The Modification of Hemoglobin Affinity for Oxygen and Tumor Radiosensitivity by Antilipidemic Drugs

1987 ◽  
Vol 112 (1) ◽  
pp. 164 ◽  
Author(s):  
David G. Hirst ◽  
Pauline J. Wood ◽  
Herbert C. Schwartz
1971 ◽  
Vol 30 (6) ◽  
pp. 827-832 ◽  
Author(s):  
S. D. Shappell ◽  
J. A. Murray ◽  
A. J. Bellingham ◽  
R. D. Woodson ◽  
J. C. Detter ◽  
...  

1970 ◽  
Vol 26 (6) ◽  
pp. 664-665 ◽  
Author(s):  
Pantel S. Vokonas ◽  
Peter F. Cohn ◽  
Michael D. Klein ◽  
Myron B. Laver ◽  
Richard Gorlin

1990 ◽  
Vol 13 (5) ◽  
pp. 321-322 ◽  
Author(s):  
F. Soliani ◽  
T. Lusenti ◽  
V. Franco ◽  
G. Lindner ◽  
V. Davoli ◽  
...  

BIOPHYSICS ◽  
2009 ◽  
Vol 54 (3) ◽  
pp. 308-311 ◽  
Author(s):  
N. Yu. Bryzgalova ◽  
N. A. Brazhe ◽  
A. I. Yusipovich ◽  
G. V. Maksimov ◽  
A. B. Rubin

1977 ◽  
Vol 9 (1) ◽  
pp. 60
Author(s):  
J. Klein ◽  
H. V. Forster ◽  
R. D. Stewart ◽  
C. L. Hake ◽  
A. Wu ◽  
...  

1986 ◽  
Vol 463 (1 Second Colloq) ◽  
pp. 76-79
Author(s):  
ALFRED BENNUN ◽  
NORBERT SEIDLER ◽  
VINCENT A. BARI

1980 ◽  
Vol 48 (2) ◽  
pp. 236-242 ◽  
Author(s):  
J. P. Klein ◽  
H. V. Forster ◽  
R. D. Stewart ◽  
A. Wu

We assessed hemoglobin affinity for oxygen (standard P50: pH 7.40, PCO2 40 Torr, temperature 37 degrees C) in 3 series of studies of 16 male subjects who performed exhaustive treadmill exercise of 10 min duration. Standard P50 was significantly elevated (0.7--2.5 Torr) during the last minute of and for 30 min following exercise. Exercise while carboxyhemoglobin (HbCO) was acutely elevated to 5% did not affect std P50 any differently than exercise alone. 2,3-Diphosphoglycerate (2,3-DPG) was significantly elevated after exercise, but not during or 30 min postexercise, and it correlated significantly with P50 in 2 studies (r, 0.43--0.68). ATP (mumol/100 ml) was significantly elevated only 3 min postexercise. Serum [Na+], [K+], [Cl-], osmolarity, and hemoglobin (Hb) concentration were significantly elevated during exercise with [Na+] osmolarity, and [Hb] remaining significantly elevated postexercise. There was no significant correlation between std P50 and any of these variables. Multiple correlation regression analysis between P50 and 2,3-DPG, ATP, and [Na+] yields a coefficient of 0.86. We conclude this type of exercise is unique in causing a small change in std P50 that appears to be mediated by several factors.


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