Enzymatic Catalysis in Biological Energy Coupling

1960 ◽  
Vol 2 ◽  
pp. 503 ◽  
Author(s):  
I. C. Gunsalus
Keyword(s):  
Enzymatic Catalysis ◽  
Energy Coupling

RF energy coupling to high-pressure optically pumped nonequilibrium plasmas

2001 ◽  
Author(s):  
Peter Palm ◽  
Elke Plonjes ◽  
Wonchul Lee ◽  
Kraig Frederickson ◽  
Walter Lempert ◽  
...  
Keyword(s):  
High Pressure ◽  
Energy Coupling ◽  
Optically Pumped ◽  
Nonequilibrium Plasmas ◽  
Rf Energy

Matrix metalloproteinases: structure, functions and genetic polymorphism

2017 ◽  
pp. 14-23
Author(s):  
А.С. Шадрина ◽  
И.В. Терешкина ◽  
Я.З. Плиева ◽  
Д.Н. Кушлинский ◽  
Д.О. Уткин ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Matrix Metalloproteinases ◽  
Active Center ◽  
Human Body ◽  
Enzymatic Catalysis ◽  
Structure Functions ◽  
Zinc Ion ◽  
Etiological Factors ◽  
Mmp Genes

Матриксные металлопротеиназы (ММП) - ферменты класса гидролаз, осуществляющие ферментативный катализ с помощью связанного в активном центре иона цинка. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В данном обзоре рассмотрена классификация ММП человека, особенности их структуры и регуляции, а также роль в физиологических и патологических процессах в организме человека. Приведен перечень наиболее изученных на настоящий момент полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований. Matrix metalloproteinases (MMPs) are enzymes of the hydrolase class that carry out enzymatic catalysis with the help of a zinc ion bound in the active center. MMP functions are diverse, and a disturbance in the balance of their activity may be one of the etiological factors of various diseases. In this review, the classification of human MMP, the features of their structure and regulation, as well as the role in physiological and pathological processes in the human body are considered. A list of the most studied polymorphic versions of MMP genes has been given, their functional effects have been described, and the results of associative studies have been presented.

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Energy Coupling ◽  
Coupling Factor ◽  
Design Synthesis ◽  
Screening Design ◽  
Starting Point ◽  
Wide Range ◽  
Vitamin Uptake

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>

scholarly journals Energy Coupling in Membrane Vesicles of Escherichia coli

1974 ◽  
Vol 249 (9) ◽  
pp. 2939-2945
Author(s):  
Hajime Hirata ◽  
Karlheinz Altendorf ◽  
Franklin M. Harold
Keyword(s):  
Escherichia Coli ◽  
Membrane Vesicles ◽  
Energy Coupling

The Role of Hydrophobicity in Supramolecular Polymer/Surfactant Catalysts: An Understandable Model for Enzymatic Catalysis

2020 ◽  
Author(s):  
Paulo F.A. Costa ◽  
Rafael de Abreu ◽  
Andressa B. Fontana ◽  
Haidi D. Fiedler ◽  
Anthony J. Kirby ◽  
...  
Keyword(s):  
Enzymatic Catalysis ◽  
Supramolecular Polymer ◽  
Polymer Surfactant

scholarly journals Multi-Device Piezoelectric Direct Discharge for Large Area Plasma Treatment

Plasma ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 281-293
Author(s):  
Dariusz Korzec ◽  
Florian Hoppenthaler ◽  
Anatoly Shestakov ◽  
Dominik Burger ◽  
Andrej Shapiro ◽  
...  
Keyword(s):  
Atmospheric Pressure Plasma ◽  
Energy Coupling ◽  
Limiting Factors ◽  
Dielectric Barrier Discharges ◽  
Large Area ◽  
Image Recording ◽  
Cold Atmospheric Pressure Plasma ◽  
Planar Substrates ◽  
Barrier Discharges ◽  
Direct Discharge

The piezoelectric cold plasma generators (PCPG) allow for production of the piezoelectric direct discharge (PDD), which is a kind of cold atmospheric pressure plasma (APP). The subjects of this study are different arrays of PCPGs for large-area treatment of planar substrates. Two limiting factors are crucial for design of such arrays: (i) the parasitic coupling between PCPGs resulting in minimum allowed distance between devices, and (ii) the homogeneity of large area treatment, requiring an overlap of the activation zones resulting from each PCPG. The first limitation is investigated by the use of electric measurements. The minimum distance for operation of 4 cm between two PCPGs is determined by measurement of the energy coupling from an active PCPG to a passive one. The capacitive probe is used to evaluate the interference between signals generated by two neighboring PCPGs. The second limitation is examined by activation image recording (AIR). Two application examples illustrate the compromising these two limiting factors: the treatment of large area planar substrates by PCPG array, and the pretreatment of silicon wafers with an array of PCPG driven dielectric barrier discharges (DBD).

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