Survival of Intestinal Crypt Cells after Exposure to High Z, High-Energy Charged Particles

1980 ◽  
Vol 83 (3) ◽  
pp. 677 ◽  
Author(s):  
Edward L. Alpen ◽  
P. Powers-Risius ◽  
M. McDonald
Keyword(s):  
Charged Particles ◽  
High Energy ◽  
Intestinal Crypt ◽  
Crypt Cells

ENERGY ORDERING EFFECTS IN THE ARRIVAL DIRECTIONS OF ULTRA-HIGH ENERGY COSMIC RAYS MEASURED BY THE PIERRE AUGER OBSERVATORY

2011 ◽  
Vol 20 (supp02) ◽  
pp. 50-56
Author(s):  
◽  
PETER SCHIFFER
Keyword(s):  
Cosmic Rays ◽  
Magnetic Fields ◽  
Charged Particles ◽  
High Energy ◽  
Pierre Auger Observatory ◽  
Ultra High Energy ◽  
High Energy Cosmic Rays ◽  
Ordering Effects ◽  
Arrival Directions

The Pierre Auger Observatory is the world's largest experiment for the measurement of ultra-high energy cosmic rays (UHECRs). These UHECRs are assumed to be to be charged particles, and thus are deflected in cosmic magnetic fields. Recent results of the Pierre Auger Observatory addressing the complex of energy ordering of the UHECRs arrival directions are reviewed in this contribution. So far no significant energy ordering has been observed.

The preparation of isolated intestinal crypt cells

1969 ◽  
Vol 55 (2) ◽  
pp. 257-260 ◽  
Author(s):  
D.D. Harrison ◽  
H.L. Webster
Keyword(s):  
Intestinal Crypt ◽  
Crypt Cells

scholarly journals Glucagon-Like Peptide-2 Activates β-Catenin Signaling in the Mouse Intestinal Crypt: Role of Insulin-Like Growth Factor-I

Endocrinology ◽  
2007 ◽  
Vol 149 (1) ◽  
pp. 291-301 ◽  
Author(s):  
Philip E. Dubé ◽  
Katherine J. Rowland ◽  
Patricia L. Brubaker
Keyword(s):  
Cell Proliferation ◽  
Nuclear Translocation ◽  
Glycogen Synthase ◽  
Crypt Cell ◽  
Acute Administration ◽  
Intestinal Crypt ◽  
Crypt Cell Proliferation ◽  
Igf I ◽  
Glucagon Like Peptide ◽  
Crypt Cells

Chronic administration of glucagon-like peptide-2 (GLP-2) induces intestinal growth and crypt cell proliferation through an indirect mechanism requiring IGF-I. However, the intracellular pathways through which IGF-I mediates GLP-2-induced epithelial tropic signaling remain undefined. Because β-catenin and Akt are important regulators of crypt cell proliferation, we hypothesized that GLP-2 activates these signaling pathways through an IGF-I-dependent mechanism. In this study, fasted mice were administered Gly2-GLP-2 or LR3-IGF-I (positive control) for 0.5–4 h. Nuclear translocation of β-catenin in non-Paneth crypt cells was assessed by immunohistochemistry and expression of its downstream proliferative markers, c-myc and Sox9, by quantitative RT-PCR. Akt phosphorylation and activation of its targets, glycogen synthase kinase-3β and caspase-3, were determined by Western blot. IGF-I receptor (IGF-IR) and IGF-I signaling were blocked by preadministration of NVP-AEW541 and through the use of IGF-I knockout mice, respectively. We found that GLP-2 increased β-catenin nuclear translocation in non-Paneth crypt cells by 72 ± 17% (P < 0.05) and increased mucosal c-myc and Sox9 mRNA expression by 90 ± 20 and 376 ± 170%, respectively (P < 0.05–0.01), with similar results observed with IGF-I. This effect of GLP-2 was prevented by blocking the IGF-IR as well as ablation of IGF-I signaling. GLP-2 also produced a time- and dose-dependent activation of Akt in the intestinal mucosa (P < 0.01), most notably in the epithelium. This action was reduced by IGF-IR inhibition but not IGF-I knockout. We concluded that acute administration of GLP-2 activates β-catenin and proliferative signaling in non-Paneth murine intestinal crypt cells as well as Akt signaling in the mucosa. However, IGF-I is required only for the GLP-2-induced alterations in β-catenin.

Pseudorapidity distribution of relativistic singly charged particles in heavy-ion collisions at high energy

1999 ◽  
Vol 77 (4) ◽  
pp. 313-318 ◽  
Author(s):  
F -H Liu ◽  
Y A Panebratsev
Keyword(s):  
Experimental Data ◽  
Heavy Ion Collisions ◽  
Charged Particles ◽  
Heavy Ion ◽  
High Energy ◽  
Pseudorapidity Distribution ◽  
Ion Collisions ◽  
Singly Charged

The pseudorapidity distribution of relativistic singly charged particles produced in high-energy heavy-ion collisions is described by the thermalized cylinder picture. The calculated results are in agreement with the experimental data of lead-induced interactions at 158A GeV/c. PACS Nos.:25.75.-q and 25.75.Dw

THE HYDRODYNAMIC DESCRIPTION OF THE ENERGY AND CENTRALITY DEPENDENCES OF THE PSEUDORAPIDITY DISTRIBUTIONS OF THE PRODUCED CHARGED PARTICLES IN Au+Au COLLISIONS

2013 ◽  
Vol 22 (09) ◽  
pp. 1350069 ◽  
Author(s):  
ZHIJIN JIANG ◽  
QINGGUANG LI ◽  
GUANXIANG JIANG
Keyword(s):  
Hydrodynamic Model ◽  
Charged Particles ◽  
Heavy Ion ◽  
High Energy ◽  
Hydrodynamic Description ◽  
Gaussian Form ◽  
Ion Collisions ◽  
Phobos Collaboration ◽  
Rapidity Distributions ◽  
Pseudorapidity Distributions

By using the revised Landau hydrodynamic model and taking into account the effect of leading particles, we discuss the pseudorapidity distributions of produced charged particles in high energy heavy-ion collisions. The charged particles resulted from the freeze-out of the matter produced in collisions possess the Gaussian-like rapidity distributions. The leading particles are assumed having the rapidity distributions of the Gaussian form with the normalization constant being equal to the number of participants, which can be figured out in theory. It is found that the results from the revised Landau hydrodynamic model together with the contributions from leading particles are well consistent with the experimental data carried out by BNL-RHIC-PHOBOS Collaboration in different centrality Au + Au collisions at energies of [Formula: see text], 130 and 62.4 GeV , respectively.

High-energy gamma rays emission in coincidence with light charged particles from the32S +74Ge reaction at 210 MeV

1996 ◽  
Vol 355 (1) ◽  
pp. 35-39 ◽  
Author(s):  
F. Lucarelli ◽  
N. Gelli ◽  
P. Blasi ◽  
M. Cinausero ◽  
E. Fioretto ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Charged Particles ◽  
High Energy ◽  
High Energy Gamma ◽  
Energy Gamma ◽  
Light Charged Particles

Finding the bearings of a source of high-energy charged particles

1992 ◽  
Vol 35 (12) ◽  
pp. 1433-1436
Author(s):  
E. V. Lotyshev ◽  
V. I. Suprunov
Keyword(s):  
Charged Particles ◽  
High Energy
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