A New Family of Zinc Finger Proteins in Petunia: Structure, DNA Sequence Recognition, and Floral Organ-Specific Expression

1994 ◽  
Vol 6 (7) ◽  
pp. 947 ◽  
Author(s):  
Hiroshi Takatsuji ◽  
Norihisa Nakamura ◽  
Yukihisa Katsumoto
Keyword(s):  
Dna Sequence ◽  
Zinc Finger ◽  
Floral Organ ◽  
Zinc Finger Proteins ◽  
Specific Expression ◽  
New Family ◽  
Sequence Recognition ◽  
Organ Specific ◽  
Organ Specific Expression ◽  
Dna Sequence Recognition

scholarly journals Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain.

1993 ◽  
Vol 13 (4) ◽  
pp. 2366-2376 ◽  
Author(s):  
H Chen ◽  
Z Smit-McBride ◽  
S Lewis ◽  
M Sharif ◽  
M L Privalsky
Keyword(s):  
Amino Acids ◽  
Thyroid Hormone ◽  
Dna Sequence ◽  
Zinc Finger ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Nuclear Hormone Receptors ◽  
Zinc Finger Domain ◽  
Sequence Recognition ◽  
Dna Sequence Recognition

The erb A oncogene is a dominant negative allele of a thyroid hormone receptor gene and acts in the cancer cell by encoding a transcriptional repressor. We demonstrate here that the DNA sequence recognition properties of the oncogenic form of the erb A protein are significantly altered from those of the normal thyroid hormone receptors and more closely resemble those of the retinoic acid receptors; this alteration appears to play an important role in defining the targets of erb A action in neoplasia. Unexpectedly, the novel DNA recognition properties of erb A are encoded by an N-terminal region not previously implicated as playing this function in current models of receptor-DNA interaction. Two N-terminal erb A amino acids in particular, histidine 12 and cysteine 32, contribute to this phenomenon, acting in conjunction with amino acids in the zinc finger domain. The effects of the N-terminal domain can be observed at the level of both DNA binding and transcriptional modulation. Our results indicate that unanticipated determinants within the nuclear hormone receptors participate in DNA sequence recognition and may contribute to the differential target gene specificity displayed by different receptor forms.

Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain

1993 ◽  
Vol 13 (4) ◽  
pp. 2366-2376
Author(s):  
H Chen ◽  
Z Smit-McBride ◽  
S Lewis ◽  
M Sharif ◽  
M L Privalsky
Keyword(s):  
Amino Acids ◽  
Thyroid Hormone ◽  
Dna Sequence ◽  
Zinc Finger ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Nuclear Hormone Receptors ◽  
Zinc Finger Domain ◽  
Sequence Recognition ◽  
Dna Sequence Recognition

The erb A oncogene is a dominant negative allele of a thyroid hormone receptor gene and acts in the cancer cell by encoding a transcriptional repressor. We demonstrate here that the DNA sequence recognition properties of the oncogenic form of the erb A protein are significantly altered from those of the normal thyroid hormone receptors and more closely resemble those of the retinoic acid receptors; this alteration appears to play an important role in defining the targets of erb A action in neoplasia. Unexpectedly, the novel DNA recognition properties of erb A are encoded by an N-terminal region not previously implicated as playing this function in current models of receptor-DNA interaction. Two N-terminal erb A amino acids in particular, histidine 12 and cysteine 32, contribute to this phenomenon, acting in conjunction with amino acids in the zinc finger domain. The effects of the N-terminal domain can be observed at the level of both DNA binding and transcriptional modulation. Our results indicate that unanticipated determinants within the nuclear hormone receptors participate in DNA sequence recognition and may contribute to the differential target gene specificity displayed by different receptor forms.

Isolation, Characterization, and Organ-Specific Expression of Two Novel Human Zinc Finger Genes Related to theDrosophilaGenespalt

Genomics ◽  
1996 ◽  
Vol 38 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Jürgen Kohlhase ◽  
Reinhard Schuh ◽  
Gordon Dowe ◽  
Ronald P. Kühnlein ◽  
Herbert Jäckle ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Specific Expression ◽  
Zinc Finger Genes ◽  
Organ Specific ◽  
Organ Specific Expression

scholarly journals The structural basis of differential DNA sequence recognition by restriction–modification controller proteins

2012 ◽  
Vol 40 (20) ◽  
pp. 10532-10542 ◽  
Author(s):  
N. J. Ball ◽  
J. E. McGeehan ◽  
S. D. Streeter ◽  
S.-J. Thresh ◽  
G. G. Kneale
Keyword(s):  
Dna Sequence ◽  
Structural Basis ◽  
Sequence Recognition ◽  
Restriction Modification ◽  
Dna Sequence Recognition

Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression

2017 ◽  
Vol 139 (25) ◽  
pp. 8444-8447 ◽  
Author(s):  
Takuya Hidaka ◽  
Ganesh N. Pandian ◽  
Junichi Taniguchi ◽  
Tomohiro Nobeyama ◽  
Kaori Hashiya ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Sequence ◽  
Sequence Recognition ◽  
Mitochondrial Dna Sequence ◽  
Synthetic Ligand ◽  
Transcription Suppression ◽  
Dna Sequence Recognition

MuA Transposase Separates DNA Sequence Recognition from Catalysis†

Biochemistry ◽  
2003 ◽  
Vol 42 (49) ◽  
pp. 14633-14642 ◽  
Author(s):  
Ilana Goldhaber-Gordon ◽  
Michael H. Early ◽  
Tania A. Baker
Keyword(s):  
Dna Sequence ◽  
Sequence Recognition ◽  
Dna Sequence Recognition
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