Breast Cancer Mortality between 1950 and 1987 after Exposure to Fractionated Moderate-Dose-Rate Ionizing Radiation in the Canadian Fluoroscopy Cohort Study and a Comparison with Breast Cancer Mortality in the Atomic Bomb Survivors Study

1996 ◽  
Vol 145 (6) ◽  
pp. 694 ◽  
Author(s):  
Geoffrey R. Howe ◽  
John McLaughlin
2017 ◽  
Vol 116 (6) ◽  
pp. 828-839 ◽  
Author(s):  
Stephen Morrell ◽  
Richard Taylor ◽  
David Roder ◽  
Bridget Robson ◽  
Marli Gregory ◽  
...  

2016 ◽  
Vol 34 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Anne Gulbech Ording ◽  
Uffe Heide-Jørgensen ◽  
Christian Fynbo Christiansen ◽  
Mette Nørgaard ◽  
John Acquavella ◽  
...  

2018 ◽  
Vol 144 (4) ◽  
pp. 697-706 ◽  
Author(s):  
Mette H. Møller ◽  
Mette Lise Lousdal ◽  
Ivar S. Kristiansen ◽  
Henrik Støvring

2011 ◽  
Vol 29 (4) ◽  
pp. 428-434 ◽  
Author(s):  
Masako Iwanaga ◽  
Wan-Ling Hsu ◽  
Midori Soda ◽  
Yumi Takasaki ◽  
Masayuki Tawara ◽  
...  

Purpose The risk of myelodysplastic syndromes (MDS) has not been fully investigated among people exposed to ionizing radiation. We investigate MDS risk and radiation dose-response in Japanese atomic bomb survivors. Patients and Methods We conducted a retrospective cohort study by using two databases of Nagasaki atomic bomb survivors: 64,026 people with known exposure distance in the database of Nagasaki University Atomic-Bomb Disease Institute (ABDI) and 22,245 people with estimated radiation dose in the Radiation Effects Research Foundation Life Span Study (LSS). Patients with MDS diagnosed from 1985 to 2004 were identified by record linkage between the cohorts and the Nagasaki Prefecture Cancer Registry. Cox and Poisson regression models were used to estimate relationships between exposure distance or dose and MDS risk. Results There were 151 patients with MDS in the ABDI cohort and 47 patients with MDS in the LSS cohort. MDS rate increased inversely with exposure distance, with an excess relative risk (ERR) decay per km of 1.2 (95% CI, 0.4 to 3.0; P < .001) for ABDI. MDS risk also showed a significant linear response to exposure dose level (P < .001) with an ERR per Gy of 4.3 (95% CI, 1.6 to 9.5; P < .001). After adjustment for sex, attained age, and birth year, the MDS risk was significantly greater in those exposed when young. Conclusion A significant linear radiation dose-response for MDS exists in atomic bomb survivors 40 to 60 years after radiation exposure. Clinicians should perform careful long-term follow-up of irradiated people to detect MDS as early as possible.


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