scholarly journals The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1890-1894 ◽  
Author(s):  
M. Desai ◽  
E. Zeggini ◽  
V. A. Horton ◽  
K. R. Owen ◽  
A. T. Hattersley ◽  
...  
Keyword(s):  
Tandem Repeats ◽  
Autoimmune Diabetes ◽  
Variable Number ◽  
Insulin Gene ◽  
Susceptibility Locus ◽  
Latent Autoimmune Diabetes

Variable Number of Tandem Repeats of the Insulin Gene Determines Susceptibility to Latent Autoimmune Diabetes in Adults

2004 ◽  
Vol 8 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Gloria Edith Cerrone ◽  
Mariela Caputo ◽  
Ariel Pablo Lopez ◽  
Claudio González ◽  
Carmen Massa ◽  
...  
Keyword(s):  
Tandem Repeats ◽  
Autoimmune Diabetes ◽  
Variable Number ◽  
Insulin Gene ◽  
Latent Autoimmune Diabetes

scholarly journals Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study

2007 ◽  
Vol 157 (6) ◽  
pp. 741-748 ◽  
Author(s):  
Dennis O Mook-Kanamori ◽  
J J Miranda Geelhoed ◽  
Eric A P Steegers ◽  
Jacqueline C M Witteman ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Tandem Repeats ◽  
Late Pregnancy ◽  
Variable Number ◽  
Growth Patterns ◽  
Insulin Gene ◽  
Abdominal Circumference ◽  
Fetal Life ◽  
Class Iii

ObjectiveThe aim of this study was to examine whether the insulin gene variable number of tandem repeats (INS VNTR) is associated with growth patterns in fetal life and infancy.Design and methodsThis study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. Fetal growth was assessed by ultrasounds in early, mid-, and late pregnancy. Anthropometry in infancy was assessed at birth and at the ages of 6 weeks, 6 months, and 14 months. DNA for genotyping of the INS VNTR promoter region was available in 859 children.ResultsThe genotype distribution was I/I 50.8%, I/III 40.0%, and III/III 9.2%. III/III individuals had a shorter gestational age (P<0.005 versus I/I) and a lower birth weight (P<0.05 versus I/I). There were no differences in birth weight after adjusting for gestational age. Class III homozygotes had a smaller abdominal circumference/head circumference (HC) ratio (P<0.005 versus I/I) in mid-pregnancy, but not in late pregnancy. Also, III/III subjects had a relative decrease in HC (SDS) from mid-pregnancy to the age of 14 months (P<0.05 versus I/I). No other differences in pre- and postnatal growth characteristics and patterns were found.ConclusionsClass III homozygotes were born at an earlier gestational age. No association was found between INS VNTR and birth weight adjusted for gestational age. Our data suggest that the III/III genotype may be associated with asymmetrical growth in mid-pregnancy, but not in late pregnancy.

Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women

2002 ◽  
Vol 77 (4) ◽  
pp. 666-668 ◽  
Author(s):  
Rosa M. Calvo ◽  
Dolores Tellerı́a ◽  
José Sancho ◽  
José L. San Millán ◽  
Héctor F. Escobar-Morreale
Keyword(s):  
Tandem Repeats ◽  
Variable Number ◽  
Insulin Gene ◽  
Spanish Women ◽  
Regulatory Polymorphism

The association of variable number of tandem repeats of the insulin gene with susceptibility to type 1 diabetes among Korean subjects

2010 ◽  
Vol 26 (6) ◽  
pp. 474-480 ◽  
Author(s):  
Hye Rim Chung ◽  
Sei Won Yang ◽  
Choong Ho Shin ◽  
Kyong Soo Park ◽  
Young Ah Lee ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Tandem Repeats ◽  
Variable Number ◽  
Insulin Gene

Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycystic ovary syndrome

2014 ◽  
Vol 75 (10) ◽  
pp. 1047-1052 ◽  
Author(s):  
Mei-Si Yan ◽  
Guan-Ying Liang ◽  
Bai-Rong Xia ◽  
Duan-Yang Liu ◽  
Dan Kong ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Tandem Repeats ◽  
Polycystic Ovary ◽  
Variable Number ◽  
Insulin Gene ◽  
Ovary Syndrome ◽  
Regulatory Polymorphism
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