scholarly journals Challenges in Understanding Diabetic Embryopathy

Diabetes ◽  
2008 ◽  
Vol 57 (12) ◽  
pp. 3187-3188 ◽  
Author(s):  
Mary R. Loeken
Keyword(s):  
Diabetic Embryopathy

Verbascoside‐enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model

2021 ◽  
Author(s):  
Gladys Chirino‐Galindo ◽  
Ilse‐Valeria López‐Quintero ◽  
Liliana‐Berenice Ramírez‐Domínguez ◽  
Leonardo‐Elías Cabrera‐Nájera ◽  
Edgar‐Antonio Estrella‐Parra ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Embryopathy ◽  
Buddleja Cordata

scholarly journals Resveratrol Prevents Impairment in Activation of Retinoic Acid Receptors and MAP Kinases in the Embryos of a Rodent Model of Diabetic Embryopathy

2012 ◽  
Vol 19 (9) ◽  
pp. 949-961 ◽  
Author(s):  
Chandra K. Singh ◽  
Ambrish Kumar ◽  
Holly A. LaVoie ◽  
Donald J. DiPette ◽  
Ugra S. Singh
Keyword(s):  
Retinoic Acid ◽  
Map Kinases ◽  
Rodent Model ◽  
Retinoic Acid Receptors ◽  
Diabetic Embryopathy

Abstract 172: The Role of Activin A in Maternal Diabetes-Induced Cardiac Malformations

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Zhiyong Zhao
Keyword(s):  
High Glucose ◽  
Heart Defects ◽  
Maternal Diabetes ◽  
Activin A ◽  
Brdu Incorporation ◽  
Control Group ◽  
Endocardial Cushions ◽  
Diabetic Embryopathy ◽  
Cardiac Malformations

Diabetes mellitus in pregnancy causes heart defects, especially atrioventricular septal defects (AVSDs), in infants. Manifestation of AVSDs results from dysmorphogenesis of the endocardial cushions in the embryo, which is regulated by members of the transforming growth factor (TGF) β family. Among the TGFβs, we have previously observed that the inhibin βA gene, which encodes a protein to form homodimers as activin A, is markedly downregulated by maternal diabetes. To further determine the involvement of inhibin βA and its signaling in diabetic embryopathy, the levels of inhibin βA protein and activation of its downstream transcription factors, Smad2 and Smad3, were examined using immunohistochemical, proximity ligation, and immunoblot assays, and shown to be decreased in the embryonic hearts of diabetic mice induced via intravenous injection of streptozotocin. To investigate the role of activin A in hyperglycemia-induced cardiac malformations, mouse embryos at embryonic day 9.5 (E9.5) cultured in high glucose (22 mM) were treated with activin A (50 ng/ml) for 24 hours. The treatment rescued the development of the endocardial cushions and cell proliferation (BrdU-incorporation assay) in the myocardium, similar to those in normal glucose control (8.3 mM). The role of activin A in endocardial cell migration, an important process for cellularization of the cardiac jelly, was investigated by treating E10.5 endocardial cushion explants cultured in high glucose with activin A (50 ng/ml) in a collagen matrix-based assay system. The treatment significantly increased the number of migrating cells, compared with that in high glucose-treated group, to the level in the control group. These effects were associated with restoration of the activation of Smad2/3. The results demonstrate that the activin-Smad2/3 signaling system plays an important role in cardiac malformation in diabetic embryopathy.

scholarly journals The increased activity of a transcription factor inhibits autophagy in diabetic embryopathy

2019 ◽  
Vol 220 (1) ◽  
pp. 108.e1-108.e12
Author(s):  
Cheng Xu ◽  
Xi Chen ◽  
E. Albert Reece ◽  
Wenhui Lu ◽  
Peixin Yang
Keyword(s):  
Transcription Factor ◽  
Diabetic Embryopathy ◽  
Increased Activity

scholarly journals Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy

Diabetologia ◽  
2010 ◽  
Vol 53 (9) ◽  
pp. 2046-2055 ◽  
Author(s):  
Y. Kamimoto ◽  
T. Sugiyama ◽  
T. Kihira ◽  
L. Zhang ◽  
N. Murabayashi ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Diabetic Embryopathy ◽  
Apoptotic Protein ◽  
Thioredoxin 1

Postimplantation diabetic embryopathy

2018 ◽  
pp. 329-350 ◽  
Author(s):  
Ulf J. Eriksson ◽  
Parri Wentzel
Keyword(s):  
Diabetic Embryopathy

scholarly journals In vitro study of the carry-over effect associated with early diabetic embryopathy in the rat

Diabetologia ◽  
1994 ◽  
Vol 37 (9) ◽  
pp. 855-862 ◽  
Author(s):  
S. Pampfer ◽  
Y. D. Wuu ◽  
I. Vanderheyden ◽  
R. De Hertogh
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Diabetic Embryopathy ◽  
Carry Over ◽  
Carry Over Effect
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