scholarly journals Compensatory Regeneration, Mitogen-Induced Liver Growth, and Multistage Chemical Carcinogenesis

1993 ◽  
Vol 101 ◽  
pp. 163 ◽  
Author(s):  
Giovanna Maria Ledda-Columbano ◽  
Pierpaolo Coni ◽  
Gabriella Simbula ◽  
Ignazio Zedda ◽  
Amedeo Columbano
Keyword(s):  
Chemical Carcinogenesis ◽  
Liver Growth ◽  
Compensatory Regeneration

scholarly journals Compensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis.

1993 ◽  
Vol 101 (suppl 5) ◽  
pp. 163-168 ◽  
Author(s):  
G M Ledda-Columbano ◽  
P Coni ◽  
G Simbula ◽  
I Zedda ◽  
A Columbano
Keyword(s):  
Chemical Carcinogenesis ◽  
Liver Growth ◽  
Compensatory Regeneration

Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth

1993 ◽  
Vol 14 (9) ◽  
pp. 1825-1830 ◽  
Author(s):  
Cinzia Melchiorri ◽  
Pasquale Chieco ◽  
Antonio Ignazio Zedda ◽  
Pierpaolo Coni ◽  
Giovanna Maria Ledda-Columbano ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Liver Growth ◽  
Compensatory Regeneration

Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration

Hepatology ◽  
1993 ◽  
Vol 17 (6) ◽  
pp. 1109-1116 ◽  
Author(s):  
Pierpaolo Coni ◽  
Gabriella Simbula ◽  
Alessandra Carcereri de Prati ◽  
Marta Menegazzi ◽  
Hisanori Suzuki ◽  
...  
Keyword(s):  
Steady State ◽  
Messenger Rna ◽  
Liver Growth ◽  
Steady State Levels ◽  
Compensatory Regeneration

scholarly journals FINE STRUCTURAL ALTERATIONS IN CELL PARTICLES DURING CHEMICAL CARCINOGENESIS

1961 ◽  
Vol 10 (1) ◽  
pp. 23-36 ◽  
Author(s):  
Joseph C. Arcos ◽  
Hans H. Gosch ◽  
David Zickafoose
Keyword(s):  
Azo Dye ◽  
Chemical Carcinogenesis ◽  
Liver Mitochondria ◽  
Mitochondrial Swelling ◽  
Rat Liver Mitochondria ◽  
Significant Modification ◽  
Liver Growth ◽  
Structural Alterations ◽  
Swelling Studies ◽  
Reversible Reduction

The previous studies on the correlation between tumor incidence and changes in microsomal and mitochondrial swelling during feeding of 3'-methyl-4-dimethylaminoazobenzene to rats have been extended to other hepatic carcinogens. Administration of 4'-fluoro-4-dimethylaminoazobenzene, 4'-ethyl-2-methyl-4-dimethylaminoazobenzene, 2-acetylam-inofluorene, ethionine, and tannic acid were found to produce drastic alterations of the swelling of rat liver mitochondria. In contrast to these compounds, feeding of the non-carcinogenic azobenzene and 4-diethylaminoazobenzene produced only small changes in swelling. Significant modification in the over-all pattern of the swelling curve was observed when the usual concentration of 3'-methyl-4-dimethylaminoazobenzene was reduced, but not when the riboflavin level in the diet was increased tenfold. Feeding of high levels of this dye to the guinea pig did not affect mitochondrial swelling which is consistent with the resistance of this species to azo-dye carcinogenesis. Hypophysectomy provides protection against the alterations, produced by feeding 3'-methyl-4-dimethylaminoazobenzene, in the characteristics of thyroxine- or mercuric chloride-induced mitochondrial swelling. Studies with citric cycle substrates on mitochondrial swelling suggest block of the glutamate ⇌ α-keto-glutarate pathway after feeding 3'-methyl-4-dimethylaminoazobenzene for 4 weeks. There is a considerable, but reversible, reduction of certain types of mitochondrial swelling in two situations associated with rapid liver growth: after partial hepatectomy and after intraperitoneal injection of 20-methylcholanthrene. Naphthacene, however, which also stimulates rapid liver growth, does not affect mitochondrial swelling.

HAZARD: An Expert System for Risk Assessment of Environmental Chemicals

1987 ◽  
Vol 26 (01) ◽  
pp. 13-23 ◽  
Author(s):  
H. W. Gottinger
Keyword(s):  
Expert System ◽  
Structural Information ◽  
Chemical Carcinogenesis ◽  
Structural Features ◽  
Environmental Chemicals ◽  
Chemical Carcinogens ◽  
Carcinogenic Activity ◽  
Current State ◽  
Structure Activity ◽  
Carcinogenic Potential

AbstractThe purpose of this paper is to report on an expert system in design that screens for potential hazards from environmental chemicals on the basis of structure-activity relationships in the study of chemical carcinogenesis, particularly with respect to analyzing the current state of known structural information about chemical carcinogens and predicting the possible carcinogenicity of untested chemicals. The structure-activity tree serves as an index of known chemical structure features associated with carcinogenic activity. The basic units of the tree are the principal recognized classes of chemical carcinogens that are subdivided into subclasses known as nodes according to specific structural features that may reflect differences in carcinogenic potential among chemicals in the class. An analysis of a computerized data base of known carcinogens (knowledge base) is proposed using the structure-activity tree in order to test the validity of the tree as a classification scheme (inference engine).

Effect of Some Antioxidants on Some Liver Growth Factors

2014 ◽  
Vol 42 (3) ◽  
pp. 77-91
Author(s):  
Dwidar MF ◽  
Abdel-Megid SS ◽  
El-Naggar MIZ
Keyword(s):  
Growth Factors ◽  
Liver Growth
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