Treatment of Nail Bed Defects with Hard Palate Mucosal Grafts

2006 ◽  
Vol 10 (2) ◽  
pp. 69-72 ◽  
Author(s):  
Silvia Fernández-Mejía ◽  
Judith Domínguez-Cherit ◽  
Patricia Pichardo-Velázquez ◽  
Sergio González-Olvera
Keyword(s):  
Observational Study ◽  
Hard Palate ◽  
Nail Plate ◽  
Initial Experience ◽  
Nail Dystrophy ◽  
Nail Bed ◽  
Good Outcome ◽  
Excellent Growth ◽  
Surgical Recovery ◽  
Prospective Longitudinal

Background: Nail bed defects produce a nail plate dystrophy that is permanent and presents important cosmetic problems. To correct the defect, we used a hard palate mucosal graft. This is a procedure with encouraging outcomes for nail bed scars. Objective: To show our initial experience with the hard palate mucosal graft technique for correcting nail dystrophy or permanent onycholysis secondary to a nail bed scar. Methods: This was a prospective, longitudinal, descriptive, observational study. We included five patients with a traumatic nail bed scar and one patient with congenital dystrophy. Seven nails were treated using a hard palate mucosal graft. Results: All repaired nails had a good outcome, with excellent growth and improvement in nail dystrophy. The patients had surgical recovery in 2 weeks and tolerable pain. Conclusions: This is a relatively easy procedure for experienced surgeons to correct nail dystrophy secondary to a nail bed scar, with good to excellent results.

scholarly journals Nail changes in construction site workers: an observational study

2020 ◽  
Vol 9 (1) ◽  
pp. 84
Author(s):  
Nidhi Kamra ◽  
Sahil Sardana
Keyword(s):  
Observational Study ◽  
Preventive Measures ◽  
Nail Plate ◽  
Age Group ◽  
Construction Site ◽  
Nail Bed ◽  
Nail Changes ◽  
Group 10

Background: Nail changes are common in occupational labourers but no studies have been done pertaining to construction site workers. We studied nail changes in labourers working at various construction sites.Methods: 50 labourers of age group 10-65 years and both sexes were enrolled for the study. Changes in nail apparatus were studied by dividing into nail plate, nail bed and nail fold changes.Results: Males outnumbered females in our study. Most of the labourers were in age group of 10-25 years. Most common nail plate changes were Longitudinal ridging and discoloration of nail plate; nail bed were onycholysis, subungual hemorrhage, onycholysis and nail fold changes were absent cuticle and hang nail.Conclusions: Adequate preventive measures are required at construction site workplace to prevent long standing nail sequalae.

Ultrasound characterization of the nail bed in patients with systemic lupus erythematosus

Lupus ◽  
2021 ◽  
pp. 096120332098860
Author(s):  
Diana Ferrusquia-Toriz ◽  
Cristina Hernández-Díaz ◽  
Luis M Amezcua-Guerra ◽  
Lucio Ventura-Ríos ◽  
Violeta Higuera-Ortiz ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Raynaud’S Phenomenon ◽  
Nail Plate ◽  
Organ Damage ◽  
Healthy Individuals ◽  
Systemic Lupus ◽  
Nail Dystrophy ◽  
Nail Bed

Objective To characterize the ultrasound findings of the nail plate and nail bed in systemic lupus erythematosus (SLE) and its association with nail dystrophy. Methods Thirty-two SLE patients, 36 patients with osteoarthritis (OA) and 20 healthy individuals were studied. High-frequency linear ultrasound was performed in nails of the second to fifth fingers in all participants. Disease activity (SLEDAI-2K index), accrued organ damage (SLICC/ACR index), autoantibody profile, and Raynaud’s phenomenon were also assessed in SLE patients. Results Nail bed thickness in SLE patients was higher than in healthy individuals (1.25 ± 0.31 mm vs 1.17 ± 0.29 mm; P = 0.01) but lower than in OA (1.39 ± 0.37 mm; P < 0.001), while nail plate thickness was similar among groups. Nail dystrophy was found more frequently in SLE and OA than in healthy individuals. SLE patients with nail dystrophy were older than their counterparts with no dystrophy (39.4 ± 10.4 years vs 27.8 ± 5.6 years; P = 0.004), although nail dystrophy showed no association with SLICC/ACR, SLEDAI-2K, nail bed vascularity, or autoantibodies. Conclusions Nail bed in SLE patients is thicker than in healthy individuals but thinner than in OA patients. Nail dystrophy in SLE is associated with advanced age, but not with accrued organ damage, disease activity, Raynaud's phenomenon, or DIP synovitis assessed by ultrasound.

