scholarly journals An M-CSF Receptor c-Fms Antibody Inhibits Mechanical Stress–Induced Root Resorption during Orthodontic Tooth Movement in Mice

2009 ◽  
Vol 79 (5) ◽  
pp. 835-841 ◽  
Author(s):  
Hideki Kitaura ◽  
Yuji Fujimura ◽  
Masako Yoshimatsu ◽  
Toshiko Eguchi ◽  
Haruka Kohara ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Mechanical Stress ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Coil Spring ◽  
Potential Therapeutic Target ◽  
Local Site ◽  
Scanning Electron

Abstract Objective: To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model. Materials and Methods: We used orthodontic tooth movement in which an Ni-Ti coil spring was inserted between the upper incisors and the upper first molar. Root resorption occurred in this model. Anti-c-Fms antibody was injected daily into a local site for 12 days during mechanical loading. Odontoclastogenesis and root resorption were assessed by histology and scanning electron microscopy. Results: The anti-c-Fms antibody significantly inhibited odontoclastogenesis and root resorption during orthodontic tooth movement. Conclusion: M-CSF and/or its receptor is a potential therapeutic target in mechanical stress– induced odontoclastogenesis, and injection of an anti-c-Fms antibody might be useful for inhibition of mechanical stress–induced root resorption during orthodontic tooth movement.

Scanning Electron Microscopy Evaluation of Dental Root Resorption Associated With Granuloma

2015 ◽  
Vol 21 (5) ◽  
pp. 1264-1270 ◽  
Author(s):  
Manila Chieruzzi ◽  
Stefano Pagano ◽  
Carlo De Carolis ◽  
Stefano Eramo ◽  
José M. Kenny
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Root Resorption ◽  
Root Apex ◽  
Average Diameter ◽  
Root Structure ◽  
Human Teeth ◽  
Periapical Lesions ◽  
Carious Lesions ◽  
Scanning Electron

AbstractThe inflammatory resorption of dental root apex (i.e., the process of removal of cementum and/or dentine through the activity of resorbing cells) may show different configurations and damage the apical root structure. As knowing the morphology of resorption areas of human teeth is essential for the success of endodontic treatments, we investigated the apical resorption by scanning electron microscopy, focusing on roots with granulomas. A total of 30 teeth (with penetrating carious lesions and chronic periapical lesions) were examined, the apical third of the roots were removed and analyzed to estimate periforaminal and foraminal resorption, shape and morphology of foramen resorption, centering of the periforaminal resorption area, and diameters of each apical foramen. Periforaminal resorption was present in all samples, whereas foraminal resorption was present in 92% of cases (mainly funnel shaped). Lacunae were observed in the foraminal resorption area with an average diameter of 35±14 μm. The major and minor diameters of the foramina in teeth with resorption were 443 and 313 μm, respectively (higher than in healthy teeth). This result indicates an expansion of the apical diameters caused by the pathology, which could encourage a different clinical instrumentation for these teeth.

scholarly journals Scanning Electron Microscopy of Root Resorption of Feline Teeth

2004 ◽  
Vol 66 (12) ◽  
pp. 1579-1581 ◽  
Author(s):  
Shigeo OHBA ◽  
Masato KUWABARA ◽  
Hiroshi KAMATA ◽  
Masayuki YUKAWA ◽  
Hideo KIBA
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Root Resorption ◽  
Scanning Electron

scholarly journals Standard Versus Real Versus Fake Braces: Design And Microstructure Comparison

2017 ◽  
Vol 16 (2) ◽  
Author(s):  
Siti Hajjar Nasir ◽  
Noraini Abu Bakar ◽  
Rosdiyana Samad
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
High Resolution ◽  
Surface Texture ◽  
Tooth Movement ◽  
Central Incisor ◽  
Surface Textures ◽  
Tooth Structure ◽  
Conventional Brackets ◽  
Scanning Electron

Introduction: The growing demand for orthodontic braces among Malaysian community has led to the development of "fake" and "real" braces. "Fake" braces refer to braces that are worn as costume and are not bonded to teeth hence unable to produce movement of teeth. "Real" braces refer to braces that are bonded to tooth structure and are able to produce tooth movement. The braces are bonded by unqualified practitioners with no formal dental education and they provide braces treatment in unlicensed premises such as hotel rooms or patients' own homes. Materials and Methods: This study was conducted to investigate the design and microstructure of several types of "fake", "real" and standard braces. A total of 9 upper right central incisor brackets were scanned using high resolution scanning electron microscopy (SEM) with magnifications of 65x, 500x and 1000x. Brackets slot heights and depths were also measured to compare slot dimensions between "fake", "real" and standard braces. Results: The surface textures of "fake" and "real" braces were noticeably more granular and unpolished as compared to conventional brackets. Furthermore, all "fake" and some "real" braces upper right central incisor bracket designs were distinctly different from the standard braces. The slot dimensions of "fake" and "real" braces were also significantly larger that standard braces. Conclusion(s): In conclusion, the surface texture and morphology of "fake" and "real" braces were crude and different when compared to conventional brackets.

