Nonvariceal Upper Gastrointestinal Bleeding

2020 ◽  
Author(s):  
John R. Saltzman ◽  
Wasif Abidi
Keyword(s):  
Differential Diagnosis ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Endoscopic Therapy ◽  
Scoring Systems ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Treatment Regimens ◽  
Consensus Statements ◽  
Ligament Of Treitz

Gastrointestinal (GI) bleeding that is proximal to the ligament of Treitz is considered upper GI bleeding (UGIB). UGIB can be further divided into variceal and nonvariceal, differentiated by etiology, presentation, management, and mortality. This review of nonvariceal UGIB addresses the epidemiology, diagnosis, treatment (including endoscopic therapy), prognosis, and differential diagnosis. Recommendations presented are evidence based and consistent with consensus statements and society guidelines. Figures show stigmata of recent hemorrhage, endoscopic therapy, peptic ulcer disease, Mallory-Weiss syndrome, angiodysplasia, Dieulafoy lesion, and arterioenteric fistula. Tables list the manifestation of GI bleeding and the presumed source of the bleeding, clues in the symptom and presentation of the patient that may suggest the diagnosis, medical history and physical examination findings that can suggest a specific diagnosis, a comparison of different prognostic scoring systems, differential diagnosis of UGIB, various etiologies of peptic ulcer disease, and treatment regimens for Helicobacter pylori. This review contains 7 highly rendered figures, 10 tables, and 85 references

Nonvariceal Upper Gastrointestinal Bleeding

2020 ◽  
Author(s):  
John R. Saltzman ◽  
Wasif Abidi
Keyword(s):  
Differential Diagnosis ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Endoscopic Therapy ◽  
Scoring Systems ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Treatment Regimens ◽  
Consensus Statements ◽  
Ligament Of Treitz

Gastrointestinal (GI) bleeding that is proximal to the ligament of Treitz is considered upper GI bleeding (UGIB). UGIB can be further divided into variceal and nonvariceal, differentiated by etiology, presentation, management, and mortality. This review of nonvariceal UGIB addresses the epidemiology, diagnosis, treatment (including endoscopic therapy), prognosis, and differential diagnosis. Recommendations presented are evidence based and consistent with consensus statements and society guidelines. Figures show stigmata of recent hemorrhage, endoscopic therapy, peptic ulcer disease, Mallory-Weiss syndrome, angiodysplasia, Dieulafoy lesion, and arterioenteric fistula. Tables list the manifestation of GI bleeding and the presumed source of the bleeding, clues in the symptom and presentation of the patient that may suggest the diagnosis, medical history and physical examination findings that can suggest a specific diagnosis, a comparison of different prognostic scoring systems, differential diagnosis of UGIB, various etiologies of peptic ulcer disease, and treatment regimens for Helicobacter pylori. This review contains 7 highly rendered figures, 10 tables, and 85 references

A cost effective strategy for managing GI bleeding secondary to peptic ulcer disease

1995 ◽  
Vol 108 (4) ◽  
pp. A18 ◽  
Author(s):  
I Hussain ◽  
WH Farrar ◽  
EJ Sofian ◽  
TF Bader ◽  
JD Strom ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Cost Effective ◽  
Effective Strategy ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Cost Effective Strategy

Gastrointestinal illness

2019 ◽  
pp. 647-668
Author(s):  
Ingo Hartlapp
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Clinical Presentation ◽  
Gastrointestinal Illness ◽  
Gi Bleeding ◽  
Gi Tract ◽  
Specific Diagnosis ◽  
Low Resource Settings ◽  
Ulcer Disease ◽  
Clinical Presentations

This chapter gives an overview of the most important clinical presentations involving the gastrointestinal (GI) tract commonly seen in the field, including hepatitis, cirrhosis, peptic ulcer disease, and GI bleeding, from typical clinical presentation to specific diagnosis and treatment. Recognizing the challenges with diagnosis and management of such conditions in humanitarian settings, this chapter provides doctors who practise in low-resource settings with the guidance to implement more specialized GI medicine

scholarly journals Non-perforated peptic ulcer disease: multidetector CT findings, complications, and differential diagnosis

2017 ◽  
Vol 8 (5) ◽  
pp. 455-469 ◽  
Author(s):  
Massimo Tonolini ◽  
Anna Maria Ierardi ◽  
Elena Bracchi ◽  
Paolo Magistrelli ◽  
Adriana Vella ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Multidetector Ct ◽  
Perforated Peptic Ulcer ◽  
Ulcer Disease ◽  
Ct Findings

scholarly journals Validation of prognostic scoring systems for predicting 30-day mortality in perforated peptic ulcer disease

