scholarly journals Endocrine Disruptors and Testis Development

1998 ◽  
Vol 106 (5) ◽  
pp. A220 ◽  
Author(s):  
Richard M. Sharpe ◽  
Katie J. Turner ◽  
John P. Sumpter
Keyword(s):  
Endocrine Disruptors ◽  
Testis Development

scholarly journals Correction to: Effects of endocrine disruptors on fetal testis development, male puberty, and transition age

Endocrine ◽  
2021 ◽  
Author(s):  
Francesco Cargnelutti ◽  
Andrea Di Nisio ◽  
Francesco Pallotti ◽  
Iva Sabovic ◽  
Matteo Spaziani ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Transition Age ◽  
Testis Development ◽  
Fetal Testis ◽  
Male Puberty

scholarly journals Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates.

2010 ◽  
Vol 47 (5) ◽  
Author(s):  
RenĂŠ Habert ◽  
Vincent Muczynski ◽  
Abdelali Lehraiki ◽  
Romain Lambrot ◽  
Charlotte LĂŠcureuil ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Endocrine Disruptors ◽  
Testis Development

scholarly journals Endocrine disruptors and testis development.

1998 ◽  
Vol 106 (5) ◽  
Author(s):  
R M Sharpe ◽  
K J Turner ◽  
J P Sumpter
Keyword(s):  
Endocrine Disruptors ◽  
Testis Development

scholarly journals Effects of endocrine disruptors on fetal testis development, male puberty, and transition age

Endocrine ◽  
2020 ◽  
Author(s):  
Francesco Cargnelutti ◽  
Andrea Di Nisio ◽  
Francesco Pallotti ◽  
Iva Sabovic ◽  
Matteo Spaziani ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Reproductive System ◽  
Current Evidence ◽  
Transition Age ◽  
Testis Development ◽  
Fetal Testis ◽  
Male Puberty ◽  
The Impact ◽  
Harmful Effects

Abstract Purpose Endocrine disruptors (EDs) are exogenous substances able to impair endocrine system; consequently, they may cause numerous adverse effects. Over the last years, particular focus has been given to their harmful effects on reproductive system, but very little is known, especially in males. The aim of this review is to discuss the detrimental effects of EDs exposure on fetal testis development, male puberty, and transition age. Methods A search for the existing literature focusing on the impact of EDs on fetal testis development, male puberty, andrological parameters (anogenital distance, penile length, and testicular volume), and testicular cancer with particular regard to pubertal age provided the most current information available for this review. Human evidence-based reports were given priority over animal and in vitro experimental results. Given the paucity of available articles on this subject, all resources were given careful consideration. Results Information about the consequences associated with EDs exposure in the current literature is limited and often conflicting, due to the scarcity of human studies and their heterogeneity. Conclusions We conclude that current evidence does not clarify the impact of EDs on human male reproductive health, although severe harmful effects had been reported in animals. Despite controversial results, overall conclusion points toward a positive association between exposure to EDs and reproductive system damage. Further long-term studies performed on wide number of subjects are necessary in order to identify damaging compounds and remove them from the environment.

Adipositas – Teil 2: Auslöser und Ursachen

2017 ◽  
Vol 15 (01) ◽  
pp. 12-18
Author(s):  
Hans-Peter Friedrichsen
Keyword(s):  
Endocrine Disruptors

SummaryAn der Entstehung von Adipositas sind zahlreiche Faktoren beteiligt. Dazu gehören auch epigenetische Veränderungen, ausgelöst durch pränatale Einflüsse wie die Ernährung der Mutter in der Schwangerschaft oder Endocrine disruptors. Neben dem Mikrobiom sowie der durch extrinsische und intrinsische Faktoren beeinflussten Regulation von Appetit und Sättigung spielt die Zusammensetzung der Ernährung eine wichtige Rolle.

Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning

2020 ◽  
Author(s):  
Azhagiya Singam Ettayapuram Ramaprasad ◽  
Phum Tachachartvanich ◽  
Denis Fourches ◽  
Anatoly Soshilov ◽  
Jennifer C.Y. Hsieh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Molecular Docking ◽  
Androgen Receptor ◽  
Endocrine Disruptors ◽  
Hormone Receptors ◽  
Steroid Hormone Receptors ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Polyfluoroalkyl Substances ◽  
Perfluoroalkyl And Polyfluoroalkyl Substances

Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) pose a substantial threat as endocrine disruptors, and thus early identification of those that may interact with steroid hormone receptors, such as the androgen receptor (AR), is critical. In this study we screened 5,206 PFASs from the CompTox database against the different binding sites on the AR using both molecular docking and machine learning techniques. We developed support vector machine models trained on Tox21 data to classify the active and inactive PFASs for AR using different chemical fingerprints as features. The maximum accuracy was 95.01% and Matthew’s correlation coefficient (MCC) was 0.76 respectively, based on MACCS fingerprints (MACCSFP). The combination of docking-based screening and machine learning models identified 29 PFASs that have strong potential for activity against the AR and should be considered priority chemicals for biological toxicity testing.

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