Myeloid Leukemia in Male RFM Mice Following Irradiation with Fission Spectrum Neutrons or γ Rays

1987 ◽  
Vol 109 (1) ◽  
pp. 165 ◽  
Author(s):  
R. L. Ullrich ◽  
R. J. Preston
Keyword(s):  
Myeloid Leukemia ◽  
Fission Spectrum ◽  
Γ Rays

Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and60Co γ-rays in Mice

1992 ◽  
Vol 61 (3) ◽  
pp. 387-392 ◽  
Author(s):  
Y. Kataoka ◽  
I. Basic ◽  
J. Perrin ◽  
D.J. Grdina
Keyword(s):  
Fission Spectrum ◽  
Γ Rays

Teratogenic and embryolethal effects in mice of fission-spectrum neutrons and γ-rays

Teratology ◽  
1974 ◽  
Vol 10 (2) ◽  
pp. 133-139 ◽  
Author(s):  
A. B. Cairnie ◽  
D. Grahn ◽  
H. B. Rayburn ◽  
F. S. Williamson ◽  
R. J. Brown
Keyword(s):  
Fission Spectrum ◽  
Γ Rays

scholarly journals Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells

Blood ◽  
2012 ◽  
Vol 120 (10) ◽  
pp. 2087-2097 ◽  
Author(s):  
Kurtis J. Haro ◽  
Andrew C. Scott ◽  
David A. Scheinberg
Keyword(s):  
Dna Damage ◽  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Myeloid Leukemia ◽  
Hl60 Cell ◽  
Cross Resistance ◽  
Mechanisms Of Resistance ◽  
Acute Leukemias ◽  
Γ Rays ◽  
Α Particles

Abstract Low linear energy transfer (LET) ionizing radiation (IR) is an important form of therapy for acute leukemias administered externally or as radioimmunotherapy. IR is also a potential source of DNA damage. High LET IR produces structurally different forms of DNA damage and has emerged as potential treatment of metastatic and hematopoietic malignancies. Therefore, understanding mechanisms of resistance is valuable. We created stable myeloid leukemia HL60 cell clones radioresistant to either γ-rays or α-particles to understand possible mechanisms in radioresistance. Cross-resistance to each type of IR was observed, but resistance to clustered, complex α-particle damage was substantially lower than to equivalent doses of γ-rays. The resistant phenotype was driven by changes in: apoptosis; late G2/M checkpoint accumulation that was indicative of increased genomic instability; stronger dependence on homology-directed repair; and more robust repair of DNA double-strand breaks and sublethal-type damage induced by γ-rays, but not by α-particles. The more potent cytotoxicity of α-particles warrants their continued investigation as therapies for leukemia and other cancers.

Cardiac Injury in the Aged Mouse: Comparative Ultrastructural Effects of Fission Spectrum Neutrons and γ Rays

1979 ◽  
Vol 78 (3) ◽  
pp. 429 ◽  
Author(s):  
S. P. Stearner ◽  
V. V. Yang ◽  
R. L. Devine
Keyword(s):  
Cardiac Injury ◽  
Aged Mouse ◽  
Fission Spectrum ◽  
Γ Rays

Cross sections for the production of γ-rays as a result of inelastic scattering of neutrons of a fission spectrum

1970 ◽  
Vol 29 (5) ◽  
pp. 1080-1084
Author(s):  
A. T. Bakov ◽  
V. G. Dvukhsherstnov ◽  
Yu. A. Kazanskii
Keyword(s):  
Inelastic Scattering ◽  
Cross Sections ◽  
Fission Spectrum ◽  
Γ Rays

Neutrophil Myeloperoxidase Destruction by Ultraviolet Irradiation

1988 ◽  
Vol 46 ◽  
pp. 138-139
Author(s):  
J. Hanker ◽  
B. Giammara ◽  
G. Strauss
Keyword(s):  
Uv Radiation ◽  
Myeloid Leukemia ◽  
Stratospheric Ozone ◽  
Psoriasis Patient ◽  
Whole Body ◽  
Human Neutrophils ◽  
Cupric Nitrate ◽  
The Earth ◽  
Routine Handling ◽  
Uvb Phototherapy

Only a fraction of the UV radiation emitted by the sun reaches the earth; most of the UVB (290-320nm) is eliminated by stratospheric ozone. There is increasing concern, however, that man-made chemicals are damaging this ozone layer. Although the effects of UV on DNA or as a carcinogen are widely known, preleukemia and acute myeloid leukemia (AML) have only rarely been reported in psoriasis patients treated with 8-methoxypsoralen and UV (PUVA). It was therefore of interest to study the effects of UV on the myeloperoxidase (MP) activity of human neutrophils. The peroxidase activity of enriched leukocyte preparations on coverslips was shown cytochemically with a diaminobenzidine medium and cupric nitrate intensification.Control samples (Figs. 1,4,5) of human bloods that were not specifically exposed to UV radiation or light except during routine handling were compared with samples which had been exposed in one of several different ways. One preparation (Fig. 2) was from a psoriasis patient who had received whole-body UVB phototherapy repeatedly.

The Fine Structure of Irradiated Mouse Heart

1976 ◽  
Vol 34 ◽  
pp. 184-185
Author(s):  
Vivian V. Yang ◽  
S. Phyllis Stearner
Keyword(s):  
Microscopic Level ◽  
Ultrastructural Changes ◽  
Mouse Heart ◽  
Blood Vessel Wall ◽  
Histopathological Changes ◽  
Light Microscopic Level ◽  
Γ Rays ◽  
Fission Neutrons ◽  
Total Body

The heart is generally considered a radioresistant organ, and has received relatively little study after total-body irradiation with doses below the acutely lethal range. Some late damage in the irradiated heart has been described at the light microscopic level. However, since the dimensions of many important structures of the blood vessel wall are submicroscopic, investigators have turned to the electron microscope for adequate visualization of histopathological changes. Our studies are designed to evaluate ultrastructural changes in the mouse heart, particularly in the capillaries and muscle fibers, for 18 months after total-body exposure, and to compare the effects of 240 rad fission neutrons and 788 rad 60Co γ-rays.Three animals from each irradiated group and three control mice were sacrificed by ether inhalation at 4 days, and at 1, 3, 6, 12, and 18 months after irradiation. The thorax was opened and the heart was fixed briefly in situwith Karnofsky's fixative.

Uncommon long-term survival in a patient with chronic myeloid leukemia

2009 ◽  
pp. 1-2
Author(s):  
Fabio Stagno ◽  
Paolo Vigneri ◽  
Vittorio Del Fabro ◽  
Stefania Stella ◽  
Salvatore Berretta ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Term Survival ◽  
Long Term Survival
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