scholarly journals HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

Diabetes ◽  
2008 ◽  
Vol 57 (4) ◽  
pp. 1084-1092 ◽  
Author(s):  
H. Erlich ◽  
A. M. Valdes ◽  
J. Noble ◽  
J. A. Carlson ◽  
M. Varney ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Analysis ◽  
Diabetes Risk ◽  
Hla Dr ◽  
Diabetes Genetics

scholarly journals Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

2015 ◽  
Vol 47 (8) ◽  
pp. 898-905 ◽  
Author(s):  
Xinli Hu ◽  
Aaron J Deutsch ◽  
Tobias L Lenz ◽  
Suna Onengut-Gumuscu ◽  
Buhm Han ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Amino Acid ◽  
Interaction Effects ◽  
Diabetes Risk ◽  
Hla Dr ◽  
Hla Dq

scholarly journals rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes

2012 ◽  
Vol 13 (8) ◽  
pp. 611-615 ◽  
Author(s):  
Kelly Johnson ◽  
Randall Wong ◽  
Katherine J Barriga ◽  
Georgeanna Klingensmith ◽  
Anette-G Ziegler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
High Risk ◽  
Diabetes Risk ◽  
Hla Dr

scholarly journals Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S.

2021 ◽  
Author(s):  
Vibha Anand ◽  
Ying Li ◽  
Bin Liu ◽  
Mohamed Ghalwash ◽  
Eileen Koski ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Diabetes Risk ◽  
Islet Autoantibodies ◽  
Islet Autoimmunity ◽  
Diabetes Incidence ◽  
Prospective Cohort Studies ◽  
Hla Dr

OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and to estimate risk of islet autoimmunity and progression to clinical diabetes. <p>RESEARCH DESIGN AND METHODS: Prospective cohorts in Finland, Germany, Sweden and the US have followed 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes. Following harmonization, the outcomes were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.</p> <p>RESULTS: In the infant-toddler cohort, 1413 (8.5%) developed at least one autoantibody confirmed at two or more consecutive visits (seroconversion), 865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to diabetes. The 15-year cumulative incidence of diabetes varied in children with one, two or three autoantibodies at seroconversion: 45% (95% CI 40-52%), 85% (78-90%), and 92% (85-97%), respectively. Among those with single autoantibody, their status two years after seroconversion predicted diabetes risk: 12% (10-25%) if reverting to autoantibody negative, 30% (20-40%) if retaining single autoantibody, and 82% (80-95%) if developing multiple autoantibodies. HLA-DR-DQ affected the risk of confirmed seroconversion and progression to diabetes in children with stable single autoantibody. Their 15-year diabetes incidence for higher vs. lower risk genotypes was 40% (28-50%) vs. 12% (5-38%). The rate of progression to diabetes was inversely related to age at development of multiple autoantibodies ranging from 20%/year to 6%/year in children developing multi-positivity ≤2 years or >7.4 years, respectively. </p> <p>CONCLUSIONS: The number of islet autoantibodies at seroconversion reliably predicts 15-year type 1 diabetes risk. In children retaining single autoantibody, HLA-DR-DQ genotypes can further refine risk of progression.</p>

scholarly journals Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates

2005 ◽  
Vol 6 (3) ◽  
pp. 136-144 ◽  
Author(s):  
Lisa M Emery ◽  
Sunanda Babu ◽  
Teodorica L Bugawan ◽  
Jill M Norris ◽  
Henry A Erlich ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Risk Estimates ◽  
Hla Dr ◽  
Genotype Screening

scholarly journals Estimation of Diabetes Risk in Brazilian Population by Typing for Polymorphisms in HLA-DR-DQ, INS and CTLA-4 Genes

2005 ◽  
Vol 21 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Omar M. Hauache ◽  
André F. Reis ◽  
Carolina S.V. Oliveira ◽  
José Gilberto H. Vieira ◽  
Minna Sjüroos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Gene Polymorphisms ◽  
Diabetes Risk ◽  
Brazilian Population ◽  
Healthy Controls ◽  
Typing Method ◽  
Hla Dr ◽  
Screening Sensitivity

