Primary Tumour Volume Delineation in Nasopharyngeal Carcinoma and Correlation with 1997 AJCC Tumour Stage Classification

2001 ◽  
Vol 30 (04) ◽  
pp. 231 ◽  
Author(s):  
Cheng-Chuan Chang ◽  
Mu-Kuan Chen ◽  
Mu-Tai Liu ◽  
Yung-Sung Wen ◽  
Hwa-Koon Wu ◽  
...  
2019 ◽  
Vol 7 (1) ◽  
pp. 24-29
Author(s):  
Dr. S.D. Shamsundar ◽  
◽  
Dr. Jagannath K.P. ◽  
Dr. Niveditha S. ◽  
Dr. K. Aradhana ◽  
...  

2004 ◽  
Vol 33 (05) ◽  
pp. 304 ◽  
Author(s):  
Mu-Kuan Chen ◽  
Hong-Shen Lee ◽  
Julia H. Chang ◽  
Cheng-Chuan Chang

2020 ◽  
Vol 152 ◽  
pp. S1078
Author(s):  
C. Piazzese ◽  
E. Evans ◽  
E. Spezi ◽  
J. Staffurth ◽  
S. Gwynne

Author(s):  
Tiffany Y. So ◽  
Qi-Yong Ai ◽  
Brigette B.Y. Ma ◽  
Ann D. King

<p class="abstract">Immune check point inhibitors have demonstrated promising efficacy in patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) in phase I and phase II trials. Early identification of treatment response is important in these patients. This report aimed to document the early intratreatment diffusion weighted magnetic resonance imaging (DW-MRI) findings in NPC patients following treatment with the programmed cell death-1 inhibitor, nivolumab. Two consecutive patients with histologically confirmed recurrent undifferentiated NPC treated with nivolumab were prospectively recruited. Nivolumab was administered at a dosage of 3 mg/kg intravenously every 2 weeks. Patients underwent magnetic resonance imaging examinations at baseline, and at 3 and 5 weeks after commencement of treatment. Intratreatment changes in tumour volume and apparent diffusion coefficient (ADC<sub>mean</sub>)were calculated. The endpoints were objective response by response evaluation criteria in solid tumors and survival. In patient 1, an intratreatment ADC increase at 5 weeks corresponded with anatomical tumour volume reduction and a better long-term survival outcome (progression free survival 1.3 years, overall survival 2.9 years). In patient 2, an intratreatment ADC decrease at 5 weeks corresponded to progressive disease and worse outcome (progression free survival 0.0 years, overall survival 0.9 years). Intratreatment ADC changes at 3 weeks were not associated with response outcome. These cases suggest that intratreatment changes in ADC at 5 weeks may potentially predict tumour response in patients treated with nivolumab. Dedicated studies are needed to clarify these findings and fully characterise patterns of treatment related ADC change.</p>


2013 ◽  
Vol 40 (6) ◽  
pp. 824-831 ◽  
Author(s):  
Ralph A. Bundschuh ◽  
Christina M. Wendl ◽  
Gregor Weirich ◽  
Mathias Eiber ◽  
Michael Souvatzoglou ◽  
...  

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