scholarly journals Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes

Diabetes ◽  
2010 ◽  
Vol 59 (6) ◽  
pp. 1292-1301 ◽  
Author(s):  
S. Mas ◽  
R. Martinez-Pinna ◽  
J. L. Martin-Ventura ◽  
R. Perez ◽  
D. Gomez-Garre ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Esterified Fatty Acids

scholarly journals The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes

2021 ◽  
Vol 22 (18) ◽  
pp. 10140
Author(s):  
Stephen J. Hierons ◽  
Jordan S. Marsh ◽  
Dongmei Wu ◽  
Claudia A. Blindauer ◽  
Alan J. Stewart
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Plasma Zinc ◽  
Disease Mechanism ◽  
Plasma Nefa ◽  
Thrombotic Risk ◽  
Esterified Fatty Acids ◽  
Coagulation Proteins ◽  
Thrombotic Complications

Thrombosis is a major comorbidity of obesity and type-2 diabetes mellitus (T2DM). Despite the development of numerous effective treatments and preventative strategies to address thrombotic disease in such individuals, the incidence of thrombotic complications remains high. This suggests that not all the pathophysiological mechanisms underlying these events have been identified or targeted. Non-esterified fatty acids (NEFAs) are increasingly regarded as a nexus between obesity, insulin resistance, and vascular disease. Notably, plasma NEFA levels are consistently elevated in obesity and T2DM and may impact hemostasis in several ways. A potentially unrecognized route of NEFA-mediated thrombotic activity is their ability to disturb Zn2+ speciation in the plasma. Zn2+ is a potent regulator of coagulation and its availability in the plasma is monitored carefully through buffering by human serum albumin (HSA). The binding of long-chain NEFAs such as palmitate and stearate, however, trigger a conformational change in HSA that reduces its ability to bind Zn2+, thus increasing the ion’s availability to bind and activate coagulation proteins. NEFA-mediated perturbation of HSA-Zn2+ binding is thus predicted to contribute to the prothrombotic milieu in obesity and T2DM, representing a novel targetable disease mechanism in these disorders.

scholarly journals Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48852 ◽  
Author(s):  
Dmitry Grapov ◽  
Sean H. Adams ◽  
Theresa L. Pedersen ◽  
W. Timothy Garvey ◽  
John W. Newman
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Esterified Fatty Acids

Non-esterified fatty acids are related with hypofibrinolysis in type 2 diabetes mellitus

1994 ◽  
Vol 8 ◽  
pp. 25-27 ◽  
Author(s):  
H.E. Brussaard ◽  
J.A. Gevers Leuven ◽  
H.M.J. Krans ◽  
P. Meijer ◽  
R. Buytenhek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Esterified Fatty Acids

Regulation of Non-esterified Fatty Acids Flux by Sodium 4-Phenybutyrate in a Nutritional Model of Type 2 Diabetes

2012 ◽  
Vol 36 (5) ◽  
pp. S9-S10
Author(s):  
Thomas Grenier-Larouche ◽  
Sebastien M. Labbe ◽  
Christophe Noll ◽  
Andre Carpentier
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Esterified Fatty Acids

scholarly journals Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

2019 ◽  
Author(s):  
Amélie I. S. Sobczak ◽  
Kondwani G. H. Katundu ◽  
Fladia A. Phoenix ◽  
Siavash Khazaipoul ◽  
Ruitao Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Platelet Rich Plasma ◽  
Fibrin Clot ◽  
Plasma Zinc ◽  
Thrombotic Risk ◽  
Esterified Fatty Acids ◽  
Increased Risk ◽  
Zinc Speciation

AbstractZn2+ is an essential regulator of coagulation and its availability in plasma is fine-tuned through buffering by human serum albumin (HSA). Non-esterified fatty acids (NEFAs) transported by HSA reduce its ability to bind/buffer Zn2+. This is important as plasma NEFA levels are elevated in type-2 diabetes mellitus (T2DM) and other diseases with an increased risk of developing thrombotic complications. The presence of 5 mol. eq. of myristate, palmitate, stearate, palmitoleate and palmitelaidate reduced Zn2+ binding to HSA. Addition of myristate and Zn2+ increased thrombin-induced platelet aggregation in platelet-rich plasma and increased fibrin clot density and clot time in a purified protein system. The concentrations of key saturated (myristate, palmitate, stearate) and monounsaturated (oleate, vaccinate) NEFAs positively correlated with clot density in subjects with T2DM (and controls). Collectively, these data strongly support the concept that elevated NEFA levels contribute to an increased thrombotic risk in T2DM through dysregulation of plasma zinc speciation.

The Role of Plasma Non-esterified Fatty Acids During Exercise in Type 2 Diabetes Mellitus

1993 ◽  
Vol 10 (2) ◽  
pp. 152-158 ◽  
Author(s):  
T.S. Berrish ◽  
C. Elliott ◽  
B.G. Cooper ◽  
J.W. Reed ◽  
H. Orskov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Esterified Fatty Acids

Acute Changes in Non-esterified Fatty Acids in Patients with Type 2 Diabetes Receiving Bariatric Surgery

2016 ◽  
Vol 27 (3) ◽  
pp. 649-656 ◽  
Author(s):  
Reza Nemati ◽  
Jun Lu ◽  
Andrea Tura ◽  
Greg Smith ◽  
Rinki Murphy
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Fatty Acids ◽  
Esterified Fatty Acids ◽  
Acute Changes
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