Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

Diabetes ◽  
2006 ◽  
Vol 55 (9) ◽  
pp. 2412-2418 ◽  
Author(s):  
Nadine L. Dudek ◽  
Helen E. Thomas ◽  
Lina Mariana ◽  
Robyn M. Sutherland ◽  
Janette Allison ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor ◽  
Β Cells

Expression of T Cell Receptor γ-Chain in Murine Cytotoxic T Cells: Analysis of a Highly Transcribed Nonrearranged Gene Cluster

Pathobiology ◽  
1988 ◽  
Vol 56 (4) ◽  
pp. 181-189
Author(s):  
Manfred Schulz ◽  
Gabi Lienhard ◽  
Fabio Rupp ◽  
Rolf M. Zinkernagel ◽  
Hans Hengartner
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gene Cluster ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

Nature ◽  
1994 ◽  
Vol 369 (6479) ◽  
pp. 407-410 ◽  
Author(s):  
Antonio Bertoletti ◽  
Alessandro Sette ◽  
Francis V. Chisari ◽  
Amalia Penna ◽  
Massimo Levrero ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor ◽  
Receptor Antagonists ◽  
Natural Variants

scholarly journals Target-Cell Contact Activates a Highly Selective Capacitative Calcium Entry Pathway in Cytotoxic T Lymphocytes

2000 ◽  
Vol 148 (3) ◽  
pp. 603-614 ◽  
Author(s):  
Adam Zweifach
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Target Cell ◽  
Calcium Influx ◽  
Cytotoxic T Cells ◽  
Cell Receptor ◽  
Cell Contact ◽  
Crac Channels

Calcium influx is critical for T cell activation. Evidence has been presented that T cell receptor–stimulated calcium influx in helper T lymphocytes occurs via channels activated as a consequence of depletion of intracellular calcium stores, a mechanism known as capacitative Ca2+ entry (CCE). However, two key questions have not been addressed. First, the mechanism of calcium influx in cytotoxic T cells has not been examined. While the T cell receptor–mediated early signals in helper and cytotoxic T cells are similar, the physiology of the cells is strikingly different, raising the possibility that the mechanism of calcium influx is also different. Second, contact of T cells with antigen-presenting cells or targets involves a host of intercellular interactions in addition to those between antigen–MHC and the T cell receptor. The possibility that calcium influx pathways in addition to those activated via the T cell receptor may be activated by contact with relevant cells has not been addressed. We have used imaging techniques to show that target-cell–stimulated calcium influx in CTLs occurs primarily through CCE. We investigated the permeability of the CTL influx pathway for divalent cations, and compared it to the permeability of CCE in Jurkat human leukemic T cells. CCE in CTLs shows a similar ability to discriminate between calcium, barium, and strontium as CCE in Jurkat human leukemic T lymphocytes, where CCE is likely to mediated by Ca2+ release–activated Ca2+ current (CRAC) channels, suggesting that CRAC channels also underlie CCE in CTLs. These results are the first determination of the mechanism of calcium influx in cytotoxic T cells and the first demonstration that cell contact–mediated calcium signals in T cells occur via depletion-activated channels.

scholarly journals RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition

Immunity ◽  
2012 ◽  
Vol 36 (1) ◽  
pp. 132-141 ◽  
Author(s):  
Mary A. Markiewicz ◽  
Erica L. Wise ◽  
Zachary S. Buchwald ◽  
Amelia K. Pinto ◽  
Biljana Zafirova ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Pancreatic Islets ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor ◽  
Receptor Recognition ◽  
Nkg2d Receptor

scholarly journals Single-cell T-cell receptor-β analysis of HLA-A*2402-restricted CMV- pp65-specific cytotoxic T-cells in allogeneic hematopoietic SCT

2013 ◽  
Vol 49 (1) ◽  
pp. 87-94 ◽  
Author(s):  
H Nakasone ◽  
Y Tanaka ◽  
R Yamazaki ◽  
K Terasako ◽  
M Sato ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Single Cell ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor

Mouse NK1.1+ cytotoxic T cells can be generated by IL-2 exposure from lymphocytes which express an intermediate level of T cell receptor

1998 ◽  
Vol 61 (2-3) ◽  
pp. 165-173 ◽  
Author(s):  
Yoshinori Ikarashi ◽  
Hidenori Maruoka ◽  
Kouichi Shinohara ◽  
Takashi Sugimura ◽  
Masaaki Terada ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cytotoxic T Cells ◽  
Cell Receptor ◽  
Intermediate Level
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