scholarly journals Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

Diabetes ◽  
2007 ◽  
Vol 56 (6) ◽  
pp. 1615-1622 ◽  
Author(s):  
S. Fujita ◽  
B. B. Rasmussen ◽  
J. G. Cadenas ◽  
M. J. Drummond ◽  
E. L. Glynn ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Age Related ◽  
Muscle Protein Metabolism

scholarly journals Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia

2011 ◽  
Vol 301 (5) ◽  
pp. R1408-R1417 ◽  
Author(s):  
E. Lichar Dillon ◽  
Shanon L. Casperson ◽  
William J. Durham ◽  
Kathleen M. Randolph ◽  
Randall J. Urban ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Older Individuals ◽  
Skeletal Muscle Protein ◽  
Age Related ◽  
Muscle Protein Metabolism

The combination of increasing blood flow and amino acid (AA) availability provides an anabolic stimulus to the skeletal muscle of healthy young adults by optimizing both AA delivery and utilization. However, aging is associated with a blunted response to anabolic stimuli and may involve impairments in endothelial function. We investigated whether age-related differences exist in the muscle protein anabolic response to AAs between younger (30 ± 2 yr) and older (67 ± 2 yr) adults when macrovascular and microvascular leg blood flow were similarly increased with the nitric oxide (NO) donor, sodium nitroprusside (SNP). Regardless of age, SNP+AA induced similar increases above baseline ( P ≤ 0.05) in macrovascular flow (4.3 vs. 4.4 ml·min−1·100 ml leg−1 measured using indocyanine green dye dilution), microvascular flow (1.4 vs. 0.8 video intensity/s measured using contrast-enhanced ultrasound), phenylalanine net balance (59 vs. 68 nmol·min−1·100 ml·leg−1), fractional synthetic rate (0.02 vs. 0.02%/h), and model-derived muscle protein synthesis (62 vs. 49 nmol·min−1·100 ml·leg−1) in both younger vs. older individuals, respectively. Provision of AAs during NO-induced local skeletal muscle hyperemia stimulates skeletal muscle protein metabolism in older adults to a similar extent as in younger adults. Our results suggest that the aging vasculature is responsive to exogenous NO and that there is no age-related difference per se in AA-induced anabolism under such hyperemic conditions.

The Effect of Feeding during Recovery from Aerobic Exercise on Skeletal Muscle Intracellular Signaling

2014 ◽  
Vol 24 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Paul T. Reidy ◽  
Adam R. Konopka ◽  
J. Matthew Hinkley ◽  
Miranda K. Suer ◽  
Matthew P. Harber
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Aerobic Exercise ◽  
P38 Mapk ◽  
Protein Metabolism ◽  
Intracellular Signaling ◽  
Muscle Protein ◽  
Mapk Signaling ◽  
Skeletal Muscle Protein ◽  
Muscle Protein Metabolism

We previously reported an increase in skeletal muscle protein synthesis during fasted and fed recovery from nonexhaustive aerobic exercise (Harber et al., 2010). The current study examined skeletal muscle intracellular signaling in the same subjects to further investigate mechanisms of skeletal muscle protein metabolism with and without feeding following aerobic exercise. Eight males (VO2peak: 52 ± 2 ml−1.kg−1.min−1) performed 60-min of cycle ergometry at 72 ± 1% VO2peak on two occasions in a counter-balanced design. Exercise trials differed only in the postexercise nutritional intervention: EX-FED (5kcal, 0.83g carbohydrate, 0.37g protein, 0.03g fat per kg body weight) and EX-FAST (noncaloric, isovolumic placebo) ingested immediately and one hour after exercise. Muscle biopsies were obtained from the vastus lateralis at rest (on a separate day) and two hours postexercise to assess intracellular signaling via western blotting of p70S6K1, eEF2, 4EBP1, AMPKα and p38 MAPK. p70S6K1 phosphorylation was elevated (p < .05) in EX-FED relative to REST and EX-FAST. eEF2, 4EBP1, AMPKα and p38 MAPK signaling were unaltered at 2h after exercise independent of feeding status when expressed as the ratio of phosphorylated to total protein normalized to actin. These data demonstrate that feeding after a nonexhaustive bout of aerobic exercise stimulates skeletal muscle p70S6K1 intracellular signaling favorable for promoting protein synthesis which may, as recent literature has suggested, better prepare the muscle for subsequent exercise bouts. These data provide further support into the role of feeding on mechanisms regulating muscle protein metabolism during recovery from aerobic exercise.

scholarly journals Insulin resistance of muscle protein metabolism in aging

2006 ◽  
Vol 20 (6) ◽  
pp. 768-769 ◽  
Author(s):  
Blake B. Rasmussen ◽  
Satoshi Fujita ◽  
Robert R. Wolfe ◽  
Bettina Mittendorfer ◽  
Mona Roy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Metabolism

1460 Muscle protein metabolism of growing Holstein × Gyr heifers

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 709-709
Author(s):  
F. A. S. Silva ◽  
S. C. Valadares Filho ◽  
L. N. Rennó ◽  
S. A. Santos ◽  
D. Zanetti ◽  
...  
Keyword(s):  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Metabolism

Postabsorptive muscle protein metabolism in type 1 diabetic patients after pancreas transplantation

2000 ◽  
Vol 37 (4) ◽  
pp. 219-224 ◽  
Author(s):  
L. Luzi ◽  
L. Piceni Sereni ◽  
M. Spessot ◽  
R. Dodesini ◽  
M.R. Pastore ◽  
...  
Keyword(s):  
Protein Metabolism ◽  
Pancreas Transplantation ◽  
Muscle Protein ◽  
Diabetic Patients ◽  
Muscle Protein Metabolism ◽  
Type 1 Diabetic Patients

Resistance Exercise, Aging, Disuse, and Muscle Protein Metabolism

2021 ◽  
pp. 2249-2278
Author(s):  
James McKendry ◽  
Tanner Stokes ◽  
Jonathan C. Mcleod ◽  
Stuart M. Phillips
Keyword(s):  
Resistance Exercise ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Metabolism

scholarly journals Effect of Dietary Thyroxine on Muscle Protein Metabolism and Abdominal Fat Content in Broiler Chicken in Hot and Moderate Environments

1990 ◽  
Vol 61 (12) ◽  
pp. 1107-1112
Author(s):  
Kunioki HAYASHI ◽  
Shunichi KUKITA ◽  
Michiko MUKAI ◽  
Masaaki TOYOMIZU ◽  
Yuichiro TOMITA
Keyword(s):  
Protein Metabolism ◽  
Broiler Chicken ◽  
Muscle Protein ◽  
Abdominal Fat ◽  
Fat Content ◽  
Muscle Protein Metabolism
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