Two Anthranilate Synthase Genes in Arabidopsis: Defense-Related Regulation of the Tryptophan Pathway

1992 ◽  
Vol 4 (6) ◽  
pp. 721
Author(s):  
Krishna K. Niyogi ◽  
Gerald R. Fink
Keyword(s):  
Anthranilate Synthase ◽  
Tryptophan Pathway ◽  
Arabidopsis Defense

scholarly journals Structure-Based in Vitro Engineering of the Anthranilate Synthase, a Metabolic Key Enzyme in the Plant Tryptophan Pathway

2005 ◽  
Vol 138 (4) ◽  
pp. 2260-2268 ◽  
Author(s):  
Takuya Kanno ◽  
Akira Komatsu ◽  
Koji Kasai ◽  
Joseph G. Dubouzet ◽  
Minako Sakurai ◽  
...  
Keyword(s):  
Anthranilate Synthase ◽  
Tryptophan Pathway ◽  
Key Enzyme

Anthranilate Synthase and Chorismate Mutase Activities in Stem Rust-Inoculated and Elicitor-Treated Resistant, Moderately Resistant, and Susceptible Near-Isogenic Wheat Lines

1995 ◽  
Vol 50 (1-2) ◽  
pp. 54-60 ◽  
Author(s):  
Claudia Bücker ◽  
Barbara Witte ◽  
Ursula Windmüller ◽  
Hans J. Grambow
Keyword(s):  
Stem Rust ◽  
Rust Fungus ◽  
Triticum Aestivum L ◽  
Enzyme Activation ◽  
Chorismate Mutase ◽  
Anthranilate Synthase ◽  
Resistance Response ◽  
Tryptophan Pathway ◽  
Wheat Lines ◽  
Moderately Resistant

Abstract Anthranilate synthase and chorismate mutase activities which control the flow of substrate from chorismate into the tryptophan pathway and into the phenylalanine/tyrosine pathway, respectively, were examined in three near isogenic wheat lines of Triticum aestivum L. (cv. Prelude Sr 5, highly resistant to stem rust infection; cv. Prelude Sr 24, moderately resistant; cv. Prelude srx, susceptible). The activities of both enzymes were found to increase in re­sponse to inoculation with the stem rust fungus Puccinia graminis f. sp. tritici or treatment with Pgt elicitor. Thus, both the tryptophan branch and the phenylalanine branch appear to contribute to the resistance response in wheat leaves. Only the cytosolic but not the plastidic fraction of the enzyme activities appears to be affected by fungal infection or elicitor treat­ment. Some differences with respect to degree and time dependency of enzyme activation were noticed between the three wheat lines following inoculation but not after treatment with the Pgt elicitor.

scholarly journals Anthranilate Synthase from Pseudomonas putida

1973 ◽  
Vol 248 (1) ◽  
pp. 151-161 ◽  
Author(s):  
Stephen W. Queener ◽  
Sherry F. Queener ◽  
J. Ralph Meeks ◽  
Irwin C. Gunsalus
Keyword(s):  
Pseudomonas Putida ◽  
Anthranilate Synthase

scholarly journals Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Junchao Huang ◽  
Jinghui Tong ◽  
Ping Zhang ◽  
Yanfang Zhou ◽  
Yimin Cui ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Cortical Thickness ◽  
Serum Levels ◽  
Healthy Controls ◽  
Tryptophan Pathway ◽  
Liquid Chromatography Tandem Mass ◽  
Therapeutic Development ◽  
Tryptophan Metabolites ◽  
Insight Into

AbstractA number of tryptophan metabolites known to be neuroactive have been examined for their potential associations with cognitive deficits in schizophrenia. Among these metabolites, kynurenic acid (KYNA), 5-hydroxyindole (5-HI), and quinolinic acid (QUIN) are documented in their diverse effects on α-7 nicotinic acetylcholine receptor (α7nAChR) and/or N-methyl-D-aspartate receptor (NMDAR), two of the receptor types thought to contribute to cognitive impairment in schizophrenia. In this study, serum levels of KYNA, 5-HI, and QUIN were measured in 195 patients with schizophrenia and in 70 healthy controls using liquid chromatography-tandem mass spectrometry; cognitive performance in MATRICS Consensus Cognitive Battery and cortical thickness measured by magnetic resonance imaging were obtained. Patients with schizophrenia had significantly lower serum KYNA (p < 0.001) and QUIN (p = 0.02) levels, and increased 5-HI/KYNA (p < 0.001) and QUIN/KYNA ratios (p < 0.001) compared with healthy controls. Multiple linear regression showed that working memory was positively correlated with serum 5-HI levels (t = 2.10, p = 0.04), but inversely correlated with KYNA concentrations (t = −2.01, p = 0.05) in patients. Patients with high 5-HI and low KYNA had better working memory than other subgroups (p = 0.01). Higher 5-HI levels were associated with thicker left lateral orbitofrontal cortex (t = 3.71, p = 2.94 × 10−4) in patients. The different effects of 5-HI and KYNA on working memory may appear consistent with their opposite receptor level mechanisms. Our findings appear to provide a new insight into the dynamic roles of tryptophan pathway metabolites on cognition, which may benefit novel therapeutic development that targets cognitive impairment in schizophrenia.

scholarly journals The fused anthranilate synthase from Streptomyces venezuelae functions as a monomer

2014 ◽  
Vol 400 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Meseret Ashenafi ◽  
Prasad T. Reddy ◽  
James F. Parsons ◽  
W. Malcolm Byrnes
Keyword(s):  
Anthranilate Synthase ◽  
Streptomyces Venezuelae

scholarly journals Metabolic Profiling of Tryptophan-overproducing Rice Calli that Express a Feedback-insensitive α Subunit of Anthranilate Synthase

2005 ◽  
Vol 46 (3) ◽  
pp. 514-521 ◽  
Author(s):  
Keiko Morino ◽  
Fumio Matsuda ◽  
Haruna Miyazawa ◽  
Akiko Sukegawa ◽  
Hisashi Miyagawa ◽  
...  
Keyword(s):  
Metabolic Profiling ◽  
Anthranilate Synthase ◽  
Α Subunit ◽  
Rice Calli
Sign in / Sign up

Export Citation Format

Share Document