Bruce A. Perkins ◽  
Grzegorz M. Boratyn ◽  
Linda H. Ficociello ◽  
Daniel W. Wilkey ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Renal Function Decline

scholarly journals Quantitative levels of serum N-glycans in type 1 diabetes and their association with kidney disease

Glycobiology ◽  
2020 ◽  
Author(s):  
Marco Colombo ◽  
Akram Asadi Shehni ◽  
Ioanna Thoma ◽  
Stuart J McGurnaghan ◽  
Luke A K Blackbourn ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Kidney Disease ◽  
Research Network ◽  
Diabetes Research ◽  
Serum Samples ◽  
Cross Sectional ◽  
Total N ◽  
Renal Function Decline

Abstract We investigated associations of quantitative levels of N-glycans with hemoglobin A1c (HbA1c), renal function and renal function decline in type 1 diabetes. We measured 46 total N-glycan peaks (GPs) on 1565 serum samples from the Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO) and a pool of healthy donors. Quantitation of absolute abundance of each GP used 2AB-labeled mannose-3 as a standard. We studied cross-sectional associations of GPs and derived measures with HbA1c, albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR), and prospective associations with incident albuminuria and final eGFR. All GPs were 1.4 to 3.2 times more abundant in SDRTN1BIO than in the healthy samples. Absolute levels of all GPs were slightly higher with higher HbA1c, with strongest associations for triantennary trigalactosylated disialylated, triantennary trigalactosylated trisialylated structures with core or outer arm fucose, and tetraantennary tetragalactosylated trisialylated glycans. Most GPs showed increased abundance with worsening ACR. Lower eGFR was associated with higher absolute GP levels, most significantly with biantennary digalactosylated disialylated glycans with and without bisect, triantennary trigalactosylated trisialylated glycans with and without outer arm fucose, and core fucosylated biantennary monogalactosylated monosialylated glycans. Although several GPs were inversely associated prospectively with final eGFR, cross-validated multivariable models did not improve prediction beyond clinical covariates. Elevated HbA1c is associated with an altered N-glycan profile in type 1 diabetes. Although we could not establish GPs to be prognostic of future renal function decline independently of HbA1c, further studies to evaluate their impact in the pathogenesis of diabetic kidney disease are warranted.

scholarly journals Novel Urinary Protein Biomarkers Predicting the Development of Microalbuminuria and Renal Function Decline in Type 1 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (3) ◽  
pp. 549-555 ◽  
Author(s):  
D. Schlatzer ◽  
D. M. Maahs ◽  
M. R. Chance ◽  
J.-E. Dazard ◽  
X. Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Urinary Protein ◽  
Protein Biomarkers ◽  
Renal Function Decline

scholarly journals Microalbuminuria and the Risk for Early Progressive Renal Function Decline in Type 1 Diabetes

2007 ◽  
Vol 18 (4) ◽  
pp. 1353-1361 ◽  
Author(s):  
Bruce A. Perkins ◽  
Linda H. Ficociello ◽  
Betsy E. Ostrander ◽  
Kristen H. Silva ◽  
Janice Weinberg ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Renal Function Decline
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