scholarly journals Soluble Insulin Receptor Ectodomain Is Elevated in the Plasma of Patients With Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (8) ◽  
pp. 2028-2035 ◽  
Keyword(s):  
Insulin Receptor ◽  
Soluble Insulin ◽  
Patients With Diabetes ◽  
Soluble Insulin Receptor

scholarly journals Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection

2019 ◽  
Vol 10 ◽  
Author(s):  
Yamil Gerena ◽  
Raissa Menéndez-Delmestre ◽  
Andrea Delgado-Nieves ◽  
Joyce Vélez ◽  
Jarold Méndez-Álvarez ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hiv Infection ◽  
Insulin Receptor ◽  
Neurocognitive Dysfunction ◽  
Soluble Insulin ◽  
Soluble Insulin Receptor

scholarly journals Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women

2015 ◽  
Vol 21 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Yamil Gerena ◽  
Raissa Menéndez-Delmestre ◽  
Richard L. Skolasky ◽  
Rosa M. Hechavarria ◽  
Sebastián Pérez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cognitive Impairment ◽  
Insulin Receptor ◽  
Soluble Insulin ◽  
Hiv Seropositive ◽  
Soluble Insulin Receptor

Abstract 608: Circulating Soluble Insulin Receptor Level Is Associated With Left Ventricular Hypertrophy And Cardiac-dysfunction Independent Of Blood Pressure And Glucose

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Yasunori Takata ◽  
Junichi Funada ◽  
Go Hiasa ◽  
Yuji Matsumoto ◽  
Sumiko Sato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Insulin Receptor ◽  
Cardiac Dysfunction ◽  
Ventricular Hypertrophy ◽  
Fasting Glucose ◽  
Underlying Mechanism ◽  
Left Ventricular ◽  
Soluble Insulin ◽  
Soluble Insulin Receptor

Recent studies have demonstrated that both insulin resistance (IR) and diabetes were the critical risk factors of heart failure (HF). Importantly, it is reported the high prevalence of previously unknown left ventricular dysfunction including the prevalence of HF preserved EF (HFPEF) in diabetic subjects. However, the underlying mechanism and a biomarker have not been well defined. To identify underlying mechanism and candidate biomarker of HF in subjects with type 2 diabetes (T2DM), we performed retrospective study of 143 T2DM and 181 non-diabetic subjects. We evaluated cardiac function by echocardiography measuring left ventricular ejection fraction (LVEF), left ventricular mass index (LVMi) and the ratio of early transmitral flow velocity to tissue doppler early diastolic mitral annular velocity (E/e’). Here we demonstrate that plasma soluble insulin receptor (sIR), a novel biomarker of diabetes, was associated with left ventricular hypertrophy (LVH) and cardiac-dysfunction. Simple regression analysis revealed that circulating sIR was positively correlated with fasting glucose and negatively correlated with fasting insulin. Furthermore, sIR was positively correlated with LVMi and E/e’, and inversely correlated with LVEF ( R =0.25; p <0.01, R =0.22, p =0.03, R =-0.19; p =0.02, respectively). Moreover, multivariable regression analysis revealed that sIR was associated with LVMi, E/e’ and LVEF after adjustment for age, gender, BMI, plasma fasting glucose, systolic blood pressure, and eGFR in subjects with T2DM ( β = 0.26; p <0.01, β =0.25; p =0.02, β =-0.23; p <0.01,respectively). It is reported that circulating sIR is associated with cleavage of the extracellular domain of insulin receptor and sIR binds to circulating insulin. Thus, our results suggest the possibility that the influence of sIR on insulin signaling may be involved in LVH and cardiac-dysfunction in subjects with T2DM.

scholarly journals High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

FEBS Letters ◽  
2000 ◽  
Vol 479 (1-2) ◽  
pp. 15-18 ◽  
Author(s):  
Peter A. Hoyne ◽  
Leah J. Cosgrove ◽  
Neil M. McKern ◽  
John D. Bentley ◽  
Neva Ivancic ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Leucine Zipper ◽  
Insulin Binding ◽  
Extracellular Domain ◽  
High Affinity ◽  
Soluble Insulin ◽  
Soluble Insulin Receptor
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