Induction of Chromosomal Aberrations in Human Lymphocytes by X Rays and Fission Neutrons: Dependence on Cell Cycle Stage

1975 ◽  
Vol 63 (3) ◽  
pp. 403 ◽  
Author(s):  
A. V. Carrano
Keyword(s):  
Cell Cycle ◽  
Chromosomal Aberrations ◽  
Human Lymphocytes ◽  
X Rays ◽  
Cell Cycle Stage ◽  
Fission Neutrons

Chromosomal Aberrations in Human Lymphocytes Inducedin Vitroby Very Low Doses of X-rays

1992 ◽  
Vol 61 (3) ◽  
pp. 335-343 ◽  
Author(s):  
D.C. Lloyd ◽  
A.A. Edwards ◽  
A. Leonard ◽  
G.L. Deknudt ◽  
L. Verschaeve ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Human Lymphocytes ◽  
Low Doses ◽  
X Rays

Radiation-induced Chromosomal Aberrations in Mouse 10T1/2 Cells: Dependence on the Cell-cycle Stage at the Time of Irradiation

1994 ◽  
Vol 65 (4) ◽  
pp. 437-447 ◽  
Author(s):  
M. Durante ◽  
G. Gialanella ◽  
G.F. Grossi ◽  
M. Nappo ◽  
M. Pugliese ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Chromosomal Aberrations ◽  
Cell Cycle Stage ◽  
Radiation Induced

RELATION BETWEEN CELL CYCLE AND YIELD OF ABERRATIONS OBSERVED IN IRRADIATED HUMAN LYMPHOCYTES

1979 ◽  
Vol 21 (4) ◽  
pp. 473-478 ◽  
Author(s):  
A. Leonard ◽  
G. Decat
Keyword(s):  
Cell Cycle ◽  
Cell Kinetics ◽  
Human Lymphocytes ◽  
Mitotic Division ◽  
Fixation Time ◽  
X Rays ◽  
Mitotic Delay ◽  
Dividing Cells ◽  
Ionizing Radiations ◽  
Pha Stimulation

The bromodeoxyuridine-Giemsa technique has been used to study systematically the incidence of cells in first or subsequent mitoses at different fixation times of human lymphocyte control cultures as well as the influence of ionizing radiations on cell kinetics. Second divisions appear (3%) in cultures harvested 48 h after initiation. In 72 h cultures 40% of the dividing cells are in second and 33% in third division. Administration of 200 rads of X-rays before PHA stimulation results in a mitotic delay but does not increase the incidence of SCE. The yield of dicentrics after an exposure to 200 rads was the same for all cells in first mitosis regardless of fixation time. These results demonstrate that there is no evidence for the existence of sensitive subpopulations that could be distinguished by the time of the first mitotic division following stimulation.

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