Relationship between Tumor Size and Histological Invasiveness as Prognostic Indicators of Canine Mammary Epithelial Tumors

2007 ◽  
Vol 38 (3/4) ◽  
pp. 53-57
Author(s):  
Teruo ITOH ◽  
Kazuyuki UCHIDA ◽  
Kiyotaka KUSHIMA ◽  
Kenichi ISHIKAWA ◽  
Kazuhiro MIKAWA ◽  
...  
Keyword(s):  
Tumor Size ◽  
Mammary Epithelial ◽  
Prognostic Indicators ◽  
Epithelial Tumors

scholarly journals Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Wang ◽  
Bo Yuan ◽  
Zhen-huan Zhou ◽  
Wei-wei Han
Keyword(s):  
Prognostic Factors ◽  
Tumor Size ◽  
Survival Rates ◽  
Tumor Grade ◽  
Figo Stage ◽  
Cervical Adenocarcinoma ◽  
Stage Ii ◽  
Prognostic Indicators ◽  
Rank Test ◽  
Cancer Specific Survival

AbstractWe aimed to assess the clinicopathological features and to determine the prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology and end results database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were subsequently utilized to identify independent prognostic factors. A total of 3102 patients were identified. The enrolled patients were characterized by higher proportion of early FIGO stage (stage I: 65.9%; stage II: 14.1%), low pathological grade (grade I/II: 49.1%) and tumor size ≤ 4 cm (46.8%). The 5- and 10-year cancer-specific survival rates of these patients were 74.47% and 70.00%, respectively. Meanwhile, the 5- and 10-year overall survival (OS) rates were 71.52% and 65.17%, respectively. Multivariate analysis revealed that married status, surgery as well as chemotherapy were independent favorable prognostic indicators. Additionally, aged > 45, tumor grade III/IV, tumor size > 4 cm, advanced FIGO stage and pelvic lymph node metastasis (LNM) were unfavorable prognostic factors (all P < 0.01). Stratified analysis found that patients without surgery could significantly benefit from chemotherapy and radiotherapy. In addition, chemotherapy could significantly improve the survival in stage II–IV patients and radiotherapy could only improve the survival in stage III patients (all P < 0.01). Marital status, age, grade, tumor size, FIGO stage, surgery, pelvic LNM and chemotherapy were significantly associated with the prognosis of cervical AC.

AB001. OA01.01: Tumor size as a prognostic factor in limited stage thymic epithelial tumors: a multicenter analysis

Mediastinum ◽  
2018 ◽  
Vol 2 ◽  
pp. AB001-AB001
Author(s):  
Jae Kwang Yun ◽  
Hyeong Ryul Kim ◽  
Geun Dong Lee ◽  
Su Kyung Hwang ◽  
Se Hoon Choi ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Tumor Size ◽  
Thymic Epithelial Tumors ◽  
Limited Stage ◽  
Epithelial Tumors ◽  
Multicenter Analysis

Combined Evaluation of Expression of CXCR4 and Nrf2 as Prognostic Factor for Patients with Gastric Carcinoma

2018 ◽  
Vol 18 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Shuo Yu ◽  
Tao Wu ◽  
Jia Wang ◽  
Chuantao Cheng ◽  
Jing Wang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gastric Carcinoma ◽  
Distant Metastasis ◽  
Tumor Size ◽  
Histological Grade ◽  
Prognostic Indicators ◽  
Related Factor ◽  
Depth Of Invasion ◽  
Tissue Specimens ◽  
Nrf2 Expression

Background: CXC Chemokine Receptor 4 (CXCR4) and NFE–related factor 2 (Nrf2) have been observed implicated with cell malignant behavior of human cancers. </P><P> Aims: In this study, we detected their expression in gastric carcinoma (GC) tissue specimens and related the result with clinicopathological data and patient survival. Methods: 120 GC and compared normal tissue specimens were processed to analyse the expression of CXCR4 and Nrf2. We found that the expression of CXCR4 and Nrf2 was dramatically increased in GC tissues when compared to the distant non-cancer tissues (P<0.05). CXCR4 overexpression was associated with the depth of invasion (P= 0.006) Histological grade (P=0.018) TNMstage (P= 0.021) lymph node metastasis (P < 0.001) and distant metastasis (P=0.026), whereas overexpression of Nrf2 protein was significantly associated with tumor size (P=0.045), Histological grade (P=0.026), TNMstage (P= 0.020), lymph node metastases (P < 0.001) and distant metastasis (P=0.008). Furthermore, we observed a significant co-expression of CXCR4 and Nrf2 expression in GC specimens. Results: In the survival part, we found that GC patients with CXCR4+ and Nrf2+ had worse outcomes. The significant prognostic indicators are age, tumor size, histological grade, TNMstage, CXCR4, Nrf2, and coexpression of CXCR4 and Nrf2 in GC patients. Multivariate analysis showed that TNMstage and CXCR4+/Nrf2+ expression were risk factors. Above all we come to the conclusion that the expression of CXCR4 might partly be regulated by the level of Nrf2 and both positive expressions suggest poor prognosis of GC patients.

