Neoplastic Cell Transformation by Heavy Ions

1989 ◽  
Vol 120 (3) ◽  
pp. 468 ◽  
Author(s):  
Masao Suzuki ◽  
Masami Watanabe ◽  
Keiji Suzuki ◽  
Kazushiro Nakano ◽  
Ichiro Kaneko
Keyword(s):  
Heavy Ions ◽  
Cell Transformation ◽  
Neoplastic Cell ◽  
Neoplastic Cell Transformation

scholarly journals Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2151
Author(s):  
Vera Dugina ◽  
Galina Shagieva ◽  
Mariya Novikova ◽  
Svetlana Lavrushkina ◽  
Olga Sokova ◽  
...  
Keyword(s):  
Cell Line ◽  
Chromosomal Instability ◽  
Cell Transformation ◽  
Cancer Cell Line ◽  
Neoplastic Cell ◽  
Chromosome Morphology ◽  
Human Carcinoma ◽  
Actin Isoforms ◽  
Cytoplasmic Actin ◽  
Neoplastic Cell Transformation

We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic actin acts as a tumor suppressor, whereas γ-cytoplasmic actin enhances malignant features of tumor cells. The distinct participation of each cytoplasmic actin in the cell cycle driving was also observed. The goal of this study was to describe the diverse roles of cytoplasmic actins in the progression of chromosomal instability of MDA-MB-231 basal-like human carcinoma cell line. We performed traditional methods of chromosome visualization, as well as 3D-IF microscopy and western blotting for CENP-A detection/quantification, to investigate chromosome morphology. Downregulation of cytoplasmic actin isoforms alters the phenotype and karyotype of MDA-MB-231 breast cancer cells. Moreover, β-actin depletion leads to the progression of chromosomal instability with endoreduplication and aneuploidy increase. On the contrary, γ-actin downregulation results not only in reduced percentage of mitotic carcinoma cells, but leads to chromosome stability, reduced polyploidy, and aneuploidy.

scholarly journals Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1

2007 ◽  
Vol 28 (9) ◽  
pp. 1918-1927 ◽  
Author(s):  
K. W. Lee ◽  
N. J. Kang ◽  
E. A. Rogozin ◽  
H.-G. Kim ◽  
Y. Y. Cho ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Neoplastic Cell ◽  
Neoplastic Cell Transformation ◽  
Natural Inhibitor
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