Amplification of the c-myc Oncogene in Radiation-Induced Rat Skin Tumors as a Function of Linear Energy Transfer and Dose

1992 ◽  
Vol 131 (3) ◽  
pp. 297 ◽  
Author(s):  
Mary Felber ◽  
Fredric J. Burns ◽  
Seymour J. Garte
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Skin Tumors ◽  
Rat Skin ◽  
Myc Oncogene ◽  
Radiation Induced

scholarly journals Role of autophagy in high linear energy transfer radiation‐induced cytotoxicity to tumor cells

2014 ◽  
Vol 105 (7) ◽  
pp. 770-778 ◽  
Author(s):  
Xiaodong Jin ◽  
Yan Liu ◽  
Fei Ye ◽  
Xiongxiong Liu ◽  
Yoshiya Furusawa ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Tumor Cells ◽  
Linear Energy Transfer ◽  
Radiation Induced ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

scholarly journals Distinct Roles of Ape1 Protein, an Enzyme Involved in DNA Repair, in High or Low Linear Energy Transfer Ionizing Radiation-induced Cell Killing

2014 ◽  
Vol 289 (44) ◽  
pp. 30635-30644 ◽  
Author(s):  
Hongyan Wang ◽  
Xiang Wang ◽  
Guangnan Chen ◽  
Xiangming Zhang ◽  
Xiaobing Tang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Cell Killing ◽  
Dna Fragments ◽  
End Joining ◽  
Heavy Charged Particles ◽  
High Let Radiation ◽  
High Let ◽  
Radiation Induced ◽  
Non Homologous End Joining

High linear energy transfer (LET) radiation from space heavy charged particles or a heavier ion radiotherapy machine kills more cells than low LET radiation, mainly because high LET radiation-induced DNA damage is more difficult to repair. Relative biological effectiveness (RBE) is the ratio of the effects generated by high LET radiation to low LET radiation. Previously, our group and others demonstrated that the cell-killing RBE is involved in the interference of high LET radiation with non-homologous end joining but not homologous recombination repair. This effect is attributable, in part, to the small DNA fragments (≤40 bp) directly produced by high LET radiation, the size of which prevents Ku protein from efficiently binding to the two ends of one fragment at the same time, thereby reducing non-homologous end joining efficiency. Here we demonstrate that Ape1, an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also involved in the generation of small DNA fragments during the repair of high LET radiation-induced base damage, which contributes to the higher RBE of high LET radiation-induced cell killing. This discovery opens a new direction to develop approaches for either protecting astronauts from exposure to space radiation or benefiting cancer patients by sensitizing tumor cells to high LET radiotherapy.

Sign in / Sign up

Export Citation Format

Share Document