The Effect of Whole-Body X-Irradiation on the Langerhans' Islets in the Guinea Pig

1960 ◽  
Vol 13 (1) ◽  
pp. 31
Author(s):  
Nikša Allegretti ◽  
Miloje Matošić ◽  
Neda Šestan ◽  
Suzana Šlamberger ◽  
Niksa Allegretti ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Whole Body ◽  
Langerhans Islets ◽  
X Irradiation

Effect of Whole Body X-Irradiation on Plasma and Intestinal Cholinesterase and on Drug Responses of Isolated Intestinal Loops in the Rhesus Monkey, Rat and Guinea Pig

1956 ◽  
Vol 188 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Arthur B. French ◽  
Patricia E. Wall
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Rhesus Monkeys ◽  
Cholinesterase Activity ◽  
Plasma Cholinesterase ◽  
Intraluminal Pressure ◽  
Whole Body ◽  
Maximal Response ◽  
Control Loops ◽  
X Irradiation

Cholinesterase activity and responses to pressure, acetylcholine, histamine and eserine were studied in isolated intestinal loops from 15 rhesus monkeys, 4 rats and 31 guinea pigs subjected to whole body x-irradiation, and in loops from paired control animals. Ileal and jejunal nonspecific cholinesterase levels were reduced in rats 48 hours after 650 r, and in guinea pigs 48 hours after 250 r, but not in rhesus monkeys 48 hours and 7–9 days after 800 r. Monkey plasma cholinesterase levels showed only a small preterminal decrease when measured daily after 800 r. The peristaltic responses of monkey and guinea pig intestinal loops to intraluminal pressure were normal at the above intervals after radiation. In monkeys, rats and guinea pigs the dose of acetylcholine required to elicit a contraction was unchanged by radiation regardless of whether threshold dose or the dose which produced 50% of the calculated maximal response was measured. The height of the maximum contractile response of monkey ileal and jejunal loops to acetylcholine was greater at both time intervals after radiation than in control loops. This difference was not found in rats or guinea pigs or in monkeys after histamine or eserine. These observations cast doubt on the idea that changes in intestinal cholinesterase activity or in the sensitivity of intestinal muscle to acetylcholine play a significant part in the vomiting and the changes in intestinal motor activity which follow x-irradiation.

Response of the Guinea Pig to 200 Roentgens Acute Whole Body X Irradiation

Science ◽  
1950 ◽  
Vol 111 (2874) ◽  
pp. 88-90 ◽  
Author(s):  
T. J. Haley ◽  
D. H. Harris
Keyword(s):  
Guinea Pig ◽  
Whole Body ◽  
X Irradiation

Effects of Sublethal Whole-Body X-Irradiation on Glucose Tolerance in the Rat and the Guinea Pig

1960 ◽  
Vol 13 (1) ◽  
pp. 25
Author(s):  
Neda Šestan ◽  
Nikša Allegretti ◽  
Miloje Matošić ◽  
Magda Devčić ◽  
Neda Sestan ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Guinea Pig ◽  
Whole Body ◽  
X Irradiation

Response of the Guinea Pig to 200 Roentgens Acute Whole Body X Irradiation

Science ◽  
1950 ◽  
Vol 111 (2874) ◽  
pp. 88-90
Author(s):  
Thomas J. Haley ◽  
D. Harriette Harris
Keyword(s):  
Guinea Pig ◽  
Whole Body ◽  
X Irradiation

The Effect of Whole-Body X-Irradiation on the Langerhans' Islets in the Rat

1960 ◽  
Vol 13 (1) ◽  
pp. 18 ◽  
Author(s):  
Nikša Allegretti ◽  
Miloje Matošić ◽  
Neda Šestan ◽  
Magda Devčić ◽  
Luka Rabadjija ◽  
...  
Keyword(s):  
Whole Body ◽  
Langerhans Islets ◽  
X Irradiation
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