scholarly journals Evaluation of Platelet-Rich Plasma (PRP) Combined with Autogenous Bone Graft for Periodontal Regeneration Therapy of Periodontal Intrabony Defects in Humans

2007 ◽  
Vol 49 (1) ◽  
pp. 71-76
Author(s):  
Takashi Tomiyama ◽  
Yoshihiro Iwamoto ◽  
Wakako Yoshizumi ◽  
Akemi Shimizu ◽  
Takayuki Kono ◽  
...  
Keyword(s):  
Bone Graft ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Intrabony Defects

scholarly journals Enamel Matrix Derivative and Autogenous Bone Graft for Periodontal Regeneration of Intrabony Defects in Humans: A Systematic Review and Meta-Analysis

Materials ◽  
2019 ◽  
Vol 12 (16) ◽  
pp. 2634 ◽  
Author(s):  
Marco Annunziata ◽  
Angelantonio Piccirillo ◽  
Francesco Perillo ◽  
Gennaro Cecoro ◽  
Livia Nastri ◽  
...  
Keyword(s):  
Bone Graft ◽  
Meta Analysis ◽  
Periodontal Regeneration ◽  
Autogenous Bone Graft ◽  
Enamel Matrix Derivative ◽  
Autogenous Bone ◽  
Controlled Trials ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Matrix Derivative

The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results. The aim of the present systematic review and meta-analysis was to assess the efficacy of EMD in combination with autogenous bone graft compared with the use of EMD alone for the regeneration of periodontal intrabony defects. A literature search in PubMed and in the Cochrane Central Register of Controlled Trials was carried out on February 2019 using an ad-hoc search string created by two independent and calibrated reviewers. All randomized controlled trials (RCTs) comparing a combination of EMD and autogenous bone graft with EMD alone for the treatment of periodontal intrabony defects were included. Studies involving other graft materials were excluded. The requested follow-up was at least 6 months. There was no restriction on age or number of patients. Standard difference in means between test and control groups as well as relative forest plots were calculated for clinical attachment level gain (CALgain), probing depth reduction (PDred), and gingival recession increase (RECinc). Three RCTs reporting on 79 patients and 98 intrabony defects were selected for the analysis. Statistical heterogeneity was detected as significantly high in the analysis of PDred and RECinc (I2 = 85.28%, p = 0.001; I2 = 73.95%, p = 0.022, respectively), but not in the analysis of CALgain (I2 = 59.30%, p = 0.086). Standard difference in means (SDM) for CALgain between test and control groups amounted to −0.34 mm (95% CI −0.77 to 0.09; p = 0.12). SDM for PDred amounted to −0.43 mm (95% CI −0.86 to 0.01; p = 0.06). SDM for RECinc amounted to 0.12 mm (95% CI −0.30 to 0.55. p = 0.57). Within their limits, the obtained results indicate that the combination of enamel matrix derivative and autogenous bone graft may result in non-significant additional clinical improvements in terms of CALgain, PDred, and RECinc compared with those obtained with EMD alone. Several factors, including the surgical protocol used (e.g. supracrestal soft tissue preservation techniques) could have masked the potential additional benefit of the combined approach. Further well-designed randomized controlled trials, with well-defined selection criteria and operative protocols, are needed to draw more definite conclusions.

Influence of the proportion of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects

Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Maria Nagata ◽  
Michel Messora ◽  
Roberta Okamoto ◽  
Natália Campos ◽  
Natália Pola ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Critical Size Defects

scholarly journals Use of Platelet-Rich Plasma in Autogenous Bone Graft in Implantology

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Souza Gleycielly da Mota Oliveira ◽  
Borges Carolina de Lima ◽  
Ratis Rosa Natalia Rendall dos Santos ◽  
Pedrosa Vivian Kelly Leite
Keyword(s):  
Bone Graft ◽  
Platelet Rich Plasma ◽  
Autogenous Bone Graft ◽  
Autogenous Bone

scholarly journals REGENERATION WITH AUTOGENOUS BONE GRAFT IN ANGULAR DEFECT

2021 ◽  
Vol 10 (3) ◽  
pp. 2871-2873
Author(s):  
Manish Dev Sejwal
Keyword(s):  
Periodontal Disease ◽  
Bone Graft ◽  
Periodontal Regeneration ◽  
Tissue Reaction ◽  
Autogenous Bone Graft ◽  
Osteogenic Potential ◽  
Autogenous Bone ◽  
Bony Defect ◽  
Periodontal Tissues ◽  
Grafting Materials

Untreated periodontal disease destroys the attachment apparatus and tooth supporting tissues, resulting in tooth loss. Periodontal treatment aims to stop the progression of periodontal disease while also regenerating periodontal tissues that have been lost due to periodontal disease. Periodontal regeneration appears to occur after treatment with autogenous bone grafts, according to data from clinical and histological research. Because it contains cells that engage in osteogenesis, autogenous bone possesses osteogenic potential. Autografts are also bioabsorbable (they are eventually replaced by the patient's own bone), nonallergenic (they produce little tissue reaction without an immunological reaction), simple to utilize, and inexpensive. Around autogenous bone graft particles, rapid revascularization occurs, and the graft can release growth and differentiation agents. When compared to open flap debridement, autogenous cancellous bone from the jaw is not suited for repairing intrabony periodontal abnormalities. An autogenous cortical bone (ACB) graft derived from the surgical site close to the intraosseous defect is beneficial because it eliminates the requirement for a second surgical site for repairing intraosseous periodontal deficiencies. For tissue regeneration, many therapeutic techniques are employed. Various grafting materials, such as autografts, allografts, xenografts, and alloplasts, have been used and therapeutically utilized among them. A case report on periodontal regeneration employing autogenous bone in the treatment of a periodontal intra-bony defect in the lower left molars is presented in this study.

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