The Compound Factor of the 10 B(n,α) 7 Li Reaction from Borocaptate Sodium and the Relative Biological Effectiveness of Recoil Protons for Induction of Brain Damage in Boron Neutron Capture Therapy

1998 ◽  
Vol 149 (4) ◽  
pp. 378 ◽  
Author(s):  
Detlef Gabel ◽  
Katharina H. I. Philipp ◽  
Floyd J. Wheeler ◽  
René Huiskamp ◽  
Rene Huiskamp
Keyword(s):  
Brain Damage ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Biological Effectiveness

scholarly journals Thermal neutron Relative Biological Effectiveness factors for Boron Neutron Capture Therapy from In Vitro Irradiations

2020 ◽  
Author(s):  
María Pedrosa-Rivera ◽  
Javier Praena ◽  
Ignacio Porras ◽  
Manuel Pedro Sabariego ◽  
Ulli Köster ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Thermal Neutron ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Tumor Cell Lines ◽  
Boron Neutron Capture ◽  
Effectiveness Factors ◽  
Biological Effectiveness

The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. Present values have been obtained using mixed beams consisting of both neutrons and photons of various energies. A common weighting factor has been used for both thermal and fast neutron doses, although such an approach has been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam has been used to determine thermal neutron relative biological effectiveness factors. Different tumor cell lines, corresponding to glioblastoma, melanoma, and head and neck squamous cell carcinoma, and non-tumor cell lines (lung fibroblast and embryonic kidney) have been irradiated using an experimental arrangement designed to minimise neutron-induced secondary gamma radiation. Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference data for comparison with that from neutron irradiation. Survival and proliferation were studied after irradiation, yielding the Relative Biological Effectiveness corresponding to the damage of thermal neutrons for the different tissue types.

scholarly journals Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2302
Author(s):  
Seth W. Streitmatter ◽  
Robert D. Stewart ◽  
Gregory Moffitt ◽  
Tatjana Jevremovic
Keyword(s):  
Cell Survival ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Mechanistic Modeling ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Radiobiological Model ◽  
Biological Effectiveness ◽  
Her 2

Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels. In this paper, we present a computational, multiscale system of models to better assess the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) of several neutron sources as applied to BNCT using boronophenylalanine (BPA) and a potential monoclonal antibody (mAb) that targets HER-2-positive cells with Trastuzumab. The multiscale model is tested against published in vitro and in vivo measurements of cell survival with and without boron. The combined dosimetric and radiobiological model includes an analytical formulation that accounts for the type of neutron source, the tissue- or cancer-specific dose–response characteristics, and the microdistribution of boron. Tests of the model against results from published experiments with and without boron show good agreement between modeled and experimentally determined cell survival for neutrons alone and in combination with boron. The system of models developed in this work is potentially useful as an aid for the optimization and individualization of BNCT for HER-2-positive cancers, as well as other cancers, that can be targeted with mAb or a conventional BPA compound.

scholarly journals Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2144
Author(s):  
María Pedrosa-Rivera ◽  
Javier Praena ◽  
Ignacio Porras ◽  
Manuel P. Sabariego ◽  
Ulli Köster ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Cell Lines ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Effectiveness Factors ◽  
Biological Effectiveness

The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for both thermal and fast neutron doses, although such an approach has been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam has been used to determine thermal neutron relative biological effectiveness factors. Different cancer cell lines, which correspond to glioblastoma, melanoma, and head and neck squamous cell carcinoma, and non-tumor cell lines (lung fibroblast and embryonic kidney), have been irradiated while using an experimental arrangement designed to minimize neutron-induced secondary gamma radiation. Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference data for comparison with that from neutron irradiation. The survival and proliferation were studied after irradiation, yielding the Relative Biological Effectiveness that corresponds to the damage of thermal neutrons for the different tissue types.

scholarly journals Implications of radiation microdosimetry for accelerator-based boron neutron capture therapy: a radiobiological perspective

2020 ◽  
Vol 93 (1111) ◽  
pp. 20200311
Author(s):  
Hisanori Fukunaga ◽  
Yusuke Matsuya ◽  
Koichi Tokuuye ◽  
Motoko Omura
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Therapeutic Potential ◽  
Biological Effects ◽  
Point Of View ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Medical Institutions ◽  
Biological Effectiveness ◽  
Underlying Mechanisms

Boron neutron capture therapy (BNCT) has great potential to selectively destroy cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly used in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of radiation microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of compound biological effectiveness. Radiobiological perspectives provide insight into the effectiveness of BNCT in creating a synergy effect in the field of clinical oncology.

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