Radiation-Induced Systemic and Local Bone Tumors: Two Types of Late Effects with Possible Different Origins?

1994 ◽  
Vol 138 (3) ◽  
pp. 415 ◽  
Author(s):  
W. A. Müller ◽  
A. Luz ◽  
U. Linzner ◽  
W. A. Muller
Keyword(s):  
Late Effects ◽  
Bone Tumors ◽  
Local Bone ◽  
Radiation Induced ◽  
Different Origins

scholarly journals Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 727 ◽  
Author(s):  
Annique C. Dombrowsky ◽  
Jannis Schauer ◽  
Matthias Sammer ◽  
Andreas Blutke ◽  
Dietrich W. M. Walsh ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Late Effects ◽  
Transforming Growth Factor ◽  
Scoring Systems ◽  
High Dose ◽  
Skin Damage ◽  
Fractional Dose ◽  
Radiation Induced ◽  
Tissue Alterations ◽  
Dose Dependent

The use of different scoring systems for radiation-induced toxicity limits comparability between studies. We examined dose-dependent tissue alterations following hypofractionated X-ray irradiation and evaluated their use as scoring criteria. Four dose fractions (0, 5, 10, 20, 30 Gy/fraction) were applied daily to ear pinnae. Acute effects (ear thickness, erythema, desquamation) were monitored for 92 days after fraction 1. Late effects (chronic inflammation, fibrosis) and the presence of transforming growth factor beta 1 (TGFβ1)-expressing cells were quantified on day 92. The maximum ear thickness displayed a significant positive correlation with fractional dose. Increased ear thickness and erythema occurred simultaneously, followed by desquamation from day 10 onwards. A significant dose-dependency was observed for the severity of erythema, but not for desquamation. After 4 × 20 and 4 × 30 Gy, inflammation was significantly increased on day 92, whereas fibrosis and the abundance of TGFβ1-expressing cells were only marginally increased after 4 × 30 Gy. Ear thickness significantly correlated with the severity of inflammation and fibrosis on day 92, but not with the number of TGFβ1-expressing cells. Fibrosis correlated significantly with inflammation and fractional dose. In conclusion, the parameter of ear thickness can be used as an objective, numerical and dose-dependent quantification criterion to characterize the severity of acute toxicity and allow for the prediction of late effects.

Late Effects in Survivors of Bone Tumors Late Effects in Survivors of Bone Tumors

1998 ◽  
Vol 15 (2) ◽  
pp. 72-84 ◽  
Author(s):  
Revonda B. Mosher ◽  
Barbara J. McCarthy
Keyword(s):  
Late Effects ◽  
Bone Tumors

scholarly journals Computer simulation of radiation-induced late effects by "system dynamics"

1986 ◽  
Vol 27 (2) ◽  
pp. 230-239 ◽  
Author(s):  
TAKASHI AOYAMA ◽  
AKIRA IMAMURA ◽  
HIDETOSHI MATSUBARA ◽  
TAKESHI IMAMURA ◽  
TSUTOMU SUGAHARA
Keyword(s):  
Computer Simulation ◽  
System Dynamics ◽  
Late Effects ◽  
Radiation Induced

scholarly journals Radiation-Induced Dual Oxidase Upregulation in Rat Heart Tissues: Protective Effect of Melatonin

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 317 ◽  
Author(s):  
Farhood ◽  
Aliasgharzadeh ◽  
Amini ◽  
Saffar ◽  
Motevaseli ◽  
...  
Keyword(s):  
Late Effects ◽  
Background Radiation ◽  
Inflammatory Cells ◽  
Chronic Oxidative Stress ◽  
Increased Risk ◽  
Male Wistar Rats ◽  
Radiation Induced ◽  
Heart Injury ◽  
Chest Irradiation ◽  
Effects Of Radiation

Background: Radiation-induced heart injury can lead to increased risk of heart failure, attack, and ischemia. Some studies proposed IL-4 and IL-13 as two important cytokines that are involved in late effects of ionizing radiation. On the other hand, these cytokines may, through upregulation of Duox1 and Duox2, induce chronic oxidative stress, inflammation, and fibrosis. In this study, we evaluated the upregulation of Duox1 and Duox2 pathways in hearts following chest irradiation in rats and then detected possible attenuation of them by melatonin. Materials and Methods: Twenty male Wistar rats were divided into four groups: (1) control; (2) melatonin treated (100 mg/kg); (3) radiation (15 Gy gamma rays); (4) melatonin treated before irradiation. All rats were sacrificed after 10 weeks and their heart tissues collected for real-time PCR (RT-PCR), ELISA detection of IL-4 and IL-13, as well as histopathological evaluation of macrophages and lymphocytes infiltration. Results: Results showed an upregulation of IL-4, IL4ra1, Duox1, and Duox2. The biggest changes were for IL4ra1 and Duox1. Treatment with melatonin before irradiation could attenuate the upregulation of all genes. Melatonin also caused a reduction in IL-4 as well as reverse infiltration of inflammatory cells. Conclusion: Duox1 and Duox2 may be involved in the late effects of radiation-induced heart injury. Also, via attenuation of these genes, melatonin can offer protection against the toxic effects of radiation on the heart.

6 Recording of radiation-induced late effects of the eye — Proposal for a new classification

2000 ◽  
Vol 57 ◽  
pp. S3-S4
Author(s):  
O. Micke ◽  
U. Schaefer ◽  
F. Bruns ◽  
K. Sell ◽  
N. Willich
Keyword(s):  
Late Effects ◽  
New Classification ◽  
Radiation Induced
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