scholarly journals Bone Pain in Multiple Myeloma (BPMM)—A Protocol for a Prospective, Longitudinal, Observational Study

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1596
Author(s):  
Marta Diaz-delCastillo ◽  
Rebecca E. Andrews ◽  
Aritri Mandal ◽  
Thomas L. Andersen ◽  
Andrew D. Chantry ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Myeloma ◽  
Observational Study ◽  
Bone Turnover ◽  
Bone Pain ◽  
Subjective Experience ◽  
Prospective Longitudinal ◽  
Bone Turnover Biomarkers

Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospective, observational study (clinicaltrials.gov: NCT04273425), patients with suspected MM requiring a diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited to participate. Consenting patients answer seven standardized questionnaires assessing pain, quality of life and catastrophizing. Bone turnover biomarkers and inflammatory cytokines are measured in fasting serum samples, and bone innervation is evaluated in diagnostic biopsies. MM patients are invited to a follow-up upon completion of first line treatment. This will be the first deep characterization of pain in MM patients and its correlation with disturbances in bone innervation. Understanding how bone turnover and inflammation correlate to pain in MM is crucial to identify novel analgesic targets for this condition.

scholarly journals Initial Experience of the Levodopa–Entacapone–Carbidopa Intestinal Gel in Clinical Practice

2021 ◽  
Vol 11 (4) ◽  
pp. 254
Author(s):  
Mezin Öthman ◽  
Erik Widman ◽  
Ingela Nygren ◽  
Dag Nyholm
Keyword(s):  
Cardiac Arrest ◽  
Clinical Practice ◽  
Observational Study ◽  
Prospective Studies ◽  
Infusion Rate ◽  
Treatment Duration ◽  
Initial Experience ◽  
Morning Dose ◽  
Efficacy And Safety ◽  
User Friendliness

Patients in fluctuating stages of Parkinson’s disease (PD) require device-aided treatments. Continuous infusion of levodopa–carbidopa intestinal gel (LCIG) is a well-proven option in clinical practice. We now report the first clinical experience of levodopa–entacapone–carbidopa intestinal gel (LECIG) therapy. An observational study of the first patients to start LECIG in our clinic was performed. Twenty-four patients (11 females, 13 males) were included. The median age was 71.5 years, and the median duration since PD diagnosis was 15.5 years. The median treatment duration was 305 days. Median doses were: 6.0 mL as morning dose, 2.5 mL/h as infusion rate, and 1.0 mL as extra dose. Half of the patients were switched directly from LCIG. These patients express improvements in the size and weight of the pump. Furthermore, most of them considered the new pump to be improved regarding user-friendliness. Six patients discontinued LECIG, three due to diarrhea, one due to hallucinations and two deceased (one cardiac arrest and one COVID-19). LECIG has shown to be possible to use in patients with PD, efficacy and safety as expected. Patients are generally happy with the size and usability of the pump, but some technical improvements of the software are warranted, as well as larger, prospective studies.

scholarly journals Ultrasound Evaluation of the Effectiveness of the Use of Acitretin in the Treatment of Nail Psoriasis

