scholarly journals In Vivo EPR Spectroscopy of Free Radicals in the Heart

1994 ◽  
Vol 102 ◽  
pp. 45 ◽  
Author(s):  
Jay L. Zweier ◽  
Periannan Kuppusamy
Keyword(s):  
Free Radicals ◽  
Epr Spectroscopy ◽  
In Vivo Epr

scholarly journals In vivo EPR spectroscopy of free radicals in the heart.

1994 ◽  
Vol 102 (suppl 10) ◽  
pp. 45-51 ◽  
Author(s):  
J L Zweier ◽  
P Kuppusamy
Keyword(s):  
Free Radicals ◽  
Epr Spectroscopy ◽  
In Vivo Epr

In vivo EPR spectroscopy

1995 ◽  
pp. 285-299 ◽  
Author(s):  
H. M. Swartz ◽  
G. Bacic ◽  
B. Gallez ◽  
F. Goda ◽  
P. James ◽  
...  
Keyword(s):  
Epr Spectroscopy ◽  
In Vivo Epr

In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl-albumin

1998 ◽  
Vol 40 (6) ◽  
pp. 806-811 ◽  
Author(s):  
Periannan Kuppusamy ◽  
Penghai Wang ◽  
Ravi A. Shankar ◽  
Li Ma ◽  
Charles E. Trimble ◽  
...  
Keyword(s):  
Free Radicals ◽  
Epr Spectroscopy

Exercise-induced brachial artery vasodilation: role of free radicals

2007 ◽  
Vol 292 (3) ◽  
pp. H1516-H1522 ◽  
Author(s):  
Russell S. Richardson ◽  
Anthony J. Donato ◽  
Abhimanyu Uberoi ◽  
D. Walter Wray ◽  
Lesley Lawrenson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Brachial Artery ◽  
Epr Spectroscopy ◽  
Vascular Function ◽  
Paramagnetic Resonance ◽  
Healthy State ◽  
Total Antioxidant ◽  
Exercise Induced

Originally thought of as simply damaging or toxic “accidents” of in vivo chemistry, free radicals are becoming increasingly recognized as redox signaling molecules implicit in cellular homeostasis. Indeed, at the vascular level, it is plausible that oxidative stress plays a regulatory role in normal vascular function. Using electron paramagnetic resonance (EPR) spectroscopy, we sought to document the ability of an oral antioxidant cocktail (vitamins C, E, and α-lipoic acid) to reduce circulating free radicals, and we employed Doppler ultrasound to examine the consequence of an antioxidant-mediated reduction in oxidative stress on exercise-induced vasodilation. A total of 25 young (18–31 yr) healthy male subjects partook in these studies. EPR spectroscopy revealed a reduction in circulating free radicals following antioxidant administration at rest (∼98%) and as a consequence of exercise (∼85%). Plasma total antioxidant capacity and vitamin C both increased following the ingestion of the antioxidant cocktail, whereas vitamin E levels were not influenced by the ingestion of the antioxidants. Brachial artery vasodilation during submaximal forearm handgrip exercise was greater with the placebo (7.4 ± 1.8%) than with the antioxidant cocktail (2.3 ± 0.7%). These data document the efficacy of an oral antioxidant cocktail in reducing free radicals and suggest that, in a healthy state, the aggressive disruption of the delicate balance between pro- and antioxidant forces can negatively impact vascular function. These findings implicate an exercise-induced reliance upon pro-oxidant-stimulated vasodilation, thereby revealing an important and positive vascular role for free radicals.

Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ

2005 ◽  
Vol 62 (2) ◽  
pp. 293-299 ◽  
Author(s):  
Harold M. Swartz ◽  
Akinori Iwasaki ◽  
Tadeusz Walczak ◽  
Eugene Demidenko ◽  
Ildar Salikov ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Epr Spectroscopy ◽  
Non Invasive ◽  
Clinically Significant ◽  
In Vivo Epr

ChemInform Abstract: Functional in vivo EPR Spectroscopy and Imaging Using Nitroxide and Trityl Radicals

ChemInform ◽  
2012 ◽  
Vol 43 (48) ◽  
pp. no-no
Author(s):  
Valery V. Khramtsov ◽  
Jay L. Zweier
Keyword(s):  
Epr Spectroscopy ◽  
In Vivo Epr
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