Amelanotic Choroidal Nevus and Melanoma: Cytology, Tumor Size, and Pigmentation as Prognostic Indicators

2001 ◽  
Vol 78 (7) ◽  
pp. 483-491 ◽  
Author(s):  
DENNIS S. LEE ◽  
SHEILA F. ANDERSON ◽  
EVELYN M. PEREZ ◽  
JOHN C. TOWNSEND
Keyword(s):  
Tumor Size ◽  
Prognostic Indicators ◽  
Choroidal Nevus

scholarly journals Clinicopathological Characteristics and Prognostic Factors for Cervical Adenocarcinoma: A Population-Based Study

2020 ◽  
Author(s):  
Min Wang ◽  
Zhen-huan Zhou ◽  
Wei-wei Han
Keyword(s):  
Prognostic Factors ◽  
Tumor Size ◽  
Hazard Analysis ◽  
Figo Stage ◽  
Population Based ◽  
Clinicopathological Characteristics ◽  
Cervical Adenocarcinoma ◽  
Stage Ii ◽  
Prognostic Indicators ◽  
Rank Test

Abstract Objective: We aimed to assess the clinicopathological features and determine prognostic factors of cervical adenocarcinoma (AC).Methods: Relevant data were extracted from Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were utilized to identify independent prognostic factorsResults: A total of 3102 patients were identified. The higher proportion of patients with early FIGO stage (stage I: 69.4%; stage II: 14.1%), low pathological grade (grade I/II: 49.1%) and tumor size≤4cm (46.8%). The 5- and 10-year CSS rates were 74.47% and 70.00%. Meanwhile, the 5- and 10-year OS rates were 71.52% and 65.17%. Multivariate analysis found that married, surgery as well as chemotherapy were independent favorable prognostic indicators. Additionally, aged ˃45, grade III/IV, tumor size ˃4cm, advanced FIGO stage, pelvic lymph node metastasis (LNM) were unfavorable prognostic factors (all P<0.001). Stratified analysis found that patients without surgery could benefit significantly from chemotherapy and radiotherapy. In addition, chemotherapy could significantly improved survival in stage II-IV patients and radiothrapy only improved stage III patients (all P < 0.01).Conclusion: Marital status, age, grade, tumor size, FIGO stage, pelvic LNM, surgery and chemotherapy were significantly associated with prognosis of cervical AC.

scholarly journals LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Claudia Tito ◽  
Federica Ganci ◽  
Andrea Sacconi ◽  
Silvia Masciarelli ◽  
Giulia Fontemaggi ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lipid Metabolism ◽  
Tumor Suppressor ◽  
Functional Characterization ◽  
Gene Signature ◽  
Prognostic Indicators ◽  
Migration Ability ◽  
Aberrant Expression ◽  
Thymic Epithelial Tumors ◽  
Epithelial Tumors

Abstract Long non-coding RNAs are emerging as new molecular players involved in many biological processes, such as proliferation, apoptosis, cell cycle, migration, and differentiation. Their aberrant expression has been reported in variety of diseases. The aim of this study is the identification and functional characterization of clinically relevant lncRNAs responsible for the inhibition of miR-145-5p, a key tumor suppressor in thymic epithelial tumors (TETs). Starting from gene expression analysis by microarray in a cohort of fresh frozen thymic tumors and normal tissues, we identified LINC00174 as upregulated in TET. Interestingly, LINC00174 expression is positively correlated with a 5-genes signature in TETs. Survival analyses, performed on the TCGA dataset, showed that LINC00174 and its associated 5-genes signature are prognostic in TETs. Specifically, we show that LINC00174 favors the expression of SYBU, FEM1B, and SCD5 genes by sponging miR-145-5p, a well-known tumor suppressor microRNA downregulated in a variety of tumors, included TETs. Functionally, LINC00174 impacts on cell migration and lipid metabolism. Specifically, SCD5, one of the LINC00174-associated genes, is implicated in the control of lipid metabolism and promotes thymic cancer cells migration. Our study highlights that LINC00174 and its associated gene signature are relevant prognostic indicators in TETs. Of note, we here show that a key controller of lipid metabolism, SCD5, augments the migration ability of TET cells, creating a link between lipids and motility, and highlighting these pathways as relevant targets for the development of novel therapeutic approaches for TET.

scholarly journals Combination of preoperative fibrinogen and neutrophil to lymphocyte ratio is a predictive prognostic factor in ESCC and AEG systematic review

2019 ◽  
Vol 39 (10) ◽  
Author(s):  
Guo Tianxing ◽  
Pan Xiaojie ◽  
Zhu Lihuan ◽  
Huang Yangyun
Keyword(s):  
Cancer Progression ◽  
Tumor Size ◽  
Esophagogastric Junction ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Indicators ◽  
Pathological Stage ◽  
Clinical Value ◽  
Curative Surgery ◽  
Lymphocyte Ratio ◽  
Prognosis Indicator

Abstract Objective: Cancer-associated systemic inflammation response and hyperfibrinogenemia play crucial roles in cancer progression and prognosis. In the present study, we assessed the clinical value of the preoperative fibrinogen and the neutrophil to lymphocyte ratio (NLR) in patients with esophageal squamous cell carcinoma (ESCC) and adenocarcinoma of the esophagogastric junction (AEG). Methods: Three hundred and fifty-six patients who underwent curative surgery were retrospectively analyzed. Univariate and Multivariate Cox analyses were performed to evaluate the prognostic indicators for overall survival (OS). The optimization cut-off values for fibrinogen and the NLR were 3.09 g/l and 1.89, respectively. The fibrinogen and the NLR (F-NLR) index was 2 for patients with high fibrinogen (≥3.09 g/l) and elevated NLR (≥1.89), whereas those with one or neither were indexed as 1 or 0, respectively. Results: The F-NLR score was significantly associated with tumor size (P&lt;0.001), and pathological stage (P=0.010). The 5-year OS rates in F-NLR groups 0, 1 and 2 were 69.1, 42.6, and 31.9%, respectively (P&lt;0.001). Multivariate analysis showed that the tumor size (P&lt;0.001), pathological stage (P&lt;0.001), and F-NLR (P&lt;0.001) were independent prognostic factors for OS. Conclusions: The preoperative F-NLR score is an independent prognosis indicator for patients with ESCC and AEG.

Sign in / Sign up

Export Citation Format

Share Document