scholarly journals Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells

Diabetes ◽  
2008 ◽  
Vol 58 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Y. Ikegami ◽  
K. Inukai ◽  
K. Imai ◽  
Y. Sakamoto ◽  
H. Katagiri ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heavy Chain ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Ferritin Heavy Chain

scholarly journals Mutated WWP1 Induces an Aberrant Expression of Myosin Heavy Chain Gene in C2C12 Skeletal Muscle Cells

2010 ◽  
Vol 47 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Hirokazu Matsumoto ◽  
Yumi Inba ◽  
Shinji Sasazaki ◽  
Akira Fujiwara ◽  
Nobutsune Ichihara ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Aberrant Expression ◽  
C2c12 Skeletal Muscle Cells

IL-7 is expressed and secreted by human skeletal muscle cells

2010 ◽  
Vol 298 (4) ◽  
pp. C807-C816 ◽  
Author(s):  
Fred Haugen ◽  
Frode Norheim ◽  
Henrik Lian ◽  
Andreas J. Wensaas ◽  
Svein Dueland ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Real Time ◽  
Satellite Cells ◽  
Heavy Chain ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Rt Pcr ◽  
Human Myotubes

In addition to generating movement, skeletal muscle may have a function as a secretory organ. The aim of the present study was to identify novel proteins with signaling capabilities secreted from skeletal muscle cells. IL-7 was detected in media conditioned by primary cultures of human myotubes differentiated from satellite cells, and concentrations increased with incubation time. By immunoblotting and real-time RT-PCR IL-7 expression was confirmed at both protein and mRNA levels. Furthermore, with immunofluorescence and specific antisera, multinucleated myotubes were found to coexpress IL-7 and myosin heavy chain. During differentiation of human myotubes from satellite cells, IL-7 expression increased at mRNA and protein levels. In contrast, mRNA expression of the IL-7 receptor was 80% lower in myotubes compared with satellite cells. Incubations with recombinant IL-7 under differentiation conditions caused ∼35% reduction in mRNA for the terminal myogenic markers myosin heavy chain 2 (MYH2) and myogenin (MYOG), suggesting that IL-7 may act on satellite cells to inhibit development of the muscle fiber phenotype. Alternative routes of cell development were investigated, and IL-7 increased migration of satellite cells by 40% after 48 h in a Transwell system, whereas cell proliferation remained unchanged. In vivo, real-time RT-PCR analysis of musculus vastus lateralis ( n = 10) and musculus trapezius ( n = 7) biopsies taken from male individuals undergoing a strength training program demonstrated that after 11 wk mean IL-7 mRNA increased by threefold ( P = 0.01) and fourfold ( P = 0.04), respectively. In conclusion, we have demonstrated that IL-7 is a novel myokine regulated both in vitro and in vivo, and it may play a role in the regulation of muscle cell development.

The importance of subfragment 2 and C-terminus of myosin heavy chain for thick filament assembly in skeletal muscle cells

2014 ◽  
Vol 86 (4) ◽  
pp. 459-467 ◽  
Author(s):  
Koichi Ojima ◽  
Mika Oe ◽  
Ikuyo Nakajima ◽  
Masahiro Shibata ◽  
Susumu Muroya ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Cells ◽  
Thick Filament ◽  
Skeletal Muscle Cells ◽  
Filament Assembly ◽  
C Terminus

Extracts of Hymenocardia acida ameliorate insulin resistance in skeletal muscle cells

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
II Ezeigbo ◽  
C Wheeler-Jones ◽  
S Gibbons ◽  
ME Cleasby
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Ameliorate Insulin Resistance

TGFß regulates metabolism of human skeletal muscle cells by miRNAs

2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells
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