Measurements of Relative Biological Effectiveness of the 70 MeV Proton Beam at TRIUMF Using Chinese Hamster V79 Cells and the High-Precision Cell Sorter Assay

1996 ◽  
Vol 146 (2) ◽  
pp. 159 ◽  
Author(s):  
B. G. Wouters ◽  
G. K. Y. Lam ◽  
U. Oelfke ◽  
K. Gardey ◽  
R. E. Durand ◽  
...  
Keyword(s):  
Proton Beam ◽  
High Precision ◽  
Relative Biological Effectiveness ◽  
Chinese Hamster ◽  
V79 Cells ◽  
Cell Sorter ◽  
Chinese Hamster V79 Cells ◽  
Biological Effectiveness

scholarly journals Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro

2016 ◽  
Vol 57 (3) ◽  
pp. 307-311 ◽  
Author(s):  
Kenichiro Maeda ◽  
Hironobu Yasui ◽  
Taeko Matsuura ◽  
Tohru Yamamori ◽  
Motofumi Suzuki ◽  
...  
Keyword(s):  
Proton Beam ◽  
Relative Biological Effectiveness ◽  
Chinese Hamster ◽  
University Hospital ◽  
Quadratic Model ◽  
Linear Quadratic ◽  
Proton Beams ◽  
Spot Scanning ◽  
Biological Effectiveness ◽  
Passive Scattering

Abstract Variations in relative biological effectiveness (RBE) from a fixed value of 1.1 are critical in proton beam therapy. To date, studies estimating RBE at multiple positions relative to the spread-out Bragg peak (SOBP) have been predominantly performed using passive scattering methods, and limited data are available for spot-scanning beams. Thus, to investigate the RBE of spot-scanning beams, Chinese hamster fibroblast V79 cells were irradiated using the beam line at the Hokkaido University Hospital Proton Therapy Center. Cells were placed at six different depths, including the entrance of the proton beam and the proximal and distal part of the SOBP. Surviving cell fractions were analyzed using colony formation assay, and cell survival curves were obtained by the curve fitted using a linear–quadratic model. RBE 10 and RBE 37 were 1.15 and 1.21 at the center of the SOBP, respectively. In contrast, the distal region showed higher RBE values (1.50 for RBE 10 and 1.85 for RBE 37 ). These results are in line with those of previous studies conducted using passive scattering proton beams. Taken together, these data strongly suggest that variations in RBE should be considered during treatment planning for spot-scanning beams as well as for passive scattering proton beams.

Genotoxicity of 1-nitronaphthalene in Chinese hamster V79 cells

1991 ◽  
Vol 259 (1) ◽  
pp. 111-121 ◽  
Author(s):  
B.G. Boyes ◽  
C.G. Rogers ◽  
R. Stapley
Keyword(s):  
Chinese Hamster ◽  
V79 Cells ◽  
Chinese Hamster V79 Cells

Survival and DNA Damage in Chinese Hamster V79 Cells Exposed to Alpha Particles Emitted by DNA-Incorporated Astatine-211

1998 ◽  
Vol 150 (3) ◽  
pp. 263 ◽  
Author(s):  
Malgorzata A. Walicka ◽  
G. Vaidyanathan ◽  
Michael R. Zalutsky ◽  
S. James Adelstein ◽  
Amin I. Kassis
Keyword(s):  
Dna Damage ◽  
Chinese Hamster ◽  
Alpha Particles ◽  
V79 Cells ◽  
Chinese Hamster V79 Cells
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