The study aimed to further characterise HLA encoded risk factors of type 1 diabetes (T1D) in Brazilian population and test the capability of a low resolution full-house DR-DQ typing method to find subjects at diabetes risk. Insulin and CTLA-4 gene polymorphisms were also analysed. The method is based on an initial DQB1 typing supplemented by DQA1 and DR4 subtyping when informative. Increased frequencies of both (DR3)-DQA1*05-DQB1*02 and DRB1*04-DQA1*03-DQB1*0302 haplotypes were detected among patients. DRB1*0401, *0402, *0404 and *0405 alleles were all common in DQB1*0302 haplotypes and associated with T1D. (DRB1*11/12/1303)-DQA1*05-DQB1*0301, (DRB1*01/10)-DQB1*0501, (DRB1*15)-DQB1*0602 and (DRB1*1301)-*0603 haplotypes were significantly decreased among patients. Genotypes with two risk haplotypes or a combination of a susceptibility associated and a neutral haplotype were found in 78 of 126 (61.9%) T1D patients compared to 8 of 75 (10.7%) control subjects (P< 0.0001). Insulin gene −2221 C/T polymorphism was also associated with diabetes risk: CC genotype was found among 83.1% of patients compared to 69.3% of healthy controls (P= 0.0369, OR 1.98) but CTLA-4 gene +49 A/G polymorphism did not significantly differ between patients and controls. Despite the diversity of the Brazilian population the screening sensitivity and specificity of the used method for T1D risk was similar to that obtained in Europe.

scholarly journals Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S.

2021 ◽  
Author(s):  
Vibha Anand ◽  
Ying Li ◽  
Bin Liu ◽  
Mohamed Ghalwash ◽  
Eileen Koski ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Diabetes Risk ◽  
Islet Autoantibodies ◽  
Islet Autoimmunity ◽  
Diabetes Incidence ◽  
Prospective Cohort Studies ◽  
Hla Dr

OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and to estimate risk of islet autoimmunity and progression to clinical diabetes. <p>RESEARCH DESIGN AND METHODS: Prospective cohorts in Finland, Germany, Sweden and the US have followed 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes. Following harmonization, the outcomes were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.</p> <p>RESULTS: In the infant-toddler cohort, 1413 (8.5%) developed at least one autoantibody confirmed at two or more consecutive visits (seroconversion), 865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to diabetes. The 15-year cumulative incidence of diabetes varied in children with one, two or three autoantibodies at seroconversion: 45% (95% CI 40-52%), 85% (78-90%), and 92% (85-97%), respectively. Among those with single autoantibody, their status two years after seroconversion predicted diabetes risk: 12% (10-25%) if reverting to autoantibody negative, 30% (20-40%) if retaining single autoantibody, and 82% (80-95%) if developing multiple autoantibodies. HLA-DR-DQ affected the risk of confirmed seroconversion and progression to diabetes in children with stable single autoantibody. Their 15-year diabetes incidence for higher vs. lower risk genotypes was 40% (28-50%) vs. 12% (5-38%). The rate of progression to diabetes was inversely related to age at development of multiple autoantibodies ranging from 20%/year to 6%/year in children developing multi-positivity ≤2 years or >7.4 years, respectively. </p> <p>CONCLUSIONS: The number of islet autoantibodies at seroconversion reliably predicts 15-year type 1 diabetes risk. In children retaining single autoantibody, HLA-DR-DQ genotypes can further refine risk of progression.</p>

Immunization profiles and progression of islet autoimmunity in children at type 1 diabetes risk

2012 ◽  
Vol 7 (S 01) ◽  
Author(s):  
R Chmiel ◽  
S Krause ◽  
A Knopff ◽  
C Matzke ◽  
D Höfelmann ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Islet Autoimmunity

scholarly journals HLA-DR-DQ Haplotype in Rapid-Onset Type 1 Diabetes in Japanese

Diabetes Care ◽  
2003 ◽  
Vol 26 (5) ◽  
pp. 1640-1641 ◽  
Author(s):  
T. Nakamura ◽  
S. Nagasaka ◽  
I. Kusaka ◽  
T. Yatagai ◽  
J. Yang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Rapid Onset ◽  
Onset Type ◽  
Hla Dr
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