scholarly journals Effect of Age, Hours since Last Food, Time of Day, and Ketonuria on 1-Hour Glucose Tolerance

1972 ◽  
Vol 87 (7) ◽  
pp. 649 ◽  
Author(s):  
Nancy Phillips ◽  
Thomas Duffy
1986 ◽  
Vol 34 (4) ◽  
pp. 271-275 ◽  
Author(s):  
I. Zavaroni ◽  
E. Dall'Aglio ◽  
F. Bruschi ◽  
E. Bonora ◽  
O. Alpi ◽  
...  

1986 ◽  
Vol 251 (2) ◽  
pp. E196-E203
Author(s):  
A. Bonen ◽  
P. A. Clune ◽  
M. H. Tan

It has been postulated that the improved glucose tolerance provoked by chronic exercise is primarily attributable to increased insulin binding in skeletal muscle. Therefore, we investigated the effects of progressively increased training (6 wk) on insulin binding by five hindlimb skeletal muscles and in liver. In the trained animals serum insulin levels at rest were lower either in a fed (P less than 0.05) or fasted (P less than 0.05) state and after an oral glucose tolerance test (n = 8) (P less than 0.05). Twenty-four hours after the last exercise bout sections of the liver, soleus (S), plantaris (P), extensor digitorum longus (EDL), and red (RG) and white gastrocnemius (WG) muscles were pooled from four to six rats. From control animals, killed at the same time of day, muscles and liver were also obtained. Insulin binding to plasma membranes increased in S, P, and EDL (P less than 0.05) but not in WG (P = 0.07), RG (P greater than 0.1), or in liver (P greater than 0.1). There were insulin binding differences among muscles (P less than 0.05). Comparison of rank orders of insulin binding data with published glucose transport data for the same muscles revealed that these parameters do not correspond well. In conclusion, insulin binding to muscle is shown to be heterogeneous and training can increase insulin binding to selected muscles but not liver.


2012 ◽  
Vol 24 (6) ◽  
pp. 820-828 ◽  
Author(s):  
Torsten Eggert ◽  
Cornelia Sauter ◽  
Roland Popp ◽  
Josef Zeitlhofer ◽  
Heidi Danker-Hopfe ◽  
...  

1966 ◽  
Vol 59 (5) ◽  
pp. 1024-1025 ◽  
Author(s):  
D. D. Hardee ◽  
E. B. Mitchell ◽  
P. M. Huddleston
Keyword(s):  

1993 ◽  
Vol 265 (5) ◽  
pp. R1109-R1114 ◽  
Author(s):  
C. J. De Souza ◽  
A. H. Meier

The ability of timed daily increases in ambient temperature (from 22 +/- 1 degree C to 40 +/- 1 degree C for 2 h) to alter body fat stores, blood lipid levels, and insulin resistance were tested in male Holtzman rats. Of the six times of day tested only temperature pulses administered 16 h after light onset consistently decreased body weights, retroperitoneal fat stores, and plasma insulin levels. Subsequently, temperature pulses were administered either 0 (TP0) or 16 (TP16) h after light onset (light-dark 12:12 h). While no differences were observed between the TP0 group and the constant temperature (22 degrees C) controls, decreases in body weight gain, food consumption, retroperitoneal fat stores, and plasma concentrations of insulin, cholesterol, and triglycerides were consistently observed in the TP16 group. Although changes in plasma glucose during an oral glucose tolerance test were similar when the two treatment groups were compared with their respective controls, glucose tolerance was achieved with less insulin in the TP16 animals than in their respective controls. Insulin effectiveness was greater in the TP16 group as indicated by a decrease in plasma glucose, after insulin injection, that was of greater magnitude and longer duration than in controls. Hence, timed daily increases in ambient temperature may decrease obesity in part by decreasing plasma insulin levels apparently as a consequence of increased tissue sensitivity to insulin (greater glucose tolerance and less insulin intolerance). Because the treatment is effective only at a particular time of day the findings support a role for circadian neuroendocrine interactions in the regulation of these metabolic states.


1982 ◽  
Vol 30 (9) ◽  
pp. 562-567 ◽  
Author(s):  
MARK ROSENTHAL ◽  
LEONARD DOBERNE ◽  
MICHAEL GREENFIELD ◽  
ANDRES WIDSTROM ◽  
GERALD M. REAVEN

Diabetes ◽  
1976 ◽  
Vol 25 (10) ◽  
pp. 936-943 ◽  
Author(s):  
K. H. Mayer ◽  
J. Stamler ◽  
A. Dyer ◽  
N. Freinkel ◽  
R. Stamler ◽  
...  

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