The Effect of Depolymerized Deoxyribonucleic Acid and Deoxyribonucleotides on the Survival of X-Irradiated Mammalian Cells in Culture

1966 ◽  
Vol 27 (1) ◽  
pp. 41 ◽  
Author(s):  
Danilo Petrović ◽  
Branimir Miletić ◽  
Ana Ferle-Vidović ◽  
Antun Han ◽  
Danilo Petrovic ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Deoxyribonucleic Acid ◽  
Cells In Culture

Effect of pulsing electromagnetic fields on DNA synthesis in mammalian cells in culture

1986 ◽  
Vol 42 (2) ◽  
pp. 185-186 ◽  
Author(s):  
K. Takahashi ◽  
I. Kaneko ◽  
M. Date ◽  
E. Fukada
Keyword(s):  
Dna Synthesis ◽  
Electromagnetic Fields ◽  
Mammalian Cells ◽  
Cells In Culture

scholarly journals Replication of DNA containing 5-bromouracil can be mutagenic in Syrian hamster cells.

1984 ◽  
Vol 4 (11) ◽  
pp. 2449-2454 ◽  
Author(s):  
E R Kaufman
Keyword(s):  
Syrian Hamster ◽  
Mammalian Cells ◽  
Culture Medium ◽  
Cells In Culture ◽  
Thymidine Analog ◽  
High Concentrations

A new protocol for inducing mutations in mammalian cells in culture by exposure to the thymidine analog 5-bromodeoxyuridine (BrdUrd) was established. This protocol, called "DNA-dependent" mutagenesis, involved the incorporation of BrdUrd into DNA under nonmutagenic conditions and the subsequent replication of the 5-bromouracil (BrUra)-containing DNA under mutagenic conditions but with no BrdUrd present in the culture medium. The mutagenic conditions were induced by allowing BrUra-containing DNA to replicate in the presence of high concentrations of thymidine. This generated high intracellular levels of dTTP and dGTP, causing nucleotide pool imbalance. The mutagenesis induced by this protocol was found to correlate with the level of BrUra substituted for thymine in DNA.

Effects of a trinucleotide ethyl phosphotriester, Gmp(Et)Gmp(Et)U, on mammalian cells in culture

Biochemistry ◽  
1977 ◽  
Vol 16 (9) ◽  
pp. 1988-1996 ◽  
Author(s):  
Paul S. Miller ◽  
Lita T. Braiterman ◽  
Paul O. P. Ts'o
Keyword(s):  
Mammalian Cells ◽  
Cells In Culture
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