Expression of Lauroyl-Acyl Carrier Protein Thioesterase in Brassica napus Seeds Induces Pathways for Both Fatty Acid Oxidation and Biosynthesis and Implies a Set Point for Triacylglycerol Accumulation

1998 ◽  
Vol 10 (4) ◽  
pp. 613 ◽  
Author(s):  
Victoria S. Eccleston ◽  
John B. Ohlrogge
Keyword(s):  
Fatty Acid ◽  
Brassica Napus ◽  
Fatty Acid Oxidation ◽  
Acyl Carrier Protein ◽  
Acid Oxidation ◽  
Carrier Protein ◽  
Set Point ◽  
Triacylglycerol Accumulation

scholarly journals Effects of milk diets containing beef tallow or coconut oil on the fatty acid metabolism of liver slices from preruminant calves

2000 ◽  
Vol 84 (3) ◽  
pp. 309-318 ◽  
Author(s):  
Benoît Graulet ◽  
Dominique Gruffat-Mouty ◽  
Denys Durand ◽  
Dominique Bauchart
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Beef Tallow ◽  
Neutral Lipids ◽  
Lipid Production ◽  
Coconut Oil ◽  
Acid Oxidation ◽  
Milk Diet ◽  
Liver Slices ◽  
Triacylglycerol Accumulation

Coconut oil (CO) induces a triacylglycerol infiltration in the hepatocytes of preruminant calves when given as the sole source of fat in the milk diet over a long-term period. Metabolic pathways potentially involved in this hepatic triacylglycerol accumulation were studied by in vitro methods on liver slices from preruminant Holstein × Friesian male calves fed a conventional milk diet containing CO (n 5) or beef tallow (BT, n 5) for 19 d. Liver slices were incubated for 12 h in the presence of 0·8 mM-[14C] oleate or -[14C] laurate added to the medium. Fatty acid oxidation was determined by measuring the production of CO2 (total oxidation) and acid-soluble products (partial oxidation). Production of CO2 was 1·7–3·6-fold lower (P 0·0490) and production of acid-soluble products tended to be lower (P = 0·0625) in liver slices of CO- than BT-fed calves. Fatty acid esterification as neutral lipids was 2·6– to 3·1–fold higher (P = 0·0088) in liver slices prepared from calves fed the CO diet compared with calves fed the BT diet. By contrast with what occurs in the liver of rats fed CO, the increase in neutral lipid production did not stimulate VLDL secretion by the hepatocytes of calves fed with CO, leading to a triacylglycerol accumulation in the cytosol. It could be explained by the reduction of fatty acid oxidation favouring esterification in the form of triacylglycerols, in association with a limited availability of triacylglycerols and/or apolipoprotein B for VLDL packaging and subsequent secretion.

Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

2019 ◽  
Author(s):  
Helena Urquijo ◽  
Emma N Panting ◽  
Roderick N Carter ◽  
Emma J Agnew ◽  
Caitlin S Wyrwoll ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Fetal Heart ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid
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