scholarly journals Different Resorptive Patterns of Two Avulsed and Replanted Upper Central Incisors Based on Scanning Electron Microscopy and Stereomicroscopic Analysis: A Case Report

2020 ◽  
Vol 10 (10) ◽  
pp. 3551
Author(s):  
Marta Mazur ◽  
Roberto Marasca ◽  
Livia Ottolenghi ◽  
Iole Vozza ◽  
Francesco Covello ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Root Resorption ◽  
Dental Trauma ◽  
Permanent Tooth ◽  
Single Individual ◽  
Factors Affecting ◽  
Tooth Avulsion ◽  
Depth Analysis ◽  
Scanning Electron

Dental trauma resulting in permanent tooth avulsion commonly affects the young population. The prognosis of replantation after avulsion depends on the natural history of inflammatory and replacement resorption. Several risk factors for type and onset of external resorption have been defined. This case study describes different resorptive patterns observed in two upper central incisors belonging to a single individual, avulsed in the same moment, and replanted after thirty-six hours of dry storage. The roots were analyzed by scanning electron microscopy and stereomicroscope imaging, to obtain an in-depth analysis of the resorptive pattern. The aim of this report is to: (i) underline the high variability in the incidence of root resorption after replantation across and within types of teeth and resorption; and (ii) underline the possible concurrence of different factors affecting the onset and type of resorptive pattern. In conclusion, an unpredictable pattern of resorption may account for the poor prognosis when teeth are replanted outside the current recommendations.

scholarly journals Injectable RANKL sustained release formulations to accelerate orthodontic tooth movement

2019 ◽  
Vol 42 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Joy H Chang ◽  
Po-Jung Chen ◽  
Michael R Arul ◽  
Eliane H Dutra ◽  
Ravindra Nanda ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Root Resorption ◽  
Volume Fraction ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
Hydroxyethyl Cellulose ◽  
Poly Lactic Acid ◽  
Tartrate Resistant Acid Phosphatase ◽  
Coil Spring ◽  
Control Groups

Summary Background Accelerating orthodontic tooth movement (OTM) through biologically effective methods, such as increasing osteoclast-mediated alveolar resorption, could effectively shorten treatment time. Objective To evaluate an injectable formulation containing receptor activator of nuclear factor kappa-B ligand (RANKL) on the OTM. Materials and methods We fabricated a RANKL formulation from 100 µl of 100 µg/ml RANKL adsorbed on 10 mg of poly(lactic acid-co-glycolic acid) microspheres embedded in a 10 wt% aqueous hydroxyethyl cellulose carrier gel. We characterized these formulations for the rate of RANKL release, and then tested for bioactivity using in vitro cell culture. In vivo OTM studies were conducted using 15 week old male Wistar rats for 14 days. We injected the RANKL formulations palatal to the left maxillary first molar and accomplished OTM with a nickel–titanium (NiTi) coil spring applying 5–8 g force. Control groups involved the application of NiTi coil spring with and without placebo formulation. The outcome measure included the distance of tooth movement, bone volume fraction, tissue density, and root volume determined with micro-computed tomography. We determined the amount of osteoclast activity using tartrate-resistant acid phosphatase (TRAP) staining. Results These formulations were able to sustain the release of RANKL for more than 30 days, and the released RANKL showed a positive effect on mice osteoclast precursor cells (RAW 264.7). Reported injectable RANKL formulations were effective in accelerating OTM compared with other control groups, with 129.2 per cent more tooth movement than no formulation and 71.8 per cent more than placebo formulation, corresponding with a significant increase in the amount of TRAP activity. We did not observe any significant differences in root resorption between the groups. Conclusion Our study shows a significant increase in OTM with injectable formulations containing RANKL.

Scanning electron microscopy reveals severe external root resorption in the large periapical lesion

2016 ◽  
Vol 79 (6) ◽  
pp. 495-500 ◽  
Author(s):  
Kensuke Ookubo ◽  
Atsushi Ookubo ◽  
Masaki Tsujimoto ◽  
Kouji Sugimoto ◽  
Shizuka Yamada ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Root Resorption ◽  
Periapical Lesion ◽  
External Root Resorption ◽  
Scanning Electron

Pathogenesis of Human Hair Defects

1974 ◽  
Vol 32 ◽  
pp. 12-13
Author(s):  
P.S. Porter ◽  
T. Aoyagi ◽  
R. Matta
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Human Hair ◽  
Standard Techniques ◽  
Scanning Electron

Using standard techniques of scanning electron microscopy (SEM), over 1000 human hair defects have been studied. In several of the defects, the pathogenesis of the abnormality has been clarified using these techniques. It is the purpose of this paper to present several distinct morphologic abnormalities of hair and to discuss their pathogenesis as elucidated through techniques of scanning electron microscopy.

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