A Transient Mathematical Model of Oxygen Depletion during Photodynamic Therapy

1995 ◽  
Vol 142 (2) ◽  
pp. 221 ◽  
Author(s):  
Jeffery P. Henning ◽  
Ronald L. Fournier ◽  
James A. Hampton
Keyword(s):  
Mathematical Model ◽  
Photodynamic Therapy ◽  
Oxygen Depletion

A comprehensive mathematical model of microscopic dose deposition in photodynamic therapy

2006 ◽  
Vol 34 (1) ◽  
pp. 282-293 ◽  
Author(s):  
Ken Kang-Hsin Wang ◽  
Soumya Mitra ◽  
Thomas H. Foster
Keyword(s):  
Mathematical Model ◽  
Photodynamic Therapy ◽  
Dose Deposition

Oxygen Depletion during and after mTHPC-Mediated Photodynamic Therapy in RIF1 and H-MESO1 Tumors

2003 ◽  
Vol 159 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Hugo Schouwink ◽  
Hugo Oppelaar ◽  
Marjan Ruevekamp ◽  
Martin van der Valk ◽  
Guus Hart ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Depletion

scholarly journals Al-enabled, implantable, multichannel wireless telemetry for photodynamic therapy

2021 ◽  
Author(s):  
Woo Seok Kim ◽  
M. Ibrahim Khot ◽  
Hyun-Myung Woo ◽  
Dong-Hyun Baek ◽  
Sungcheol Hong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Depletion ◽  
Clinical Settings ◽  
Light Sources ◽  
Spatiotemporal Resolution ◽  
Light Delivery ◽  
Wireless Telemetry ◽  
Multi Wavelength ◽  
Thermal Light ◽  
Fundamental Research

Abstract Photodynamic therapy (PDT) is an alternative method for treating cancers, and its outcomes are highly dependent on light delivery to tumor cells to activate a photosensitizer. Existing approaches paired with advances in wireless technologies enable remote delivery of light to tumors but suffer from poor spatiotemporal resolution due to inabilities to minimize oxygen depletion in a tumor. Here, we introduce AI-informed low-power wireless telemetry with an integrated thermal/light simulation platform that bypasses all constraints above. The simulator leads to the optimized combination of wavelengths and light sources, and AI-assisted wireless telemetry uses the parameters from the simulator to enable adequate illumination of tumors through high-throughput (< 20 mice) and multi-wavelength operation. They establish a range of guidelines for effective PDT regimen design. Hypericin and Foscan mediated PDT demonstrated substantial suppression of tumor growth, suggesting that the proposed platform provides the potential for widespread use in fundamental research and/or clinical settings.

Low-temperature annealing of YBa2Cu3O7-x

1992 ◽  
Vol 50 (1) ◽  
pp. 88-89
Author(s):  
R.L. Sabatini ◽  
Yimei Zhu ◽  
Masaki Suenaga ◽  
A.R. Moodenbaugh
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Low Temperature ◽  
Oxygen Diffusion ◽  
Diffusion Rate ◽  
Oxygen Depletion ◽  
Low Temperature Annealing ◽  
Transmission Electron ◽  
Microstructural Effects ◽  
Oxygen Diffusion Rate

Low temperature annealing (<400°C) of YBa2Cu3O7x in a ozone containing oxygen atmosphere is sometimes carried out to oxygenate oxygen deficient thin films. Also, this technique can be used to fully oxygenate thinned TEM specimens when oxygen depletion in thin regions is suspected. However, the effects on the microstructure nor the extent of oxygenation of specimens has not been documented for specimens exposed to an ozone atmosphere. A particular concern is the fact that the ozone gas is so reactive and the oxygen diffusion rate at these temperatures is so slow that it may damage the specimen by an over-reaction. Thus we report here the results of an investigation on the microstructural effects of exposing a thinned YBa2Cu3O7-x specimen in an ozone atmosphere using transmission electron microscopy and energy loss spectroscopy techniques.

Sign in / Sign up

Export Citation Format

Share Document