Nonepithelial Esophageal Tumors: Leiomyomas and GI Stromal Tumors
Nonepithelial esophageal tumors can be classified into two groups. The most common group consists of GI stromal tumors (GISTs). The less common group consists of several tumors similar to tumors arising from soft tissues of other body parts (eg, lipomas, liposarcomas, leiomyomas, leiomyosarcomas, peripheral nerve sheath tumors). Differentiation between these two groups is based on the near-universal expression of CD117 in GISTs, as opposed to other spindle cell tumors. Although some of these tumors are asymptomatic and discovered accidentally during CT or endoscopies for other reasons, they often cause some unspecific symptoms (eg, bloating, dysphagia, early satiety). Contrast-enhanced CT with IV and oral contrast is the examination of choice to evaluate these tumors, as extent of the tumor and presence of metastatic disease can be determined. Surgical resection is generally recommended for tumors larger than 2 cm or symptomatic tumors. This review contains 4 figures, 2 tables, and 35 references. Key Words: GIST, leiomyoma, leiomyosarcoma, nonepithelial esophageal tumors, esophagus, diagnosis, treatment, follow-up