scholarly journals Periodontal disease and cancer: Periodontal medicine in the multi-omics era

Author(s):  
Atsushi Nagai ◽  
Ryuji Sakagami
2017 ◽  
Vol 68 (6) ◽  
pp. 1252-1254
Author(s):  
Dorin Nicolae Gheorghe ◽  
Darian Rusu ◽  
Elena Herascu ◽  
Dora Maria Popescu ◽  
Petra Surlin ◽  
...  

The concept of periodontal medicine has been created by taking into consideration the strong connection between the development of the periodontal disease and other general conditions. The presence in blood, saliva and gingival fluid of certain inflammatory markers that are common for the two conditions � periodontitis and chronic hepatitis C, that can generate the appearance of the periodontal inflammation, can be an explication for the probable interconnection of the two conditions. The purpose of this pilot study is to investigate whether chronic hepatitis C can be a worsening factor for the development of the periodontal disease, by setting correlations between the periodontal pathology and some metabolic markers of both hepatitis C and periodontitis patients in comparison to periodontitis-only ones. Positive correlations would justify the expansion of the study for a larger group of patients and the dosage of inflammatory markers for biologic fluids such as blood, saliva and gingival fluid.


Author(s):  
Junima Rajkarnikar ◽  
Jemish Acharya ◽  
Karnika Yadav

Introduction: Tissue destruction of supporting periodontal tissues is mediated by an overreactive immune inflammatory response to bacteria in the subgingival environment. Tissue destruction in periodontitis occurs by the stimulatory action of pro inflammatory cytokines and proteolytic enzymes released by neutrophils, macrophages, and the action of bone resorption mediators, all of which are being regulated by B and T cells. Periodontitis act as a focus of infection and bacteria metastases through blood stream to various vital organs like heart, lungs, joints and amniotic fluid. Objective: To assess the awareness of periodontal medicine among medical students at a tertiary care center in Kathmandu. Methods: A total of 115 subjects were taken for the present study. Data was collected using a questionnaire which included questions used to assess the knowledge about periodontal diseases and its possible effects on systemic conditions. Results: Out of the total participants, 58 (50.4%) said that periodontal disease was not related to coronary heart diseases. Only 14 (12.2%) had an idea about the association of pre-term birth and periodontitis. While 86 (74.8%) knew the impact of diabetes on periodontium, only 34 (29.6%) said that there was an association between periodontitis and hospital acquired pneumonia. Conclusion: Knowledge about the association of periodontal disease with various systemic conditions is not satisfactory among the various medical students of this hospital.


2019 ◽  
Vol 98 (10) ◽  
pp. 1053-1062 ◽  
Author(s):  
J.D. Beck ◽  
P.N. Papapanou ◽  
K.H. Philips ◽  
S. Offenbacher

Periodontal medicine is a term used to describe how periodontal infection/inflammation may impact extraoral health. Periodontitis has been linked to over 50 systemic diseases and conditions. As part of the Journal of Dental Research’s Centennial Celebration, this narrative review discusses periodontal medicine research done over the past 100 y, with particular focus on the effects of periodontal disease on 3 pathological conditions: cardiovascular disease, diabetes mellitus, and adverse pregnancy outcomes. We selected 29 total studies that were the “first” of their kind, as they provided novel observations or contributed to shifting paradigms as well as important studies that made strong contributions to progress in understanding relationships to the systemic conditions. These studies were organized in an overview timeline and broken down into timelines by topic: cardiovascular disease ( n = 10), diabetes ( n = 12), and adverse pregnancy outcomes ( n = 7). Overall, the majority of cross-sectional, case-control, and longitudinal studies have revealed positive associations between poor periodontal status and cardiovascular disease, diabetes metabolic control, and a number of adverse pregnancy outcomes, and these associations are upheld in systematic reviews. Findings from randomized controlled trials testing the effects of periodontal therapy on systemic health outcomes were conflicting and inconsistent. While there has been a great deal of progress, we highlight lessons learned and make comments and suggestions on a number of key aspects, including the heterogeneity of case definitions of periodontal disease across studies, accounting for features of the periodontal phenotype that are most relevant to the biological link between periodontitis and systemic outcomes, the role of other comorbid inflammatory conditions, selection of study participants, and timing and intensity of the periodontal intervention.


2017 ◽  
Vol 262 (02) ◽  
pp. 2-76
Author(s):  
ME Monterde-Coronel ◽  
J Asbun-Bojalil ◽  
ME Hernández-Campos ◽  
P López-Sánchez ◽  
JL Aguilar-Faisal
Keyword(s):  

2014 ◽  
Author(s):  
Selin Kucukyurt Kaya ◽  
Demet Sahin ◽  
Sezen Buyukozdemir Askin ◽  
Ayse Ilhan ◽  
Sevgi Erdal ◽  
...  

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