2021 ◽  
Vol 10 (10) ◽  
pp. 2122
Author(s):  
Magdalena Krajewska-Włodarczyk ◽  
Zbigniew Żuber ◽  
Agnieszka Owczarczyk-Saczonek
Keyword(s):  
Morphological Changes ◽  
Nail Plate ◽  
Clinical Signs ◽  
Extensor Tendon ◽  
Control Group ◽  
Nail Bed ◽  
Nail Psoriasis ◽  
Ultrasound Evaluation ◽  
Tendon Thickness ◽  
Retinoid Treatment

The study aimed to evaluate the effect of retinoid treatment on the morphological changes in the nail apparatus in patients with nail psoriasis. Material and methods: 41 patients aged 32 to 64 with nail psoriasis, without clinical signs of psoriatic arthritis, started on acitretin 0.6 to 0.8 mg kg b.w./d, for six months and 28 people in the control group were included in the study. Both groups had ultrasound examination of fingernails and digital extensor tendon in the distal interphalangeal joints. In psoriatic patients, US examination was conducted before starting the treatment and after six months. A total of 685 nails were examined. Results: After six months of treatment, there was a reduction in the thickness of the nail bed and nail matrix (p = 0.046 and p = 0.031, respectively). The thickness of the nail plates decreased, although it was statistically insignificant (p = 0.059) and it was higher than in the control group (p = 0.034). The reduced severity of clinical nail changes after six months of retinoid treatment did not correlate with the reduction in extensor tendon thickness in any group of patients. Conclusions: In patients with nail psoriasis, acitretin treatment resulted in a rapid decrease in the thickness of the nail bed and matrix, but it did not affect the thickness of the nail plate after six months. There was no effect of acitretin on the digital extensor tendon thickness or the increased blood supply to the tendon area. The results of the study may indicate the usefulness of ultrasound nail examinations in patients with nail psoriasis not only to assess the advancement of morphological changes and response to treatment, but also to choose the potential treatment.

scholarly journals Analysis of Arterial Blood Gas Values Based on Storage Time Since Sampling: An Observational Study

2021 ◽  
Vol 11 (3) ◽  
pp. 517-521
Author(s):  
Alejandro Montero-Salinas ◽  
Marta Pérez-Ramos ◽  
Fernando Toba-Alonso ◽  
Leticia Quintana-DelRío ◽  
Jorge Suanzes-Hernández ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Observational Study ◽  
Partial Pressure ◽  
Group Analysis ◽  
Initial Time ◽  
Blood Gas ◽  
Initial Sample ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Prospective Longitudinal

Aim. To evaluate the influence of time on arterial blood gas values after artery puncture is performed. Method. Prospective longitudinal observational study carried out with gasometric samples from 86 patients, taken at different time intervals (0 (T0), 15 (T15), 30 (T30) and 60 (T60) min), from 21 October 2019 to 21 October 2020. The study variables were: partial pressure of carbon dioxide, bicarbonate, hematocrit, hemoglobin, potassium, lactic acid, pH, partial pressure of oxygen, saturation of oxygen, sodium and glucose. Results. The initial sample consisted of a total of 90 patients. Out of all the participants, four were discarded as they did not understand the purpose of the study; therefore, the total number of participants was 86, 51% of whom were men aged 72.59 on average (SD: 16.23). In the intra-group analysis, differences in PCO2, HCO3, hematocrit, Hb, K+ and and lactic acid were observed between the initial time of the test and the 15, 30 and 60 min intervals. In addition, changes in pH, pO2, SO2, Na and glucose were noted 30 min after the initial sample had been taken. Conclusions. The variation in the values, despite being significant, has no clinical relevance. Consequently, the recommendation continues to be the analysis of the GSA at the earliest point to ensure the highest reliability of the data and to provide the patient with the most appropriate treatment based on those results.

scholarly journals Symptoms of Posttraumatic Stress Disorder and Associated Risk Factors in Patients With Lung Cancer: A Longitudinal Observational Study

