Modification by cis-Diamminedichloroplatinum (II) of the Radiation Dose-Response Curve for Intestinal Crypt Cells in Mice

1987 ◽  
Vol 111 (3) ◽  
pp. 445 ◽  
Author(s):  
Luc Dewit ◽  
Yvonne Oussoren ◽  
Guus Hart
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve ◽  
Intestinal Crypt ◽  
Crypt Cells

Background Levels and Radiation Dose Yield of o-Tyrosine in Chicken Meat

1991 ◽  
Vol 54 (12) ◽  
pp. 935-938 ◽  
Author(s):  
NOEMI CHUAQUI-OFFERMANNS ◽  
TOM MCDOUGALL
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Response Curve ◽  
Dose Range ◽  
Background Level ◽  
Chicken Meat ◽  
Dose Response Curve ◽  
Poultry Meat ◽  
Wet Weight ◽  
The Mean

The measurement of o-tyrosine levels in poultry meat is a potential method for postirradiation dosimetry of poultry. The validity of using o-tyrosine for this purpose has not yet been established. As part of the validation process, the o-tyrosine content in unirradiated chicken meat, the radiation dose response curve, and the effects of postirradiation storage on o-tyrosine levels are examined. In 18 individual samples, the mean background level of o-tyrosine was 0.18 ± 0.11 ppm (wet weight, 70% moisture), and the most frequent background level (60% of the cases) was between 0.05 and 0.15 ppm (wet weight, 70% moisture). In pooled samples of 10 chickens, the mean background level was 0.12 ± 0.03 ppm (wet weight, 70% moisture). The levels were not significantly affected by storage at 5°C (7 d) or by freezing the sample. The radiation dose response curve was linear within the dose range studied (0 to 10 kGy), with a slope of 0.127 ± 0.003 ppm (wet weight)/kGy. Although there was some variation in the intercept (0.132 ± 0.013), the slope was the same in all samples tested. Postirradiation storage at either 4 or 8°C until spoilage did not affect the levels of o-tyrosine. These data indicate that o-tyrosine level may be useful for determining the absorbed dose in chicken meat gamma-irradiated to doses greater than 0.6 kGy. Further validation studies are continuing.

The Radiation Dose-Response Curve and Bacterial Mutations

Science ◽  
1951 ◽  
Vol 114 (2965) ◽  
pp. 436-437 ◽  
Author(s):  
W. E. Jordan ◽  
R. B. Mefferd ◽  
O. Wyss
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve ◽  
Bacterial Mutations

SU-FF-T-366: Radiation Dose Response Curve of Human Cerebral Cortex Measured with [F-18]-FDG and [O-15]-H2O PET Imaging

2005 ◽  
Vol 32 (6Part12) ◽  
pp. 2035-2035
Author(s):  
S Zhou ◽  
C Hahn ◽  
T Shafman ◽  
J Kirkpatrick ◽  
A Tisch ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Radiation Dose ◽  
Dose Response ◽  
Pet Imaging ◽  
Response Curve ◽  
Dose Response Curve ◽  
Human Cerebral Cortex ◽  
O 15

Cytotoxicity and influence on radiation dose response curve of cis-diamminedichloroplatinum II (cis-DDP)

1979 ◽  
Vol 5 (8) ◽  
pp. 1411-1415 ◽  
Author(s):  
Anantha K. Murthy ◽  
Arthur H. Rossof ◽  
Kenneth M. Anderson ◽  
Frank R. Hendrickson
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve

OVARIAN ASCORBIC ACID DEPLETION TEST FOR LUTEINIZING HORMONE

1967 ◽  
Vol 56 (4) ◽  
pp. 619-625 ◽  
Author(s):  
Hans Jacob Koed ◽  
Christian Hamburger
Keyword(s):  
Ascorbic Acid ◽  
Luteinizing Hormone ◽  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve ◽  
Human Origin ◽  
Response Curves ◽  
Significant Difference ◽  
The Mean ◽  
Different Levels

ABSTRACT Comparison of the dose-response curves for LH of ovine origin (NIH-LH-S8) and of human origin (IRP-HMG-2) using the OAAD test showed a small, though statistically significant difference, the dose-response curve for LH of human origin being a little flatter. Two standard curves for ovine LH obtained with 14 months' interval, were parallel but at different levels of ovarian ascorbic acid. When the mean ascorbic acid depletions were calculated as percentages of the control levels, the two curves for NIH-LH-S8 were identical. The use of standards of human origin in the OAAD test for LH activity of human preparations is recommended.

HYPERTROPHIC ADRENALS AND THEIR RESPONSE TO STRESS AFTER LESIONS IN THE MEDIAN EMINENCE OF TOTALLY HYPOPHYSECTOMIZED PIGEONS

1961 ◽  
Vol 37 (4) ◽  
pp. 565-576 ◽  
Author(s):  
Richard A. Miller
Keyword(s):  
Dose Response ◽  
Median Eminence ◽  
Response Curve ◽  
Liver Parenchyma ◽  
Dose Response Curve ◽  
Pars Distalis ◽  
Adrenal Enlargement ◽  
Response To Stress ◽  
Lethal Doses ◽  
Chromaffin Tissue

ABSTRACT Four per cent formaldehyde, insulin, or epinephrine in oil was injected for 5 days into pigeons subjected to varying degrees of hypophysectomy alone or together with large lesions in the median eminence and hypothalamus. Adrenals atrophied after the removal of the pars distalis alone or together with the neurohypophysis in untreated pigeons but showed markedly hypertrophic interrenal tissue (cortex in mammals) after treatment with formaldehyde or insulin. The slope of the dose-response curve was similar in operated and unoperated pigeons. The accumulation of bile in the liver parenchyma, which may occur after removal of the pars distalis, is an endogenous stress which was associated regularly with adrenal hypertrophy. After very large lesions of the median eminence and ventral hypothalamus in addition to total hypophysectomy, adrenals hypertrophied rather than atrophied, and the response to formaldehyde paralleled that in intact and »hypohysectomized« pigeons. Interrenal tissue was stimulated regularly; chromaffin tissue was partially degranulated, sometimes showed hyperplasia with colchicine, but only occasionally appeared hypertrophied. Epinephrine in nearly lethal doses caused only minimal adrenal enlargement. After adrenal denervation followed by hypophysectomy, the adrenals were still stimulated by formaldehyde. It appears that the interrenal tissue of the pigeon responds to a humoral stimulus not of hypophyseal origin in the absence of the hypophyseal-hypothalamic system.

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