Utilisations traditionnelles de Garcinia lucida et Garcinia kola (Clusiaceae) au Cameroun

2001 ◽  
Vol 71 (2) ◽  
pp. 747 ◽  
Author(s):  
N. M. Guedje ◽  
R. Fankap
Keyword(s):  
Garcinia Kola ◽  
Utilisations Traditionnelles

Modulatory Role of Kolaviron (KV), a Biflavonoid from Garcinia kola, in Sodium Arsenite-Induced Hepatotoxicity and Haematotoxicity in Rats

2016 ◽  
Vol 23 (1) ◽  
pp. 54
Author(s):  
Olalekan Samson Agboola ◽  
Ademola Adetokunbo Oyagbemi ◽  
Temidayo Olutayo Omobowale ◽  
Ebunoluwa Rachel Asenuga ◽  
Adebowale Bernard Saba
Keyword(s):  
Sodium Arsenite ◽  
Garcinia Kola

Kolaviron, a Biflavonoid Compound: Pharmacological activity and Therapeutic Efficacy

2021 ◽  
Vol 18 ◽  
Author(s):  
Damilare Rotimi ◽  
Jennifer Chidubem Amanze ◽  
Adebola Busola Ojo ◽  
Matthew Iyobhebhe ◽  
Tobiloba Christiana Elebiyo ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Treatment Options ◽  
Herbal Remedies ◽  
Clinical Settings ◽  
Garcinia Kola ◽  
Anti Cancer ◽  
The World ◽  
Health Promoting ◽  
Grown Plant ◽  
Viable Treatment

Abstract: The use of herbal remedies for medicinal purposes is becoming more popular around the world. As a result, plants have become viable treatment options for a variety of diseases. Garcinia kola (bitter kola) is a perennially grown plant in the Guttiferae family that has been evaluated and reported to have numerous health-promoting properties. Kolaviron is a biflavanoid and major phytochemical found in Garcinia kola that includes Garcinia Biflavanoid-1 (GB-1), kolaflavanone, and Garcinia Biflavanoid-2 (GB-2). It is obtained as a fraction extracted from Garcinia kola. Kolaviron's pharmacological properties include anti-inflammatory, anti-spasmodic, ameliorative, anti-asthmatic, anti-cancer, anti-malarial, hepatoprotective, antioxidant, anti-atherogenic, neuroprotective, anti-diabetic, and anti-amnesic properties. Kolaviron is recommended for use in clinical settings because it has been shown to have a high therapeutic efficacy in clinical trials. The purpose of this review is to assess the therapeutic efficacy of kolaviron.

Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

2021 ◽  
Vol 18 ◽  
Author(s):  
Kehinde S. Olaniyi ◽  
Isaiah W. Sabinari ◽  
Adesola A. Oniyide ◽  
Nifesimi T. Akinnagbe ◽  
Toluwani B. Agunbiade ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Wistar Rats ◽  
Concomitant Administration ◽  
Energy Regulation ◽  
Aqueous Extracts ◽  
Garcinia Kola ◽  
Or Management ◽  
Male Wistar Rats ◽  
Susceptible Populations ◽  
Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

Gakolanone: a new benzophenone derivative from Garcinia kola Heckel stem-bark

2018 ◽  
Vol 34 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Seide M. Akoro ◽  
Olapeju O. Aiyelaagbe ◽  
Patricia A. Onocha ◽  
James B. Gloer
Keyword(s):  
Stem Bark ◽  
Garcinia Kola ◽  
Garcinia Kola Heckel
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