The Genetic Basis of Cellular Recovery from Radiation Damage: Response of the Radiosensitive irs Lines to Low-Dose-Rate Irradiation

1995 ◽  
Vol 144 (3) ◽  
pp. 294 ◽  
Author(s):  
John Thacker ◽  
R. E. Wilkinson
Keyword(s):  
Dose Rate ◽  
Radiation Damage ◽  
Genetic Basis ◽  
Low Dose ◽  
Low Dose Rate ◽  
Damage Response

scholarly journals DNA damage response in peripheral mouse blood leukocytes in vivo after variable, low-dose rate exposure

2020 ◽  
Vol 59 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Qi Wang ◽  
Monica Pujol-Canadell ◽  
Maria Taveras ◽  
Guy Garty ◽  
Jay Perrier ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dose Rate ◽  
Dna Damage Response ◽  
Low Dose ◽  
Mouse Blood ◽  
Blood Leukocytes ◽  
Low Dose Rate ◽  
Damage Response

scholarly journals DNA damage response in peripheral mouse blood leukocytesin vivoafter variable, low-dose rate exposure

2019 ◽  
Author(s):  
Qi Wang ◽  
Monica C. Pujol ◽  
Guy Garty ◽  
Maria Taveras ◽  
Jay Perrier ◽  
...  
Keyword(s):  
Dna Damage ◽  
Total Dose ◽  
Dose Rate ◽  
Dna Damage Response ◽  
Low Dose ◽  
Reactor Accident ◽  
Roc Curve Analysis ◽  
Low Dose Rate ◽  
Damage Response ◽  
Accumulated Dose

AbstractEnvironmental contamination and ingestion of the radionuclide Cesium-137 (137Cs) is a large concern in fallout from a nuclear reactor accident and improvised nuclear device and highlights the need to develop biological assays for low dose rate, internal emitter radiation. To mimic low dose rates attributable to fallout, we have developed a VAriable Dose-rate External137Cs irradiatoR (VADER), which can provide arbitrarily varying and progressive low dose rate irradiations in the range of 1.2 to 0.1 Gy/day, while circumventing the complexities of dealing with radioactively-contaminated biomaterials. We investigated the kinetics of mouse peripheral leukocytes DNA damage response in vivo after variable, low-dose rate137Cs exposure. C57BL/6 mice were placed in the VADER over 7 days with total accumulated dose up to 2.7 Gy. Peripheral blood response including the leukocytes depletion, apoptosis signal protein p53 and DNA repair biomarker γ-H2AX were measured. The results illustrated that blood leukocyte count had significantly dropped by days 7. P53 levels peaked at day 2 (total dose=0.91Gy) and then declined whereas γ-H2AX yields generally increased with accumulated dose and peaked at day 5 (total dose=2.08Gy). ROC curve analysis for γ-H2AX provided a good discrimination of accumulated dose < 2 Gy and ≥ 2 Gy, highlighting the potential of γ-H2AX as a biomarker dosimetry in a protracted, environmental exposure scenario.

LOW-DOSE-RATE OR HIGH-DOSE-RATE BRACHYTHERAPY IN COMBINATION WITH EXTERNAL BEAM RADIOTHERAPY FOR INTERMEDIATE AND HIGH-RISK PROSTATE CANCER

2018 ◽  
Vol 64 (1) ◽  
pp. 79-83
Author(s):  
Vladimir Solodkiy ◽  
Andrey Pavlov ◽  
Aleksey Tsybulskiy ◽  
Anton Ivashin
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Dose Rate ◽  
Low Dose ◽  
External Beam Radiotherapy ◽  
Combined Treatment ◽  
High Dose ◽  
External Beam ◽  
Low Dose Rate ◽  
Risk Of Progression

Introduction. One of the main problems of modem on-courology is treatment for prostate cancer of intermediate and high risk of progression. Modern radiotherapy in this category of patients has an advantage over surgical methods of treatment. One way to improve the effectiveness of radiotherapy is to escalate the dose in the prostate gland. For this purpose a combination of brachytherapy and remote radiotherapy is used. This combination allows increasing the dose of radiation, thereby providing better local control, reducing complications from neighboring organs. Purpose of the study. To conduct a comparative analysis of efficacy and safety of radical treatment of patients with prostate cancer at medium and high risk of progression using a combination of high and low dose rate brachytherapy with external beam radiotherapy. Materials and methods. 107 patients with prostate cancer of the group of medium and high risk of progression combined treatment (brachytherapy with external beam radiotherapy) was conducted. 53 patients underwent combined treatment (HDR-brachytherapy and external beam radiotherapy). 54 patients underwent combined treatment (LDR-brachytherapy and external beam radiotherapy). The observation period was 5 years. Conclusion. In a comparative analysis in groups of combined radiotherapy with the use of high-dose and low-dose-rate brachytherapy, the same effectiveness of immediate and long-term results of treatment was demonstrated. A significant reduction in early and late toxic reactions in patients with high-power brachytherapy has been demonstrated.

Longitudinal Changes in Health-related Quality of Life After 125I Low-dose-rate Brachytherapy for Localized Prostate Cancer

2020 ◽  
Vol 40 (11) ◽  
pp. 6443-6456
Author(s):  
NAOYUKI OGASAWARA ◽  
MAKOTO NAKIRI ◽  
HIROFUMI KUROSE ◽  
KOSUKE UEDA ◽  
KATSUAKI CHIKUI ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Dose Rate ◽  
Low Dose ◽  
Health Related Quality ◽  
Low Dose Rate ◽  
Related Quality ◽  
Health Related ◽  
Low Dose Rate Brachytherapy

scholarly journals Author Correction: Observation of morphological abnormalities in silkworm pupae after feeding 137CsCl-supplemented diet to evaluate the effects of low dose-rate exposure

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sota Tanaka ◽  
Tadatoshi Kinouchi ◽  
Tsuguru Fujii ◽  
Tetsuji Imanaka ◽  
Tomoyuki Takahashi ◽  
...  
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Morphological Abnormalities ◽  
Low Dose Rate ◽  
Silkworm Pupae

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Annealing behavior of linear bipolar devices with enhanced low-dose-rate sensitivity

2004 ◽  
Vol 51 (6) ◽  
pp. 3172-3177 ◽  
Author(s):  
M.R. Shaneyfelt ◽  
J.R. Schwank ◽  
D.M. Fleetwood ◽  
R.L. Pease ◽  
J.A. Felix ◽  
...  
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Rate Sensitivity ◽  
Annealing Behavior ◽  
Low Dose Rate ◽  
Bipolar Devices

Using a Temperature-Switching Approach to Evaluate Low-Dose-Rate Ionizing Radiation Effects on SET in Linear Bipolar Circuits

2019 ◽  
Vol 66 (7) ◽  
pp. 1557-1565 ◽  
Author(s):  
Shuai Yao ◽  
Wu Lu ◽  
Xin Yu ◽  
Qi Guo ◽  
Chengfa He ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Radiation Effects ◽  
Low Dose ◽  
Low Dose Rate
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