Intestinal Crypt Survival after X Irradiation of the Rat Small Intestine under Conditions of Radioprotection

1978 ◽  
Vol 74 (1) ◽  
pp. 129 ◽  
Author(s):  
Victoria L. Y. Tseng ◽  
Jerald W. Bybee ◽  
James W. Osborne
1998 ◽  
Vol 128 (11) ◽  
pp. 1869-1877 ◽  
Author(s):  
Takeshi Nikawa ◽  
Kazuhito Rokutan ◽  
Kayo Nanba ◽  
Kaori Tokuoka ◽  
Shigetada Teshima ◽  
...  

1971 ◽  
Vol 49 (1) ◽  
pp. 38-43 ◽  
Author(s):  
M. W. Liebbrman ◽  
R. J. Sullivan ◽  
K. H. Shull ◽  
H. Liang ◽  
E. Farber

We have partially characterized and localized two previously reported deoxyribonucleases from the rat small intestine. After separation of the crypt cells and muscle (the deep layer) from the villus cells (the superficial layer), the latter was found to contain a deoxyribonuclease I with a pH optimum around 6, and a molecular weight of 32 000 – 35 000. It was activated by Co2+, Mg2+, and Mn2+. Ligation of the pancreatic duct reduced the activity in intestinal extracts to about one-third of control levels. A deoxyribonuclease II with a pH optimum of 5.3–5.4 was found associated with the continuously dividing intestinal crypt cells. It was inhibited by Mg2+ and activated by EDTA. Ligation of the pancreatic duct was without effect on this enzyme. The deoxyribonuclease I is probably largely extracellular and serves a digestive function while the deoxyribonuclease II probably is related to intracellular DNA metabolism.


2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
K Nieber ◽  
S Michael ◽  
K Grötzinger ◽  
JW Rauwald ◽  
O Kelber

Diabetes ◽  
1993 ◽  
Vol 42 (8) ◽  
pp. 1126-1132 ◽  
Author(s):  
K. L. Madsen ◽  
V. M. Porter ◽  
R. N. Fedorak

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