2018 ◽  
Vol 17 (4) ◽  
pp. 1195-1203 ◽  
Author(s):  
Jun Ni ◽  
Jian Feng ◽  
Linda Denehy ◽  
Yi Wu ◽  
Liqin Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Posttraumatic Stress Disorder ◽  
Observational Study ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Ptsd Symptoms ◽  
Newly Diagnosed ◽  
Cancer Symptoms ◽  
Longitudinal Observational Study ◽  
Prospective Longitudinal

Purpose. This study aimed to measure symptoms of posttraumatic stress disorder (PTSD) in Chinese patients following a new diagnosis of lung cancer. Secondary aims were to explore factors at diagnosis that may predict PTSD symptoms at 6 months. Methods. This was a prospective longitudinal observational study that included 93 patients with newly diagnosed lung cancer. PTSD symptomology was assessed using the PTSD Checklist Civilian Version (PCL-C) and health-related quality of life (HRQoL) was assessed with the European Organisation for the Research and Treatment of Cancer questionnaire. Measures were completed at diagnosis and 6 months. Results. No patient had PTSD at baseline or 6 months as measured by a score of ⩾50 in the PCL-C. However, at diagnosis, 44% of patients had “mild” symptoms of PTSD. At 6 months, 64% of patients had “mild” and 8% had “moderate” PTSD symptoms. PTSD symptom scores significantly worsened over 6 months (mean difference [95% CI] = 7.2 [5.4 to 9.0]). Six months after diagnosis, higher PTSD scores were seen in people who at diagnosis were younger ( P = .003), had a lower smoking pack history ( P = .012), displayed less sedentary behavior ( P < .005), or initially had worse cancer symptoms, including fatigue ( P = .001) and poorer HRQoL ( P = .004). Conclusions. Mild PTSD symptoms are common in patients with lung cancer 6 months after treatment; however, a full diagnosis of PTSD is uncommon. Screening for PTSD symptoms may be considered for at-risk patients with newly diagnosed lung cancer.

Effectiveness of Homoeopathy in Tinea corporis and Tinea cruris – A Prospective, Longitudinal Observational Study

2021 ◽  
Vol 10 (1) ◽  
pp. 618-627
Author(s):  
Yogeshwari Gupta ◽  
◽  
Sonia Tuteja ◽  
Ankita Acharya ◽  
Vikrant Tripathi ◽  
...  
Keyword(s):  
Observational Study ◽  
Fungal Infection ◽  
Clinical Symptom ◽  
Fungal Infections ◽  
Tinea Corporis ◽  
P Value ◽  
Tinea Cruris ◽  
Longitudinal Observational Study ◽  
Before And After ◽  
Prospective Longitudinal

Dermatophytoses refers to superficial fungal infection of keratinized tissues caused by keratinophilic dermatophytes. According to observations worldwide, dermatophytoses are the most common of the superficial fungal infections. It is common in tropics and may present in epidemic proportions in areas with high rates of humidity. This prospective, longitudinal, observational study was conducted at SKHMC, Jaipur for a period of 1 year (April 2018 to March 2019), aiming to ascertain the effectiveness of homoeopathic medicines in the treatment of Tinea corporis and Tinea cruris. In this study, 65 cases of Tinea Infection (33 cases of Tinea cruris & 32 cases of Tinea corporis) were treated with homoeopathic medicines prescribed on the basis of totality of the symptoms. Treatment outcomes were assessed using Clinical Symptom Score, designed for this study & approved by Institutional Ethical Committee. Out of 65 patients, 41 patients (63.1%) got improved; 19 patients (29.2%) were at status quo and 05 patients (07.7%) became worse. Maximum patients were found to be in the age group of 11-40 years (n=50; 76.9%). Males were observed to be affected more as compared to females. Paired t-test was conducted on the Clinical Symptom Scores obtained before and after treatment and the result showed that p value is < 0.05 & value of t (11.623) is greater than the tabulated value in t-table at df = 64 (1.997), which was statistically significant and which also concluded that homoeopathic medicines were effective in treating Tinea corporis and Tinea cruris. Keywords Homeopathy; Dermatophytoses; Fungal infection; Observational study

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