WR-1065 and Radioprotection of Vascular Endothelial Cells. I. Cell Proliferation, DNA Synthesis and Damage

1996 ◽  
Vol 145 (2) ◽  
pp. 210 ◽  
Author(s):  
D. B. Rubin ◽  
E. A. Drab ◽  
H. J. Kang ◽  
F. E. Baumann ◽  
E. R. Blazek
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Dna Synthesis ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation

2000 ◽  
Vol 113 (17) ◽  
pp. 3117-3123 ◽  
Author(s):  
C. Wadham ◽  
J.R. Gamble ◽  
M.A. Vadas ◽  
Y. Khew-Goodall
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Nuclear Protein ◽  
Vascular Endothelial Cells ◽  
Tyrosine Phosphatase ◽  
Subcellular Localisation ◽  
Vascular Endothelial ◽  
Proliferating Cells ◽  
Wound Edge

Pez is a non-transmembrane tyrosine phosphatase with homology to the FERM (4.1, ezrin, radixin, moesin) family of proteins. The subcellular localisation of Pez in endothelial cells was found to be regulated by cell density and serum concentration. In confluent monolayers Pez was cytoplasmic, but in cells cultured at low density Pez was nuclear, suggesting that it is a nuclear protein in proliferating cells. This notion is supported by the loss of nuclear Pez when cells are serum-starved to induce quiescence, and the rapid return of Pez to the nucleus upon refeeding with serum to induce proliferation. Vascular endothelial cells normally exist as a quiescent confluent monolayer but become proliferative during angiogenesis or upon vascular injury. Using a ‘wound’ assay to mimic these events in vitro, Pez was found to be nuclear in the cells that had migrated and were proliferative at the ‘wound’ edge. TGFbeta, which inhibits cell proliferation but not migration, inhibited the translocation of Pez to the nucleus in the cells at the ‘wound’ edge, further strengthening the argument that Pez plays a role in the nucleus during cell proliferation. Together, the data presented indicate that Pez is a nuclear tyrosine phosphatase that may play a role in cell proliferation.

Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo

2001 ◽  
Vol 173 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Itaru Nishizuka ◽  
Yasushi Ichikawa ◽  
Takashi Ishikawa ◽  
Masako Kamiyama ◽  
Satoshi Hasegawa ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Dna Synthesis ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Engagement of CD44 modulates cyclooxygenase induction, VEGF generation, and cell proliferation in human vascular endothelial cells

2005 ◽  
Vol 19 (3) ◽  
pp. 1-17 ◽  
Author(s):  
Joseph F. Murphy ◽  
Frances Lennon ◽  
Christopher Steele ◽  
Dermot Kelleher ◽  
Desmond Fitzgerald ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals TMIC-39. CROSSTALK WITH VASCULAR ENDOTHELIAL CELLS DRIVES PRONEURAL GLIOMA STEM CELL PROLIFERATION THROUGH THE UPREGULATED NTF3/TrkB PATHWAY

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi251-vi251
Author(s):  
Suojun Zhang ◽  
Hai Yu ◽  
Soniya Bastola ◽  
Mutsuko Minata ◽  
Heba Allah Alsheikh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Stem Cell ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Glioma Stem Cell ◽  
Stem Cell Proliferation

Glucose Reduces PDGF Production and Cell Proliferation of Cultured Vascular Endothelial Cells

1991 ◽  
Vol 23 (06) ◽  
pp. 274-277 ◽  
Author(s):  
F. Umeda ◽  
T. Yamauchi ◽  
N. Nakashima ◽  
H. Ono ◽  
H. Nawata ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I

FEBS Letters ◽  
1997 ◽  
Vol 415 (3) ◽  
pp. 321-324 ◽  
Author(s):  
Yuji Hiraki ◽  
Takaharu Kono ◽  
Mutsumi Sato ◽  
Chisa Shukunami ◽  
Jun Kondo
Keyword(s):  
Endothelial Cells ◽  
Dna Synthesis ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Inhibition Of Dna Synthesis ◽  
Tube Morphogenesis
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