2019 ◽  
Vol 35 (4) ◽  
pp. 252-258
Author(s):  
Shaili Patel ◽  
Devanshu Kalra ◽  
Samir Kacheriwala ◽  
Mihir Shah ◽  
Dipesh Duttaroy
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Scoring Systems ◽  
Perforated Peptic Ulcer ◽  
Ulcer Disease ◽  
Prognostic Scoring Systems

Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer-related bleeding: multicenter international registry

Endoscopy ◽  
2020 ◽  
Vol 53 (01) ◽  
pp. 36-43
Author(s):  
Mohamed Hussein ◽  
Durayd Alzoubaidi ◽  
Miguel-Fraile Lopez ◽  
Michael Weaver ◽  
Jacobo Ortiz-Fernandez-Sordo ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Rescue Therapy ◽  
Case Series ◽  
Ulcer Bleeding ◽  
Peptic Ulcers ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Bleeding Peptic Ulcers ◽  
The Uk

Abstract Background Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and is associated with a 2 % – 17 % mortality rate in the UK and USA. Bleeding peptic ulcers account for 50 % of UGIB cases. Endoscopic intervention in a timely manner can improve outcomes. Hemostatic spray is an endoscopic hemostatic powder for GI bleeding. This multicenter registry was created to collect data prospectively on the immediate endoscopic hemostasis of GI bleeding in patients with peptic ulcer disease when hemostatic spray is applied as endoscopic monotherapy, dual therapy, or rescue therapy. Methods Data were collected prospectively (January 2016 – March 2019) from 14 centers in the UK, France, Germany, and the USA. The application of hemostatic spray was decided upon at the endoscopist’s discretion. Results 202 patients with UGIB secondary to peptic ulcers were recruited. Immediate hemostasis was achieved in 178/202 patients (88 %), 26/154 (17 %) experienced rebleeding, 21/175 (12 %) died within 7 days, and 38/175 (22 %) died within 30 days (all-cause mortality). Combination therapy of hemostatic spray with other endoscopic modalities had an associated lower 30-day mortality (16 %, P < 0.05) compared with monotherapy or rescue therapy. There were high immediate hemostasis rates across all peptic ulcer disease Forrest classifications. Conclusions This is the largest case series of outcomes of peptic ulcer bleeding treated with hemostatic spray, with high immediate hemostasis rates for bleeding peptic ulcers.

Clavulanic Acid in the Scope of Helicobacter pylori Treatment: A Literature Review and Beyond

2020 ◽  
Vol 15 ◽  
Author(s):  
Nasr Alrabadi ◽  
Iyad S. Albustami ◽  
Husam A. Abuhayyeh ◽  
Khaled M. El-Muwalla ◽  
Rama J. Alawneh ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Clavulanic Acid ◽  
Clinical Studies ◽  
Filamentous Form ◽  
Ulcer Disease ◽  
Treatment Regimens ◽  
Randomized Controlled Studies ◽  
H Pylori

Background: Helicobacter pylori (H.pylori) infection is the most common cause of peptic ulcer disease and it can be associated with many complications including malignancies. In clinical practice, some clinicians may use clavulanic acid (CA) in combination with amoxicillin or other beta-lactams as an addition to the standard treatment regimens. This practice may be made by habitual mistake, non-evidence based hypothetical assumptions, or by prescribing it as an alternative treatment. This review aims to expose the effect of CA against H.pylori infection and to review the possible mechanisms that may contribute to that effect. Methods: A PubMed and Google Scholar literature search was obtained on both pre-clinical and clinical studies related to CA and H.pylori infection. Results: Available clinical studies showed improvement in the eradication of H. pylori by about 10-20% when CA was added to the treatment regimens. This effect for CA could be related to several mechanisms including inhibition of H. pylori growth by binding to penicillin-binding proteins (PBPs), the transformation of H. pylori from the active filamentous form into coccoidal form, induction of the release of dopamine, modulation of immunological response towards H. pylori infection and its relationship with other microbiota. Randomized-controlled studies on patients with resistance H. pylori are needed. Moreover, In_vitro studies to evaluate the mechanisms by which CA may influence H. pylori are warranted. Conclusion: The presented literature suggests potential avenues for the use of CA in the management of peptic ulcer disease and H.pylori infection.

538 IMPROVING HELICOBACTER PYLORI TESTING IN PATIENTS WITH ACUTE UPPER GI BLEEDING DUE TO PEPTIC ULCER DISEASE (POSTER PRESENTATION)

2020 ◽  
Vol 158 (6) ◽  
pp. S-109
Author(s):  
Jessica Bernica ◽  
Rhonda A. Cole ◽  
Avegail G. Flores ◽  
Clark D. Hair ◽  
Ruben Hernaez ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Poster Presentation ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Upper Gi Bleeding ◽  
Upper Gi
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