Genomic Instability in Chinese Hamster Cells after Exposure to X Rays or Alpha Particles of Different Mean Linear Energy Transfer

1997 ◽  
Vol 147 (1) ◽  
pp. 22 ◽  
Author(s):  
L. Manti ◽  
M. Jamali ◽  
K. M. Prise ◽  
B. D. Michael ◽  
K-R. Trott
Keyword(s):  
Energy Transfer ◽  
Genomic Instability ◽  
Linear Energy Transfer ◽  
Chinese Hamster ◽  
Alpha Particles ◽  
X Rays ◽  
Chinese Hamster Cells

scholarly journals Survival Curves and Age Response Functions for Chinese Hamster Cells Exposed to X-Rays or High LET Alpha-Particles

1972 ◽  
Vol 52 (1) ◽  
pp. 88 ◽  
Author(s):  
E. J. Hall ◽  
W. Gross ◽  
R. F. Dvorak ◽  
A. M. Kellerer ◽  
H. H. Rossi
Keyword(s):  
Chinese Hamster ◽  
Alpha Particles ◽  
X Rays ◽  
Response Functions ◽  
Survival Curves ◽  
Chinese Hamster Cells ◽  
High Let

scholarly journals Equivalency of the quality of sublethal lesions after photons and high-linear energy transfer ion beams

2017 ◽  
Vol 58 (6) ◽  
pp. 803-808 ◽  
Author(s):  
Yoshiya Furusawa ◽  
Mizuho Nakano-Aoki ◽  
Yoshitaka Matsumoto ◽  
Ryoichi Hirayama ◽  
Alisa Kobayashi ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Ion Beam ◽  
Chinese Hamster ◽  
Heavy Ion ◽  
Ion Beams ◽  
X Rays ◽  
High Let ◽  
High Linear Energy Transfer

Abstract The quality of the sublethal damage (SLD) after irradiation with high–linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Accelerator in the Chiba facility. The cells were kept at room temperature and then exposed to a secondary test dose of X-rays. Based on the repair kinetics study, the surviving fraction of cells quickly increased with the repair time, and reached a plateau in 2–3 h, even when cells had received priming monoenergetic high-LET beams or spread-out Bragg peak beams as well as X-ray irradiation. The shapes of the cell survival curves from the secondary test X-rays, after repair of the damage caused by the high-LET irradiation, were similar to those obtained from cells exposed to primary X-rays only. Complete SLD repairs were observed, even when the LET of the primary ion beams was very high. These results suggest that the SLD caused by high-LET irradiation was repaired well, and likewise, the damage caused by the X-rays. In cells where the ion beam had made a direct hit in the core region in an ion track, lethal damage to the domain was produced, resulting in cell death. On the other hand, in domains that had received a glancing hit in the low-LET penumbra region, the SLD produced was completely repaired.

scholarly journals The effect of low LET (Linear Energy Transfer) ionizing radiation to catalase activity of wistar’s submandibular gland

2016 ◽  
Vol 1 (3) ◽  
pp. 145
Author(s):  
Nevy T. Putri ◽  
Sarianoferni Sarianoferni ◽  
Endah Wahjuningsih
Keyword(s):  
Energy Transfer ◽  
Ionizing Radiation ◽  
Submandibular Gland ◽  
Rattus Norvegicus ◽  
Catalase Activity ◽  
Linear Energy Transfer ◽  
Submandibular Salivary Gland ◽  
X Rays ◽  
X Ray ◽  
Bonferroni Test

Intraoral periapical radiograph examination is the additional examination which is the most widely used in Dentistry. This radiograph examination using an x-ray ionizing radiation with low LET (Linear Energy Transfer), and may affect submandibular salivary gland. Ionizing radiation exposure can cause damage by inducing a series of changes at the molecular and cellular level. This study aimed to prove the effects of x-ray ionizing radiation with low LET towards the catalase activity of Rattus norvegicus strain Wistar’s submandibular gland. The subjects were 28 male Wistar rats and divided into 4 groups (n=7). Three groups were exposed 4, 8 and 14 times to radiation with 0.002 µSv for each exposure. The catalase activity of each rat was examined by a spectrophotometer. Data were analyzed using one-way ANOVA followed by Bonferroni test. The results showed the average of catalase activity on Wistar rat’s submandibular gland, respectively for: 0.150±0.0895 (KK), 0.1405±0.0607 (K1), 0.1228±0.0290 (K2), 0.1227±0.0556 (K3). Data showed significant differences of catalase activity between test groups, but showed not significant differences of catalase activity between each groups of Rattus norvegicus strain Wistar’s submandibular gland. In this study concluded decreased catalase activity of Rattus norvegicus strain Wistar’s submandibular gland resulting from x-rays ionizing radiation by 4 times, 8 times and 14 times exposures.

scholarly journals Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

DNA Repair ◽  
2008 ◽  
Vol 7 (3) ◽  
pp. 515-522 ◽  
Author(s):  
Hatsumi Nagasawa ◽  
Paul F. Wilson ◽  
David J. Chen ◽  
Larry H. Thompson ◽  
Joel S. Bedford ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Sister Chromatid ◽  
Chinese Hamster ◽  
Sister Chromatid Exchanges ◽  
Alpha Particles ◽  
Low Doses ◽  
Chinese Hamster Cells ◽  
Chromatid Exchanges

In VitroEvaluation of Combined Temozolomide and Radiotherapy Using X Rays and High-Linear Energy Transfer Radiation for Glioblastoma

2012 ◽  
Vol 177 (5) ◽  
pp. 651-662 ◽  
Author(s):  
Lara Barazzuol ◽  
Raj Jena ◽  
Neil G. Burnet ◽  
Jonathan C. G. Jeynes ◽  
Michael J. Merchant ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
X Rays ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer
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